Sequential assembly of cell-laden hydrogel constructs to engineer vascular-like microchannels
Microscale technologies, such as microfluidic systems, provide powerful tools for building biomimetic vascular‐like structures for tissue engineering or in vitro tissue models. Recently, modular approaches have emerged as attractive approaches in tissue engineering to achieve precisely controlled ar...
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| Published in | Biotechnology and bioengineering Vol. 108; no. 7; pp. 1693 - 1703 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Hoboken
Wiley Subscription Services, Inc., A Wiley Company
01.07.2011
Wiley Wiley Subscription Services, Inc |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Microscale technologies, such as microfluidic systems, provide powerful tools for building biomimetic vascular‐like structures for tissue engineering or in vitro tissue models. Recently, modular approaches have emerged as attractive approaches in tissue engineering to achieve precisely controlled architectures by using microengineered components. Here, we sequentially assembled microengineered hydrogels (microgels) into hydrogel constructs with an embedded network of microchannels. Arrays of microgels with predefined internal microchannels were fabricated by photolithography and assembled into 3D tubular construct with multi‐level interconnected lumens. In the current setting, the sequential assembly of microgels occurred in a biphasic reactor and was initiated by swiping a needle to generate physical forces and fluidic shear. We optimized the conditions for assembly and successfully perfused fluids through the interconnected constructs. The sequential assembly process does not significantly influence cell viability within the microgels indicating its promise as a biofabrication method. Finally, in an attempt to build a biomimetic 3D vasculature, we incorporated endothelial cells and smooth muscle cells into an assembled construct with a concentric microgel design. The sequential assembly is simple, rapid, cost‐effective, and could be used for fabricating tissue constructs with biomimetic vasculature and other complex architectures. Biotechnol. Bioeng. 2011; 108:1693–1703. © 2011 Wiley Periodicals, Inc. |
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| AbstractList | Microscale technologies, such as microfluidic systems, provide powerful tools for building biomimetic vascular-like structures for tissue engineering or in vitro tissue models. Recently, modular approaches have emerged as attractive approaches in tissue engineering to achieve precisely controlled architectures by using microengineered components. Here, we sequentially assembled microengineered hydrogels (microgels) into hydrogel constructs with an embedded network of microchannels. Arrays of microgels with predefined internal microchannels were fabricated by photolithography and assembled into 3D tubular construct with multi-level interconnected lumens. In the current setting, the sequential assembly of microgels occurred in a biphasic reactor and was initiated by swiping a needle to generate physical forces and fluidic shear. We optimized the conditions for assembly and successfully perfused fluids through the interconnected constructs. The sequential assembly process does not significantly influence cell viability within the microgels indicating its promise as a biofabrication method. Finally, in an attempt to build a biomimetic 3D vasculature, we incorporated endothelial cells and smooth muscle cells into an assembled construct with a concentric microgel design. The sequential assembly is simple, rapid, cost-effective, and could be used for fabricating tissue constructs with biomimetic vasculature and other complex architectures. [PUBLICATION ABSTRACT] Microscale technologies, such as microfluidic systems, provide powerful tools for building biomimetic vascular-like structures for tissue engineering or in vitro tissue models. Recently, modular approaches have emerged as attractive approaches in tissue engineering to achieve precisely controlled architectures by using microengineered components. Here, we sequentially assembled microengineered hydrogels (microgels) into hydrogel constructs with