Phage combination therapies for bacterial wilt disease in tomato

Bacteriophages have been proposed as an alternative to pesticides to kill bacterial pathogens of crops. However, the efficacy of phage biocontrol is variable and poorly understood in natural rhizosphere microbiomes. We studied biocontrol efficacy of different phage combinations on Ralstonia solanace...

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Published inNature biotechnology Vol. 37; no. 12; pp. 1513 - 1520
Main Authors Wang, Xiaofang, Wei, Zhong, Yang, Keming, Wang, Jianing, Jousset, Alexandre, Xu, Yangchun, Shen, Qirong, Friman, Ville-Petri
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.12.2019
Nature Publishing Group
Subjects
631/158/1745
631/158/2456
631/158/855
631/326/2565/2134
631/61/168
Agriculture
Bacteria
Bacterial diseases of plants
Bacteriophages
Bacteriophages - genetics
Bioinformatics
Biological control
Biomedical and Life Sciences
Biomedical Engineering/Biotechnology
Biomedicine
Biotechnology
Care and treatment
Diseases and pests
Environmental aspects
Field tests
Incidence
Life Sciences
Lycopersicon esculentum - microbiology
Microbiomes
Microbiota
Pathogens
Pest Control, Biological - methods
Pesticides
Phages
Plant Diseases - microbiology
Ralstonia solanacearum - genetics
Ralstonia solanacearum - pathogenicity
Ralstonia solanacearum - virology
Rhizosphere
Tomatoes
Wilt
China
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Abstract Bacteriophages have been proposed as an alternative to pesticides to kill bacterial pathogens of crops. However, the efficacy of phage biocontrol is variable and poorly understood in natural rhizosphere microbiomes. We studied biocontrol efficacy of different phage combinations on Ralstonia solanacearum infection in tomato. Increasing the number of phages in combinations decreased the incidence of disease by up to 80% in greenhouse and field experiments during a single crop season. The decreased incidence of disease was explained by a reduction in pathogen density and the selection for phage-resistant but slow-growing pathogen strains, together with enrichment for bacterial species that were antagonistic toward R. solanacearum . Phage treatment did not affect the existing rhizosphere microbiota. Specific phage combinations have potential as precision tools to control plant pathogenic bacteria. Phage combination therapies reduce bacterial wilt disease incidence in tomato by up to 80%.
AbstractList Bacteriophages have been proposed as an alternative to pesticides to kill bacterial pathogens of crops. However, the efficacy of phage biocontrol is variable and poorly understood in natural rhizosphere microbiomes. We studied biocontrol efficacy of different phage combinations on Ralstonia solanacearum infection in tomato. Increasing the number of phages in combinations decreased the incidence of disease by up to 80% in greenhouse and field experiments during a single crop season. The decreased incidence of disease was explained by a reduction in pathogen density and the selection for phage-resistant but slow-growing pathogen strains, together with enrichment for bacterial species that were antagonistic toward R. solanacearum. Phage treatment did not affect the existing rhizosphere microbiota. Specific phage combinations have potential as precision tools to control plant pathogenic bacteria.
Bacteriophages have been proposed as an alternative to pesticides to kill bacterial pathogens of crops. However, the efficacy of phage biocontrol is variable and poorly understood in natural rhizosphere microbiomes. We studied biocontrol efficacy of different phage combinations on Ralstonia solanacearum infection in tomato. Increasing the number of phages in combinations decreased the incidence of disease by up to 80% in greenhouse and field experiments during a single crop season. The decreased incidence of disease was explained by a reduction in pathogen density and the selection for phage-resistant but slow-growing pathogen strains, together with enrichment for bacterial species that were antagonistic toward R. solanacearum. Phage treatment did not affect the existing rhizosphere microbiota. Specific phage combinations have potential as precision tools to control plant pathogenic bacteria. Phage combination therapies reduce bacterial wilt disease incidence in tomato by up to 80%.
Bacteriophages have been proposed as an alternative to pesticides to kill bacterial pathogens of crops. However, the efficacy of phage biocontrol is variable and poorly understood in natural rhizosphere microbiomes. We studied biocontrol efficacy of different phage combinations on Ralstonia solanacearum infection in tomato. Increasing the number of phages in combinations decreased the incidence of disease by up to 80% in greenhouse and field experiments during a single crop season. The decreased incidence of disease was explained by a reduction in pathogen density and the selection for phage-resistant but slow-growing pathogen strains, together with enrichment for bacterial species that were antagonistic toward R. solanacearum. Phage treatment did not affect the existing rhizosphere microbiota. Specific phage combinations have potential as precision tools to control plant pathogenic bacteria.Bacteriophages have been proposed as an alternative to pesticides to kill bacterial pathogens of crops. However, the efficacy of phage biocontrol is variable and poorly understood in natural rhizosphere microbiomes. We studied biocontrol efficacy of different phage combinations on Ralstonia solanacearum infection in tomato. Increasing the number of phages in combinations decreased the incidence of disease by up to 80% in greenhouse and field experiments during a single crop season. The decreased incidence of disease was explained by a reduction in pathogen density and the selection for phage-resistant but slow-growing pathogen strains, together with enrichment for bacterial species that were antagonistic toward R. solanacearum. Phage treatment did not affect the existing rhizosphere microbiota. Specific phage combinations have potential as precision tools to control plant pathogenic bacteria.
