MicroRNAs as modulators of longevity and the aging process

• Published in: Human genetics Vol. 139; no. 3; pp. 291 - 308
• Main Authors: Kinser, Holly E., Pincus, Zachary
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.03.2020; Springer; Springer Nature B.V
• Subjects: Aging; Aging - genetics; Animals; Biomarkers; Biomedical and Life Sciences; Biomedicine; Gene Function; Genetic transcription; Genetic translation; Human Genetics; Humans; Invertebrates; Longevity; Longevity - genetics; Metabolic Diseases; MicroRNA; MicroRNAs; MicroRNAs - genetics; miRNA; Molecular Genetics of Aging and Longevity; Molecular Medicine; Non-coding RNA; Post-transcription; Review; Signal Transduction - genetics

MicroRNAs (miRNAs) are short, non-coding RNAs that post-transcriptionally repress translation or induce mRNA degradation of target transcripts through sequence-specific binding. miRNAs target hundreds of transcripts to regulate diverse biological pathways and processes, including aging. Many microRN...