an embedded network of microchannels. Arrays of microgels with predefined internal microchannels were fabricated by photolithography and assembled into 3D tubular construct with multi-level interconnected lumens. In the current setting, the sequential assembly of microgels occurred in a biphasic reactor and was initiated by swiping a needle to generate physical forces and fluidic shear. We optimized the conditions for assembly and successfully perfused fluids through the interconnected constructs. The sequential assembly process does not significantly influence cell viability within the microgels indicating its promise as a biofabrication method. Finally, in an attempt to build a biomimetic 3D vasculature, we incorporated endothelial cells and smooth muscle cells into an assembled construct with a concentric microgel design. The sequential assembly is simple, rapid, cost-effective, and could be used for fabricating tissue constructs with biomimetic vasculature and other complex architectures. Biotechnol. Bioeng. 2011; 108:1693-1703. ? 2011 Wiley Periodicals, Inc. Microscale technologies, such as microfluidic systems, provide powerful tools for building biomimetic vascular-like structures for tissue engineering or in vitro tissue models. Recently, modular approaches have emerged as attractive approaches in tissue engineering to achieve precisely controlled architectures by using microengineered components. Here, we sequentially assembled microengineered hydrogels (microgels) into hydrogel constructs with an embedded network of microchannels. Arrays of microgels with predefined internal microchannels were fabricated by photolithography and assembled into 3D tubular construct with multi-level interconnected lumens. In the current setting, the sequential assembly of microgels occurred in a biphasic reactor and was initiated by swiping a needle to generate physical forces and fluidic shear. We optimized the conditions for assembly and successfully perfused fluids through the interconnected constructs. The sequential assembly process does not significantly influence cell viability within the microgels indicating its promise as a biofabrication method. Finally, in an attempt to build a biomimetic 3D vasculature, we incorporated endothelial cells and smooth muscle cells into an assembled construct with a concentric microgel design. The sequential assembly is simple, rapid, cost-effective, and could be used for fabricating tissue constructs with biomimetic vasculature and other complex architectures. Microscale technologies, such as microfluidic systems, provide powerful tools for building biomimetic vascular-like structures for tissue engineering or in vitro tissue models. Recently, modular approaches have emerged as attractive approaches in tissue engineering to achieve precisely controlled architectures by using microengineered components. Here, we sequentially assembled microengineered hydrogels (microgels) into hydrogel constructs with an embedded network of microchannels. Arrays of microgels with predefined internal microchannels were fabricated by photolithography and assembled into 3D tubular construct with multi-level interconnected lumens. In the current setting, the sequential assembly of microgels occurred in a biphasic reactor and was initiated by swiping a needle to generate physical forces and fluidic shear. We optimized the conditions for assembly and successfully perfused fluids through the interconnected constructs. The sequential assembly process does not significantly influence cell viability within the microgels indicating its promise as a biofabrication method. Finally, in an attempt to build a biomimetic 3D vasculature, we incorporated endothelial cells and smooth muscle cells into an assembled construct with a concentric microgel design. The sequential assembly is simple, rapid, cost-effective and could be used for fabricating tissue constructs with biomimetic vasculature and other complex architectures. Microscale technologies, such as microfluidic systems, provide powerful tools for building biomimetic vascular‐like structures for tissue engineering or in vitro tissue models. Recently, modular approaches have emerged as attractive approaches in tissue engineering to achieve precisely