Distinct histone modifications define initiation and repair of meiotic recombination in the mouse

• Published in: The EMBO journal Vol. 28; no. 17; pp. 2616 - 2624
• Main Authors: Buard, Jérôme, Barthès, Pauline, Grey, Corinne, de Massy, Bernard
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 02.09.2009; Nature Publishing Group UK; Springer Nature B.V; EMBO Press; Nature Publishing Group
• Subjects: Animals; Cell division; chromatin; Crossing Over, Genetic; crossover; Deoxyribonucleic acid; DNA; DNA Breaks, Double-Stranded; DNA Repair; EMBO09; EMBO13; Genetic recombination; Genetics; Genomics; histone; Histones - metabolism; hotspot; Life Sciences; meiosis; Meiosis - genetics; Mice; Mice, Inbred Strains; Molecular biology; Recombination, Genetic; Rodents; crossover; meiosis; histone; chromatin; hotspot

Little is known about the factors determining the location and activity of the rapidly evolving meiotic crossover hotspots that shape genome diversity. Here, we show that several histone modifications are enriched at the active mouse Psmb9 hotspot, and we distinguish those marks that precede from th...