Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus

• Published in: Nature genetics Vol. 43; no. 3; pp. 253 - 258
• Main Authors: Adrianto, Indra, Wen, Feng, Templeton, Amanda, Wiley, Graham, King, Jarrod B, Lessard, Christopher J, Bates, Jared S, Hu, Yanqing, Kelly, Jennifer A, Kaufman, Kenneth M, Guthridge, Joel M, Alarcón-Riquelme, Marta E, Anaya, Juan-Manuel, Bae, Sang-Cheol, Bang, So-Young, Boackle, Susan A, Brown, Elizabeth E, Petri, Michelle A, Gallant, Caroline, Ramsey-Goldman, Rosalind, Reveille, John D, Vila, Luis M, Criswell, Lindsey A, Edberg, Jeffrey C, Freedman, Barry I, Gregersen, Peter K, Gilkeson, Gary S, Jacob, Chaim O, James, Judith A, Kamen, Diane L, Kimberly, Robert P, Martin, Javier, Merrill, Joan T, Niewold, Timothy B, Park, So-Yeon, Pons-Estel, Bernardo A, Scofield, R Hal, Stevens, Anne M, Tsao, Betty P, Vyse, Timothy J, Langefeld, Carl D, Harley, John B, Moser, Kathy L, Webb, Carol F, Humphrey, Mary Beth, Montgomery, Courtney Gray, Gaffney, Patrick M
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.03.2011; Nature Publishing Group
• Subjects: 631/208/205; 631/208/2489/144; 692/699/249/1313/1613; Agriculture; Alliances; Animal Genetics and Genomics; Arthritis; Autoimmune diseases; Base Sequence; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Cancer Research; Chromosomes; Disease susceptibility; DNA-Binding Proteins; Female; Fundamental and applied biological sciences. Psychology; Gene Function; Genetic aspects; Genetics; Genetics of eukaryotes. Biological and molecular evolution; Haplotypes; Health aspects; Health sciences; Human Genetics; Humans; Intracellular Signaling Peptides and Proteins - genetics; letter; Linkage Disequilibrium; Lupus; Lupus Erythematosus, Systemic - genetics; Male; Medical sciences; MEDICIN; MEDICINE; Molecular Sequence Data; Nuclear Proteins - genetics; Polymorphism, Single Nucleotide; Quality control; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Science; Systemic lupus erythematosus; Tumor necrosis factor; Tumor Necrosis Factor alpha-Induced Protein 3; United Kingdom; Variant; Immunopathology; Connective tissue disease; Skin disease; Association; Systemic lupus erythematosus; Systemic disease; Autoimmune disease

Patrick Gaffney and colleagues perform a fine-mapping study of the TNFAIP3 region in systemic lupus erythematosus using individuals from diverse ancestral populations. They identify a putative causal variant in a region of high conservation and regulatory potential that is associated with reduced TN...