controlled architectures by using microengineered components. Here, we sequentially assembled microengineered hydrogels (microgels) into hydrogel constructs with an embedded network of microchannels. Arrays of microgels with predefined internal microchannels were fabricated by photolithography and assembled into 3D tubular construct with multi‐level interconnected lumens. In the current setting, the sequential assembly of microgels occurred in a biphasic reactor and was initiated by swiping a needle to generate physical forces and fluidic shear. We optimized the conditions for assembly and successfully perfused fluids through the interconnected constructs. The sequential assembly process does not significantly influence cell viability within the microgels indicating its promise as a biofabrication method. Finally, in an attempt to build a biomimetic 3D vasculature, we incorporated endothelial cells and smooth muscle cells into an assembled construct with a concentric microgel design. The sequential assembly is simple, rapid, cost‐effective, and could be used for fabricating tissue constructs with biomimetic vasculature and other complex architectures. Biotechnol. Bioeng. 2011; 108:1693–1703. © 2011 Wiley Periodicals, Inc. Microscale technologies, such as microfluidic systems, provide powerful tools for building biomimetic vascular-like structures for tissue engineering or in vitro tissue models. Recently, modular approaches have emerged as attractive approaches in tissue engineering to achieve precisely controlled architectures by using microengineered components. Here, we sequentially assembled microengineered hydrogels (microgels) into hydrogel constructs with an embedded network of microchannels. Arrays of microgels with predefined internal microchannels were fabricated by photolithography and assembled into 3D tubular construct with multi-level interconnected lumens. In the current setting, the sequential assembly of microgels occurred in a biphasic reactor and was initiated by swiping a needle to generate physical forces and fluidic shear. We optimized the conditions for assembly and successfully perfused fluids through the interconnected constructs. The sequential assembly process does not significantly influence cell viability within the microgels indicating its promise as a biofabrication method. Finally, in an attempt to build a biomimetic 3D vasculature, we incorporated endothelial cells and smooth muscle cells into an assembled construct with a concentric microgel design. The sequential assembly is simple, rapid, cost-effective, and could be used for fabricating tissue constructs with biomimetic vasculature and other complex architectures.Microscale technologies, such as microfluidic systems, provide powerful tools for building biomimetic vascular-like structures for tissue engineering or in vitro tissue models. Recently, modular approaches have emerged as attractive approaches in tissue engineering to achieve precisely controlled architectures by using microengineered components. Here, we sequentially assembled microengineered hydrogels (microgels) into hydrogel constructs with an embedded network of microchannels. Arrays of microgels with predefined internal microchannels were fabricated by photolithography and assembled into 3D tubular construct with multi-level interconnected lumens. In the current setting, the sequential assembly of microgels occurred in a biphasic reactor and was initiated by swiping a needle to generate physical forces and fluidic shear. We optimized the conditions for assembly and successfully perfused fluids through the interconnected constructs. The sequential assembly process does not significantly influence cell viability within the microgels indicating its promise as a biofabrication method. Finally, in an attempt to build a biomimetic 3D vasculature, we incorporated endothelial cells and smooth muscle cells into an assembled construct with a concentric microgel design. The sequential assembly is simple, rapid, cost-effective, and could be used for fabricating tissue constructs with biomimetic vasculature and other complex architectures. |
| Author | Xiao, Wenqian Qi, Hao Haas, Nikhil Du, Yanan Khademhosseini, Ali Ghodousi, Majid |
