Gut stem cell necroptosis by genome instability triggers bowel inflammation

• Published in: Nature (London) Vol. 580; no. 7803; pp. 386 - 390
• Main Authors: Wang, Ruicong, Li, Hongda, Wu, Jianfeng, Cai, Zhi-Yu, Li, Baizhou, Ni, Hengxiao, Qiu, Xingfeng, Chen, Hui, Liu, Wei, Yang, Zhang-Hua, Liu, Min, Hu, Jin, Liang, Yaoji, Lan, Ping, Han, Jiahuai, Mo, Wei
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.04.2020; Nature Publishing Group
• Subjects: 13/1; 13/100; 13/106; 13/109; 13/21; 13/31; 13/95; 14/19; 14/28; 38/22; 38/39; 38/77; 38/91; 631/250/256/2515; 631/80/82/2344; 64/60; 82/29; 82/51; Animals; Apoptosis; Colitis; Deoxyribonucleic acid; Development and progression; DNA; DNA structure; DNA-binding protein; Endogenous retroviruses; Genetic aspects; Genome-wide association studies; Genomes; Genomic Instability; Heredity; Histone H3; Histone methyltransferase; Histone-Lysine N-Methyltransferase - genetics; Histone-Lysine N-Methyltransferase - metabolism; Histones; Homeostasis; Humanities and Social Sciences; Humans; Ileitis; Inflammation; Inflammatory bowel disease; Inflammatory bowel diseases; Inflammatory Bowel Diseases - genetics; Inflammatory Bowel Diseases - metabolism; Inflammatory Bowel Diseases - pathology; Intestine; Lysine; Methyltransferases; Mice; Mimicry; multidisciplinary; Necroptosis; Necrosis; Pathogenesis; Pathology; Physiological aspects; Proteins; RNA-Binding Proteins - genetics; RNA-Binding Proteins - metabolism; Rodents; Science; Science (multidisciplinary); Stem cell research; Stem cell transplantation; Stem cells; Stem Cells - cytology; Stem Cells - metabolism; China

The aetiology of inflammatory bowel disease (IBD) is a multifactorial interplay between heredity and environment 1 , 2 . Here we report that deficiency in SETDB1, a histone methyltransferase that mediates the trimethylation of histone H3 at lysine 9, participates in the pathogenesis of IBD. We found...