Study of surface modification strategies to create glassy carbon-supported, aptamer-based sensors for continuous molecular monitoring

Electrochemical, aptamer-based (E-AB) sensors uniquely enable reagentless, reversible, and continuous molecular monitoring in biological fluids. Because of this ability, E-AB sensors have been proposed for therapeutic drug monitoring. However, to achieve translation from the bench to the clinic, E-A...

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Published inAnalytical and bioanalytical chemistry Vol. 414; no. 18; pp. 5627 - 5641
Main Authors Pellitero, Miguel Aller, Arroyo-Currás, Netzahualcóyotl
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer Berlin Heidelberg 01.07.2022
Springer
Springer Nature B.V
Subjects
Aliphatic amines
Alkanes
Amines
Analytical Chemistry
Aptamers
Aptamers, Nucleotide - chemistry
Biochemistry
Biomonitoring
Biosensing Techniques - methods
Bonding strength
Carbon
Characterization and Evaluation of Materials
Chemical detectors
Chemical properties
Chemical sensors
Chemistry
Chemistry and Materials Science
complementary DNA
Covalent bonds
Deoxyribonucleic acid
desorption
DNA
drugs
electric potential difference
Electrochemical Techniques - methods
Electrochemistry
Electrodes
Food Science
Glassy carbon
Gold
Gold - chemistry
Interfaces
Interrogation
Laboratory Medicine
Materials
Monitoring/Environmental Analysis
Monolayers
nucleotide aptamers
Oligomers
Promising Early-Career (Bio)Analytical Researchers
Research Paper
Self-assembly
Sensors
Stability
Substrates
Sulfhydryl Compounds - chemistry
Tethering
Therapeutic drug monitoring
therapeutics
voltammetry
United States
Electrooxidation
Carbon biosensors
Diazonium salts
Continuous biosensing
Aptamer-based sensing
Amine grafting
Online AccessGet full text
ISSN1618-2642
1618-2650
1618-2650
DOI10.1007/s00216-022-04015-5

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Abstract Electrochemical, aptamer-based (E-AB) sensors uniquely enable reagentless, reversible, and continuous molecular monitoring in biological fluids. Because of this ability, E-AB sensors have been proposed for therapeutic drug monitoring. However, to achieve translation from the bench to the clinic, E-AB sensors should ideally operate reliably and continuously for periods of days. Instead, because these sensors are typically fabricated on gold surfaces via self-assembly of alkanethiols that are prone to desorption from electrode surfaces, they undergo significant signal losses in just hours. To overcome this problem, our group is attempting to migrate E-AB sensor interfaces away from thiol-on-gold assembly towards stronger covalent bonds. Here, we explore the modification of carbon electrodes as an alternative substrate for E-AB sensors. We investigated three strategies to functionalize carbon surfaces: (I) anodization to generate surface carboxylic groups, (II) electrografting of arenediazonium ions, and (III) electrografting of primary aliphatic amines. Our results indicate that electrografting of primary aliphatic amines is the only strategy achieving monolayer organization and packing densities closely comparable to those obtained by alkanethiols on gold. In addition, the resulting monolayers enable covalent tethering of DNA aptamers and support electrochemical sensing of small molecule targets or complimentary DNA strands. These monolayers also achieve superior stability under continuous voltammetric interrogation in biological fluids relative to benchmark thiol-on-gold monolayers when a positive voltage scan window is used. Based on these results, we postulate the electrografting of primary aliphatic amines as a path forward to develop carbon-supported E-AB sensors with increased operational stability. Graphical abstract
AbstractList Electrochemical, aptamer-based (E-AB) sensors uniquely enable reagentless, reversible, and continuous molecular monitoring in biological fluids. Because of this ability, E-AB sensors have been proposed for therapeutic drug monitoring. However, to achieve translation from the bench to the clinic, E-AB sensors should ideally operate reliably and continuously for periods of days. Instead, because these sensors are typically fabricated on gold surfaces via self-assembly of alkanethiols that are prone to desorption from electrode surfaces, they undergo significant signal losses in just hours. To overcome this problem, our group is attempting to migrate E-AB sensor interfaces away from thiol-on-gold assembly towards stronger covalent bonds. Here, we explore the modification of carbon electrodes as an alternative substrate for E-AB sensors. We investigated three strategies to functionalize carbon surfaces: (I) anodization to generate surface carboxylic groups, (II) electrografting of arenediazonium ions, and (III) electrografting of primary aliphatic amines. Our results indicate that electrografting of primary aliphatic amines is the only strategy achieving monolayer organization and packing densities closely comparable to those obtained by alkanethiols on gold. In addition, the resulting monolayers enable covalent tethering of DNA aptamers and support electrochemical sensing of small molecule targets or complimentary DNA strands. These monolayers also achieve superior stability under continuous voltammetric interrogation in biological fluids relative to benchmark thiol-on-gold monolayers when a positive voltage scan window is used. Based on these results, we postulate the electrografting of primary aliphatic amines as a path forward to develop carbon-supported E-AB sensors with increased operational stability. Graphical abstract