| AuthorAffiliation | 4 Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, MA 02215, USA 2 Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA 1 Center for Biomedical Engineering, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA 02139, USA 5 Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, 100084, China 3 Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts 02215, USA |
| AuthorAffiliation_xml | – name: 3 Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts 02215, USA – name: 2 Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA – name: 5 Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, 100084, China – name: 1 Center for Biomedical Engineering, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA 02139, USA – name: 4 Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, MA 02215, USA |
| Author_xml | – sequence: 1 givenname: Yanan surname: Du fullname: Du, Yanan organization: Department of Medicine, Center for Biomedical Engineering, Brigham and Women's Hospital, Harvard Medical School, Cambridge, Massachusetts 02139; telephone: -768-8395; fax: -768-8477 – sequence: 2 givenname: Majid surname: Ghodousi fullname: Ghodousi, Majid organization: Department of Medicine, Center for Biomedical Engineering, Brigham and Women's Hospital, Harvard Medical School, Cambridge, Massachusetts 02139; telephone: -768-8395; fax: -768-8477 – sequence: 3 givenname: Hao surname: Qi fullname: Qi, Hao organization: Department of Medicine, Center for Biomedical Engineering, Brigham and Women's Hospital, Harvard Medical School, Cambridge, Massachusetts 02139; telephone: -768-8395; fax: -768-8477 – sequence: 4 givenname: Nikhil surname: Haas fullname: Haas, Nikhil organization: Department of Medicine, Center for Biomedical Engineering, Brigham and Women's Hospital, Harvard Medical School, Cambridge, Massachusetts 02139; telephone: -768-8395; fax: -768-8477 – sequence: 5 givenname: Wenqian surname: Xiao fullname: Xiao, Wenqian organization: Department of Medicine, Center for Biomedical Engineering, Brigham and Women's Hospital, Harvard Medical School, Cambridge, Massachusetts 02139; telephone: -768-8395; fax: -768-8477 – sequence: 6 givenname: Ali surname: Khademhosseini fullname: Khademhosseini, Ali email: alik@rics.bwh.harvard.edu organization: Department of Medicine, Center for Biomedical Engineering, Brigham and Women's Hospital, Harvard Medical School, Cambridge, Massachusetts 02139; telephone: -768-8395; fax: -768-8477 |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24238768$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/21337336$$D View this record in MEDLINE/PubMed |
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| Copyright | Copyright © 2011 Wiley Periodicals, Inc. 2015 INIST-CNRS Copyright John Wiley and Sons, Limited Jul 2011 |
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| Issue | 7 |
| Keywords | Reconstruction microengineered hydrogel Biomimetics Tissue engineering Blood vessel Network biomimetic biofabrication Hydrogel directed assembly vascular constructs Biomedical engineering |
| Language | English |
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| Notes | US Army Corps of Engineers Wyss Institute for Biologically Inspired Engineering ArticleID:BIT23102 Yanan Du and Majid Ghodousi contributed equally to this work. istex:B2057CF405660645FB71565DF3A5CDAC93D091EA ark:/67375/WNG-0MKTJKS9-R National Institute of Health - No. HL092836; No. DE019024; No. HL099073 National Science Foundation - No. DMR0847287 Office of Naval Research SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 14 ObjectType-Article-1 ObjectType-Feature-2 content type line 23 These authors contributed equally to this work. |
