Machinery, regulation and pathophysiological implications of autophagosome maturation

• Published in: Nature reviews. Molecular cell biology Vol. 22; no. 11; pp. 733 - 750
• Main Authors: Zhao, Yan G., Codogno, Patrice, Zhang, Hong
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.11.2021; Nature Publishing Group
• Subjects: 631/326/596/4130; 631/80/313; 631/80/39/2346; Autophagosomes - genetics; Autophagy; Autophagy (Cytology); Autophagy - genetics; Biochemistry; Biomedical and Life Sciences; Biosynthesis; Cancer; Cancer Research; Cell Biology; Degradation; Deregulation; Developmental Biology; Endosomes; Endosomes - genetics; Geographical distribution; Health aspects; Homeostasis; Humans; Life Sciences; Lipids; Lysosomes; Lysosomes - genetics; Maturation; Membranes; Muscles; Neurodegeneration; Neurodegenerative diseases; Neurodegenerative Diseases - genetics; Neurodegenerative Diseases - pathology; Nutrient dynamics; Nutrient status; Pathogenesis; Pathogens; Pathophysiology; Phagocytosis; Phagosomes; Phagosomes - genetics; Physiological aspects; Post-translation; Protein Processing, Post-Translational - genetics; Proteins; rab GTP-Binding Proteins - genetics; Rab protein; Regulation; Review; Review Article; SNARE Proteins - genetics; Spatial distribution; Stem Cells; Tethering; Transport Vesicles - genetics; Vacuoles; China

Autophagy is a versatile degradation system for maintaining cellular homeostasis whereby cytosolic materials are sequestered in a double-membrane autophagosome and subsequently delivered to lysosomes, where they are broken down. In multicellular organisms, newly formed autophagosomes undergo a proce...