Electrochemical, aptamer-based (E-AB) sensors uniquely enable reagentless, reversible, and continuous molecular monitoring in biological fluids. Because of this ability, E-AB sensors have been proposed for therapeutic drug monitoring. However, to achieve translation from the bench to the clinic, E-AB sensors should ideally operate reliably and continuously for periods of days. Instead, because these sensors are typically fabricated on gold surfaces via self-assembly of alkanethiols that are prone to desorption from electrode surfaces, they undergo significant signal losses in just hours. To overcome this problem, our group is attempting to migrate E-AB sensor interfaces away from thiol-on-gold assembly towards stronger covalent bonds. Here, we explore the modification of carbon electrodes as an alternative substrate for E-AB sensors. We investigated three strategies to functionalize carbon surfaces: (I) anodization to generate surface carboxylic groups, (II) electrografting of arenediazonium ions, and (III) electrografting of primary aliphatic amines. Our results indicate that electrografting of primary aliphatic amines is the only strategy achieving monolayer organization and packing densities closely comparable to those obtained by alkanethiols on gold. In addition, the resulting monolayers enable covalent tethering of DNA aptamers and support electrochemical sensing of small molecule targets or complimentary DNA strands. These monolayers also achieve superior stability under continuous voltammetric interrogation in biological fluids relative to benchmark thiol-on-gold monolayers when a positive voltage scan window is used. Based on these results, we postulate the electrografting of primary aliphatic amines as a path forward to develop carbon-supported E-AB sensors with increased operational stability.Electrochemical, aptamer-based (E-AB) sensors uniquely enable reagentless, reversible, and continuous molecular monitoring in biological fluids. Because of this ability, E-AB sensors have been proposed for therapeutic drug monitoring. However, to achieve translation from the bench to the clinic, E-AB sensors should ideally operate reliably and continuously for periods of days. Instead, because these sensors are typically fabricated on gold surfaces via self-assembly of alkanethiols that are prone to desorption from electrode surfaces, they undergo significant signal losses in just hours. To overcome this problem, our group is attempting to migrate E-AB sensor interfaces away from thiol-on-gold assembly towards stronger covalent bonds. Here, we explore the modification of carbon electrodes as an alternative substrate for E-AB sensors. We investigated three strategies to functionalize carbon surfaces: (I) anodization to generate surface carboxylic groups, (II) electrografting of arenediazonium ions, and (III) electrografting of primary aliphatic amines. Our results indicate that electrografting of primary aliphatic amines is the only strategy achieving monolayer organization and packing densities closely comparable to those obtained by alkanethiols on gold. In addition, the resulting monolayers enable covalent tethering of DNA aptamers and support electrochemical sensing of small molecule targets or complimentary DNA strands. These monolayers also achieve superior stability under continuous voltammetric interrogation in biological fluids relative to benchmark thiol-on-gold monolayers when a positive voltage scan window is used. Based on these results, we postulate the electrografting of primary aliphatic amines as a path forward to develop carbon-supported E-AB sensors with increased operational stability.
Electrochemical, aptamer-based (E-AB) sensors uniquely enable reagentless, reversible, and continuous molecular monitoring in biological fluids. Because of this ability, E-AB sensors have been proposed for therapeutic drug monitoring. However, to achieve translation from the bench to the clinic, E-AB sensors should ideally operate reliably and continuously for periods of days. Instead, because these sensors are typically fabricated on gold surfaces via self-assembly of alkanethiols that are prone to desorption from electrode surfaces, they undergo significant signal losses in just hours. To overcome this problem, our group is attempting to migrate E-AB sensor interfaces away from thiol-on-gold assembly towards stronger covalent bonds. Here, we explore the modification of carbon electrodes as an alternative substrate for E-AB sensors. We investigated three strategies to functionalize carbon surfaces: (I) anodization to generate surface carboxylic groups, (II) electrografting of arenediazonium ions, and (III) electrografting of primary aliphatic amines. Our results indicate that electrografting of primary aliphatic amines is the only strategy achieving monolayer organization and packing densities closely comparable to those obtained by alkanethiols on gold. In addition, the resulting monolayers enable covalent tethering of DNA aptamers and support electrochemical sensing of small molecule targets or complimentary DNA strands. These monolayers also achieve superior stability under continuous voltammetric interrogation in biological fluids relative to benchmark thiol-on-gold monolayers when a positive voltage scan window is used. Based on these results, we postulate the electrografting of primary aliphatic amines as a path forward to develop carbon-supported E-AB sensors with increased operational stability.
