274-LB: Complement Factor D Contributes to Metabolic Dysregulation by Hepatic CD9 Deficiency

• Published in: Diabetes (New York, N.Y.) Vol. 72; no. Supplement_1; p. 1
• Main Author: ZHENG, YI
• Format: Journal Article
• Language: English
• Published: New York American Diabetes Association 20.06.2023
• Subjects: Adipocytes; Adipose tissue; AKT protein; CD9 antigen; Cell surface; Complement factor D; Diabetes; Diabetes mellitus; Energy expenditure; Fatty liver; Hepatocytes; Homeostasis; Lipogenesis; Liver; Metabolic disorders; Metabolism; Protein deficiency; Steatosis; Thermogenesis

Diabetes-induced metabolic diseases involve functional integration among inter-organ communication, and the liver is central to this process. Here we show that deficiency of cell-surface protein tetraspanin CD9 in the liver of diabetic mice stimulates hepatocytes to synthesize and secrete complement...