Early application of airway pressure release ventilation may reduce the duration of mechanical ventilation in acute respiratory distress syndrome

• Published in: Intensive care medicine Vol. 43; no. 11; pp. 1648 - 1659
• Main Authors: Zhou, Yongfang, Jin, Xiaodong, Lv, Yinxia, Wang, Peng, Yang, Yunqing, Liang, Guopeng, Wang, Bo, Kang, Yan
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.11.2017; Springer; Springer Nature B.V
• Subjects: Acute respiratory distress syndrome; Adult; Aged; Anesthesiology; Animal models; Body weight; Chronic illnesses; Comparative analysis; Continuous positive airway pressure; Continuous Positive Airway Pressure - methods; Continuous Positive Airway Pressure - utilization; Critical Care Medicine; Depression, Mental; Emergency Medicine; Female; Flow velocity; Humans; Intensive; Intensive care; Intensive Care Units - statistics & numerical data; Length of Stay; Lung - physiopathology; Lung Compliance - physiology; Lungs; Male; Mechanical ventilation; Medical research; Medicine; Medicine & Public Health; Medicine, Experimental; Mental depression; Middle Aged; Original; Oxygen - blood; Oxygenation; Pain Medicine; Patients; Pediatrics; Pneumology/Respiratory System; Pressure; Pulmonary functions; Respiratory distress syndrome; Respiratory Distress Syndrome, Adult - mortality; Respiratory Distress Syndrome, Adult - physiopathology; Respiratory Distress Syndrome, Adult - therapy; Respiratory function; Respiratory system; Respiratory therapy; Respiratory tract; Tidal Volume; Time Factors; Variance analysis; Ventilation; Ventilators; United Kingdom; Acute respiratory distress syndrome; Spontaneous breathing; Low tidal volume; Airway pressure release ventilation

Purpose Experimental animal models of acute respiratory distress syndrome (ARDS) have shown that the updated airway pressure release ventilation (APRV) methodologies may significantly improve oxygenation, maximize lung recruitment, and attenuate lung injury, without circulatory depression. This led...