Bacteriophages have been proposed as an alternative to pesticides to kill bacterial pathogens of crops. However, the efficacy of phage biocontrol is variable and poorly understood in natural rhizosphere microbiomes. We studied biocontrol efficacy of different phage combinations on Ralstonia solanacearum infection in tomato. Increasing the number of phages in combinations decreased the incidence of disease by up to 80% in greenhouse and field experiments during a single crop season. The decreased incidence of disease was explained by a reduction in pathogen density and the selection for phage-resistant but slow-growing pathogen strains, together with enrichment for bacterial species that were antagonistic toward R. solanacearum . Phage treatment did not affect the existing rhizosphere microbiota. Specific phage combinations have potential as precision tools to control plant pathogenic bacteria. Phage combination therapies reduce bacterial wilt disease incidence in tomato by up to 80%.
Audience Academic
Author Shen, Qirong
Wei, Zhong
Jousset, Alexandre
Xu, Yangchun
Wang, Xiaofang
Wang, Jianing
Friman, Ville-Petri
Yang, Keming
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  surname: Wang
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  organization: Jiangsu Provincial Key Laboratory for Organic Solid Waste Utilization, Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization, National Engineering Research Center for Organic-Based Fertilizers, Nanjing Agricultural University, Weigang
– sequence: 2
  givenname: Zhong
  orcidid: 0000-0002-7967-4897
  surname: Wei
  fullname: Wei, Zhong
  email: weizhong@njau.edu.cn
  organization: Jiangsu Provincial Key Laboratory for Organic Solid Waste Utilization, Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization, National Engineering Research Center for Organic-Based Fertilizers, Nanjing Agricultural University, Weigang
– sequence: 3
  givenname: Keming
  surname: Yang
  fullname: Yang, Keming
  organization: Jiangsu Provincial Key Laboratory for Organic Solid Waste Utilization, Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization, National Engineering Research Center for Organic-Based Fertilizers, Nanjing Agricultural University, Weigang
– sequence: 4
  givenname: Jianing
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  fullname: Wang, Jianing
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  givenname: Alexandre
  surname: Jousset
  fullname: Jousset, Alexandre
  organization: Jiangsu Provincial Key Laboratory for Organic Solid Waste Utilization, Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization, National Engineering Research Center for Organic-Based Fertilizers, Nanjing Agricultural University, Weigang, Institute of Environmental Biology, Ecology and Biodiversity, Utrecht University
– sequence: 6
  givenname: Yangchun
  surname: Xu
  fullname: Xu, Yangchun
  organization: Jiangsu Provincial Key Laboratory for Organic Solid Waste Utilization, Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization, National Engineering Research Center for Organic-Based Fertilizers, Nanjing Agricultural University, Weigang
– sequence: 7
  givenname: Qirong
  orcidid: 0000-0002-4939-2506
  surname: Shen
  fullname: Shen, Qirong
  email: qirongshen@njau.edu.cn
  organization: Jiangsu Provincial Key Laboratory for Organic Solid Waste Utilization, Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization, National Engineering Research Center for Organic-Based Fertilizers, Nanjing Agricultural University, Weigang
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  givenname: Ville-Petri
  orcidid: 0000-0002-1592-157X
  surname: Friman
  fullname: Friman, Ville-Petri
  email: ville.friman@york.ac.uk
  organization: Jiangsu Provincial Key Laboratory for Organic Solid Waste Utilization, Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization, National Engineering Research Center for Organic-Based Fertilizers, Nanjing Agricultural University, Weigang, Department of Biology, University of York
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31792408$$D View this record in MEDLINE/PubMed
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Snippet Bacteriophages have been proposed as an alternative to pesticides to kill bacterial pathogens of crops. However, the efficacy of phage biocontrol is variable...
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SubjectTerms 631/158/1745
631/158/2456
631/158/855
631/326/2565/2134
631/61/168
Agriculture
Bacteria
Bacterial diseases of plants
Bacteriophages
Bacteriophages - genetics
Bioinformatics
Biological control
Biomedical and Life Sciences
Biomedical Engineering/Biotechnology
Biomedicine
Biotechnology
Care and treatment
Diseases and pests
Environmental aspects
Field tests
Incidence
Life Sciences
Lycopersicon esculentum - microbiology
Microbiomes
Microbiota
Pathogens
Pest Control, Biological - methods
Pesticides
Phages
Plant Diseases - microbiology
Ralstonia solanacearum - genetics
Ralstonia solanacearum - pathogenicity
Ralstonia solanacearum - virology
Rhizosphere
Tomatoes
Wilt
Title Phage combination therapies for bacterial wilt disease in tomato
URI https://link.springer.com/article/10.1038/s41587-019-0328-3
https://www.ncbi.nlm.nih.gov/pubmed/31792408
https://www.proquest.com/docview/2320991166
https://www.proquest.com/docview/2320872906
Volume 37
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