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| References | Lovett M, Lee K, Edwards A, Kaplan DL. 2009. Vascularization strategies for tissue engineering. Tissue Eng Part B Rev 15(3): 353-370. McGuigan AP, Sefton MV. 2006. Vascularized organoid engineered by modular assembly enables blood perfusion. Proc Natl Acad Sci USA 103(31): 11461-11466. Borenstein JT, Tupper MM, Mack PJ, Weinberg EJ, Khalil AS, Hsiao J, Garcia-Cardena G. 2010. Functional endothelialized microvascular networks with circular cross-sections in a tissue culture substrate. Biomed Microdevices 12(1): 71-79. Khademhosseini A, Vacanti J, Langer R. 2009. Progress in tissue engieering. Sci Am 300(5): 64-71. Shi Z, Chen N, Du Y, Khademhosseini A, Alber M. 2009. Stochastic model of self-assembly of cell-laden hydrogels. Phys Rev E Stat Nonlin Soft Matter Phys 80(6 Pt 1): 061901. Stegemann JP, Kaszuba SN, Rowe SL. 2007. Review: Advances in vascular tissue engineering using protein-based biomaterials. Tissue Eng 13(11): 2601-2613. 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Expert Opin Biol Ther 10(3): 409-420. Nichol JW, Khademhosseini A. 2009. Modular tissue engineering: Engineering biological tissues from the bottom up. Soft Matter 5(7): 1312-1319. Jones PA. 1979. Construction of an artificial blood vessel wall from cultured endothelial and smooth muscle cells. Proc Natl Acad Sci USA 76(4): 1882-1886. Gombotz WR, Wang GH, Horbett TA, Hoffman AS. 1991. Protein adsorption to poly(ethylene oxide) surfaces. J Biomed Mater Res 25(12): 1547-1562. Ling Y, Rubin J, Deng Y, Huang C, Demirci U, Karp JM, Khademhosseini A. 2007. A cell-laden microfluidic hydrogel. Lab Chip 7(6): 756-762. Hacking SA, Khademhosseini A. 2009. Applications of microscale technologies for regenerative dentistry. J Dent Res 88(5): 409-421. Khademhosseini A, Langer R, Borenstein J, Vacanti JP. 2006. Microscale technologies for tissue engineering and biology. Proc Natl Acad Sci USA 103(8): 2480-2487. Fiddes LK, Raz N, Srigunapalan S, Tumarkan E, Simmons CA, Wheeler AR, Kumacheva E. 2010. 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Photopolymerizable hydrogels for tissue engineering applications. Biomaterials 23(22): 4307-4314. Jen-Huang H, Jeongyun K, Nitin A, Arjun PS, Joseph EM, Arul J, Victor MU. 2009. Rapid fabrication of bio-inspired 3D microfluidic vascular networks. Adv Mater 21(35): 3567-3571. Andersson H, van den Berg A. 2004. Microfabrication and microfluidics for tissue engineering: State of the art and future opportunities. Lab Chip 4(2): 98-103. Menolascina F, Bellomo D, Maiwald T, Bevilacqua V, Ciminelli C, Paradiso A, Tommasi S. 2009. Developing optimal input design strategies in cancer systems biology with applications to microfluidic device engineering. BMC Bioinformatics 10(Suppl 12): S4. Golden AP, Tien J. 2007. Fabrication of microfluidic hydrogels using molded gelatin as a sacrificial element. Lab Chip 7(6): 720-725. Choi NW, Cabodi M, Held B, Gleghorn JP, Bonassar LJ, Stroock AD. 2007. Microfluidic scaffolds for tissue engineering. Nat Mater 6(11): 908-915. 2010; 12 2006; 71 2009; 88 2010; 10 2010; 31 2009; 21 2009; 80 2004; 4 2004; 6 2008; 105 2006; 2 1979; 76 2007; 13 2000; 407 2009; 2009 2009; 30 1991; 25 2009; 10 2002; 23 2007; 6 2007; 7 2009; 300 2009; 5 2003; 100 2006; 442 2009; 15 2006; 103 e_1_2_7_6_1 e_1_2_7_5_1 e_1_2_7_4_1 e_1_2_7_3_1 e_1_2_7_9_1 e_1_2_7_8_1 e_1_2_7_7_1 e_1_2_7_19_1 e_1_2_7_18_1 e_1_2_7_17_1 e_1_2_7_16_1 e_1_2_7_2_1 e_1_2_7_15_1 e_1_2_7_14_1 e_1_2_7_13_1 e_1_2_7_12_1 e_1_2_7_11_1 e_1_2_7_10_1 e_1_2_7_26_1 e_1_2_7_27_1 e_1_2_7_28_1 e_1_2_7_29_1 e_1_2_7_30_1 e_1_2_7_25_1 e_1_2_7_31_1 e_1_2_7_24_1 e_1_2_7_23_1 e_1_2_7_22_1 e_1_2_7_21_1 e_1_2_7_20_1 40251811 - Biotechnol Bioeng. 2025 Apr 18. doi: 10.1002/bit.29007. 40325613 - Biotechnol Bioeng. 2025 May 5. doi: 10.1002/bit.28953. |
| References_xml | – reference: Jen-Huang H, Jeongyun K, Nitin A, Arjun PS, Joseph EM, Arul J, Victor MU. 2009. Rapid fabrication of bio-inspired 3D microfluidic vascular networks. Adv Mater 21(35): 3567-3571. – reference: Golden AP, Tien J. 2007. Fabrication of microfluidic hydrogels using molded gelatin as a sacrificial element. Lab Chip 7(6): 720-725. – reference: Khademhosseini A, Langer R, Borenstein J, Vacanti JP. 2006. Microscale technologies for tissue engineering and biology. Proc Natl Acad Sci USA 103(8): 2480-2487. – reference: Choi NW, Cabodi M, Held B, Gleghorn JP, Bonassar LJ, Stroock AD. 2007. Microfluidic scaffolds for tissue engineering. Nat Mater 6(11): 908-915. – reference: Carmeliet P, Jain RK. 2000. Angiogenesis in cancer and other diseases. Nature 407(6801): 249-257. – reference: Shi Z, Chen N, Du Y, Khademhosseini A, Alber M. 2009. Stochastic model of self-assembly of cell-laden hydrogels. Phys Rev E Stat Nonlin Soft Matter Phys 80(6 Pt 1): 061901. – reference: Nichol JW, Koshy ST, Bae