The effect of uncertainty in patient classification on diagnostic performance estimations

• Published in: PloS one Vol. 14; no. 5; p. e0217146
• Main Authors: McHugh, Leo C, Snyder, Kevin, Yager, Thomas D
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 22.05.2019; Public Library of Science (PLoS)
• Subjects: Clinical trials; Computer and Information Sciences; Computer Simulation; Diagnostic Tests, Routine - standards; Diagnostic Tests, Routine - statistics & numerical data; Engineering and Technology; Humans; Medical tests; Medicine and Health Sciences; Models, Statistical; Performance-based assessment; Research and Analysis Methods; ROC Curve; Sepsis - classification; Sepsis - diagnosis; Uncertainty

The performance of a new diagnostic test is typically evaluated against a comparator which is assumed to correspond closely to some true state of interest. Judgments about the new test's performance are based on the differences between the outputs of the test and comparator. It is commonly assu...