A cannabinoid receptor antagonist attenuates ghrelin-induced activation of the mesolimbic dopamine system in mice

• Published in: Physiology & behavior Vol. 184; pp. 211 - 219
• Main Authors: Kalafateli, Aimilia Lydia, Vallöf, Daniel, Jörnulf, Julia Winsa, Heilig, Markus, Jerlhag, Elisabet
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2018
• Subjects: antagonists; cannabinoid receptors; Cannabinoid receptors type 1; dopamine; Endocannabinoids; Food intake; Ghrelin; locomotion; Mesolimbic dopamine system; mice; neurons; Neurosciences; Neurovetenskaper; Mesolimbic dopamine system; Ghrelin; Food intake; Endocannabinoids; Cannabinoid receptors type 1

Ghrelin has been attributed various physiological processes including food intake and reward regulation, through activation of the mesolimbic dopamine system. Reward modulation involves the mesolimbic dopamine system, consisting of the ventral tegmental area (VTA) dopamine neurons targeting nucleus...