H, Hwang CM, Yamanlar S, Khademhosseini A. 2010. Cell-laden microengineered gelatin methacrylate hydrogels. Biomaterials 31(21): 5536-5544. – reference: Visconti RP, Kasyanov V, Gentile C, Zhang J, Markwald RR, Mironov V. 2010. Towards organ printing: Engineering an intra-organ branched vascular tree. Expert Opin Biol Ther 10(3): 409-420. – reference: Whitesides GM. 2006. The origins and the future of microfluidics. Nature 442(7101): 368-373. – reference: Hacking SA, Khademhosseini A. 2009. Applications of microscale technologies for regenerative dentistry. J Dent Res 88(5): 409-421. – reference: van der Meer AD, Poot AA, Duits MH, Feijen J, Vermes I. 2009. Microfluidic technology in vascular research. J Biomed Biotechnol 2009: 823148. – reference: McGuigan AP, Sefton MV. 2006. Vascularized organoid engineered by modular assembly enables blood perfusion. Proc Natl Acad Sci USA 103(31): 11461-11466. – reference: Andersson H, van den Berg A. 2004. Microfabrication and microfluidics for tissue engineering: State of the art and future opportunities. Lab Chip 4(2): 98-103. – reference: Lutolf MP, Lauer-Fields JL, Schmoekel HG, Metters AT, Weber FE, Fields GB, Hubbell JA. 2003. Synthetic matrix metalloproteinase-sensitive hydrogels for the conduction of tissue regeneration: Engineering cell-invasion characteristics. Proc Natl Acad Sci USA 100(9): 5413-5418. – reference: Shin M, Matsuda K, Ishii O, Terai H, Kaazempur-Mofrad M, Borenstein J, Detmar M, Vacanti JP. 2004. Endothelialized networks with a vascular geometry in microfabricated poly(dimethyl siloxane). Biomed Microdevices 6(4): 269-278. – reference: Chrobak KM, Potter DR, Tien J. 2006. Formation of perfused, functional microvascular tubes in vitro. Microvasc Res 71(3): 185-196. – reference: Fiddes LK, Raz N, Srigunapalan S, Tumarkan E, Simmons CA, Wheeler AR, Kumacheva E. 2010. A circular cross-section PDMS microfluidics system for replication of cardiovascular flow conditions. Biomaterials 31(13): 3459-3464. – reference: Du Y, Lo E, Ali S, Khademhosseini A. 2008. Directed assembly of cell-laden microgels for fabrication of 3D tissue constructs. Proc Natl Acad Sci USA 105(28): 9522-9527. – reference: Mironov V, Visconti RP, Kasyanov V, Forgacs G, Drake CJ, Markwald RR. 2009. Organ printing: Tissue spheroids as building blocks. Biomaterials 30(12): 2164-2174. – reference: Stegemann JP, Kaszuba SN, Rowe SL. 2007. Review: Advances in vascular tissue engineering using protein-based biomaterials. Tissue Eng 13(11): 2601-2613. – reference: Nichol JW, Khademhosseini A. 2009. Modular tissue engineering: Engineering biological tissues from the bottom up. Soft Matter 5(7): 1312-1319. – reference: Gombotz WR, Wang GH, Horbett TA, Hoffman AS. 1991. Protein adsorption to poly(ethylene oxide) surfaces. J Biomed Mater Res 25(12): 1547-1562. – reference: Jones PA. 1979. Construction of an artificial blood vessel wall from cultured endothelial and smooth muscle cells. Proc Natl Acad Sci USA 76(4): 1882-1886. – reference: Borenstein JT, Tupper MM, Mack PJ, Weinberg EJ, Khalil AS, Hsiao J, Garcia-Cardena G. 2010. Functional endothelialized microvascular networks with circular cross-sections in a tissue culture substrate. Biomed Microdevices 12(1): 71-79. – reference: Lovett M, Lee K, Edwards A, Kaplan DL. 2009. Vascularization strategies for tissue engineering. Tissue Eng Part B Rev 15(3): 353-370. – reference: Menolascina F, Bellomo D, Maiwald T, Bevilacqua V, Ciminelli C, Paradiso A, Tommasi S. 2009. Developing optimal input design strategies in cancer systems biology with applications to microfluidic device engineering. BMC Bioinformatics 10(Suppl 12): S4. – reference: Ling Y, Rubin J, Deng Y, Huang C, Demirci U, Karp JM, Khademhosseini A. 2007. A cell-laden microfluidic hydrogel. 