Glutamate-related gene expression changes with age in the mouse auditory midbrain

• Published in: Brain research Vol. 1127; no. 1; pp. 1 - 9
• Main Authors: Tadros, Sherif F., D'Souza, Mary, Zettel, Martha L., Zhu, XiaoXia, Waxmonsky, Nicole C., Frisina, Robert D.
• Format: Journal Article
• Language: English
• Published: London Elsevier B.V 05.01.2007; Amsterdam Elsevier; New York, NY
• Subjects: ABR; Aging; Aging - physiology; Animals; Auditory brainstem response; Biological and medical sciences; Disease Models, Animal; Distortion-product otoacoustic emissions; Down-Regulation - physiology; DPOAE; Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation; Excitatory Amino Acid Transporter 1 - genetics; Female; Functional hearing; Fundamental and applied biological sciences. Psychology; Gene expression; Gene Expression Profiling; Gene Expression Regulation - physiology; Glutamic Acid - metabolism; Inferior Colliculi - metabolism; Inferior Colliculi - physiopathology; Inferior colliculus; Male; Mice; Mice, Inbred CBA; Neurology; Neurotoxins - metabolism; Oligonucleotide Array Sequence Analysis; Ornithine-Oxo-Acid Transaminase - genetics; Presbycusis; Presbycusis - genetics; Presbycusis - metabolism; Presbycusis - physiopathology; Proline - biosynthesis; Real-time PCR; Up-Regulation - physiology; Vertebrates: nervous system and sense organs; AMPA; DPOAE; Inferior colliculus; IGF-1; Functional hearing; Gene expression; PRP; ABR; Auditory brainstem response; Real-time PCR; CAT; Aging; Slc1a3; GABA; NMDA; DPOAEs; Slc1a2; qPCR; Distortion-product otoacoustic emissions; GPE; Presbycusis; Pycs; Slc17a6; P5C; solute carrier family 17 member 6; solute carrier family 1 member 2; N-methyl- d-aspartate; solute carrier family 1 member 3; insulin-like growth factor-1; catalase enzyme; alpha amino-3-hydroxy-5-methyl-4-isoxazole propionic acid; glycine–proline–glutamate; proline-rich-polypeptide; gamma-aminobutyric acid; pyrroline-5-carboxylate; distortion product otoacoustic emissions; pyrroline-5-carboxylate synthetase enzyme; Senescence; Central nervous system; Electrophysiology; Encephalon; emissions; Age; Rodentia; Midbrain; Glutamate; Distortion-product otoacoustic; Polymerase chain reaction; Vertebrata; Hearing; Mammalia; Colliculus inferior; Mouse; Animal; Auditory evoked potential; Excitatory aminoacid; Neurotransmitter; Perception; Auditory pathway

Glutamate is the main excitatory neurotransmitter in both the peripheral and central auditory systems. Changes of glutamate and glutamate-related genes with age may be an important factor in the pathogenesis of age-related hearing loss—presbycusis. In this study, changes in glutamate-related mRNA ge...