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Dent Res – volume: 31 start-page: 3459 issue: 13 year: 2010 end-page: 3464 article-title: A circular cross‐section PDMS microfluidics system for replication of cardiovascular flow conditions publication-title: Biomaterials – volume: 7 start-page: 720 issue: 6 year: 2007 end-page: 725 article-title: Fabrication of microfluidic hydrogels using molded gelatin as a sacrificial element publication-title: Lab Chip – volume: 15 start-page: 353 issue: 3 year: 2009 end-page: 370 article-title: Vascularization strategies for tissue engineering publication-title: Tissue Eng Part B Rev – volume: 25 start-page: 1547 issue: 12 year: 1991 end-page: 1562 article-title: Protein adsorption to poly(ethylene oxide) surfaces publication-title: J Biomed Mater Res – volume: 21 start-page: 3567 issue: 35 year: 2009 end-page: 3571 article-title: Rapid fabrication of bio‐inspired 3D microfluidic vascular networks publication-title: Adv Mater – volume: 30 start-page: 2164 issue: 12 year: 2009 end-page: 2174 article-title: Organ printing: Tissue spheroids as building blocks publication-title: Biomaterials – volume: 23 start-page: 4307 issue: 22 year: 2002 end-page: 4314 article-title: Photopolymerizable hydrogels for tissue engineering applications publication-title: Biomaterials – volume: 407 start-page: 249 issue: 6801 year: 2000 end-page: 257 article-title: Angiogenesis in cancer and other diseases publication-title: Nature – volume: 80 start-page: 061901 issue: 6 Pt 1 year: 2009 article-title: Stochastic model of self‐assembly of cell‐laden hydrogels publication-title: Phys Rev E Stat Nonlin Soft Matter Phys – volume: 10 start-page: 409 issue: 3 year: 2010 end-page: 420 article-title: Towards organ printing: Engineering an intra‐organ branched vascular tree publication-title: Expert Opin Biol Ther – volume: 71 start-page: 185 issue: 3 year: 2006 end-page: 196 article-title: Formation of perfused, functional microvascular tubes in vitro publication-title: Microvasc Res – volume: 13 start-page: 2601 issue: 11 year: 2007 end-page: 2613 article-title: Review: Advances in vascular tissue engineering using protein‐based biomaterials publication-title: Tissue Eng – volume: 442 start-page: 368 issue: 7101 year: 2006 end-page: 373 article-title: The origins and the future of microfluidics publication-title: Nature – volume: 2 start-page: 1 issue: 1 year: 2006 end-page: 8 article-title: PEG‐based hydrogels as an in vitro encapsulation platform for testing controlled beta‐cell microenvironments publication-title: Acta Biomater – volume: 5 start-page: 1312 issue: 7 year: 2009 end-page: 1319 article-title: Modular tissue engineering: Engineering biological tissues from the bottom up publication-title: Soft Matter – volume: 12 start-page: 71 issue: 1 year: 2010 end-page: 79 article-title: Functional endothelialized microvascular networks with circular cross‐sections in a tissue culture substrate publication-title: Biomed Microdevices – volume: 100 start-page: 5413 issue: 9 year: 2003 end-page: 5418 article-title: Synthetic matrix metalloproteinase‐sensitive hydrogels for the conduction of tissue regeneration: Engineering cell‐invasion characteristics publication-title: Proc Natl Acad Sci USA – volume: 4 start-page: 98 issue: 2 year: 2004 end-page: 103 article-title: Microfabrication and microfluidics for tissue engineering: State of the art and future opportunities publication-title: Lab Chip – volume: 103 start-page: 2480 issue: 8 year: 2006 end-page: 2487 article-title: Microscale technologies for tissue engineering and biology publication-title: Proc Natl Acad Sci USA – ident: e_1_2_7_27_1 doi: 10.1089/ten.2007.0196 – ident: e_1_2_7_13_1 doi: 10.1073/pnas.76.4.1882 – ident: e_1_2_7_23_1 doi: 10.1039/b814285h – ident: e_1_2_7_28_1 doi: 10.1155/2009/823148 – ident: e_1_2_7_29_1 doi: 10.1517/14712590903563352 – ident: e_1_2_7_10_1 doi: 10.1002/jbm.820251211 – ident: e_1_2_7_12_1 doi: 10.1002/adma.200900584 – ident: e_1_2_7_21_1 doi: 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| Snippet | Microscale technologies, such as microfluidic systems, provide powerful tools for building biomimetic vascular‐like structures for tissue engineering or in... Microscale technologies, such as microfluidic systems, provide powerful tools for building biomimetic vascular-like structures for tissue engineering or in... Microscale technologies, such as microfluidic systems, provide powerful tools for building biomimetic vascular-like structures for tissue engineering or in... |
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| Title | Sequential assembly of cell-laden hydrogel constructs to engineer vascular-like microchannels |
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