Electrochemical, aptamer-based (E-AB) sensors uniquely enable reagentless, reversible, and continuous molecular monitoring in biological fluids. Because of this ability, E-AB sensors have been proposed for therapeutic drug monitoring. However, to achieve translation from the bench to the clinic, E-AB sensors should ideally operate reliably and continuously for periods of days. Instead, because these sensors are typically fabricated on gold surfaces via self-assembly of alkanethiols that are prone to desorption from electrode surfaces, they undergo significant signal losses in just hours. To overcome this problem, our group is attempting to migrate E-AB sensor interfaces away from thiol-on-gold assembly towards stronger covalent bonds. Here, we explore the modification of carbon electrodes as an alternative substrate for E-AB sensors. We investigated three strategies to functionalize carbon surfaces: (I) anodization to generate surface carboxylic groups, (II) electrografting of arenediazonium ions, and (III) electrografting of primary aliphatic amines. Our results indicate that electrografting of primary aliphatic amines is the only strategy achieving monolayer organization and packing densities closely comparable to those obtained by alkanethiols on gold. In addition, the resulting monolayers enable covalent tethering of DNA aptamers and support electrochemical sensing of small molecule targets or complimentary DNA strands. These monolayers also achieve superior stability under continuous voltammetric interrogation in biological fluids relative to benchmark thiol-on-gold monolayers when a positive voltage scan window is used. Based on these results, we postulate the electrografting of primary aliphatic amines as a path forward to develop carbon-supported E-AB sensors with increased operational stability. Graphical abstract
Abstract Electrochemical, aptamer-based (E-AB) sensors uniquely enable reagentless, reversible, and continuous molecular monitoring in biological fluids. Because of this ability, E-AB sensors have been proposed for therapeutic drug monitoring. However, to achieve translation from the bench to the clinic, E-AB sensors should ideally operate reliably and continuously for periods of days. Instead, because these sensors are typically fabricated on gold surfaces via self-assembly of alkanethiols that are prone to desorption from electrode surfaces, they undergo significant signal losses in just hours. To overcome this problem, our group is attempting to migrate E-AB sensor interfaces away from thiol-on-gold assembly towards stronger covalent bonds. Here, we explore the modification of carbon electrodes as an alternative substrate for E-AB sensors. We investigated three strategies to functionalize carbon surfaces: (I) anodization to generate surface carboxylic groups, (II) electrografting of arenediazonium ions, and (III) electrografting of primary aliphatic amines. Our results indicate that electrografting of primary aliphatic amines is the only strategy achieving monolayer organization and packing densities closely comparable to those obtained by alkanethiols on gold. In addition, the resulting monolayers enable covalent tethering of DNA aptamers and support electrochemical sensing of small molecule targets or complimentary DNA strands. These monolayers also achieve superior stability under continuous voltammetric interrogation in biological fluids relative to benchmark thiol-on-gold monolayers when a positive voltage scan window is used. Based on these results, we postulate the electrografting of primary aliphatic amines as a path forward to develop carbon-supported E-AB sensors with increased operational stability.
Audience Academic
Author Pellitero, Miguel Aller
Arroyo-Currás, Netzahualcóyotl
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  organization: Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Department of Chemical and Biomolecular Engineering, Johns Hopkins University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/35352164$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1039/b714449k
10.1021/jp054513+
10.1088/0957-4484/17/19/006
10.1021/acssensors.7b00787
10.3390/s20082246
10.1016/j.coelec.2021.100902
10.1038/ncomms5348
10.1021/acs.analchem.7b02830
10.1021/la047369c
10.1016/j.tibtech.2014.04.005
10.1021/acs.analchem.9b02553
10.1021/acsami.9b22385
10.1149/1.2086794
10.1016/j.tibtech.2010.10.005
10.1016/j.mee.2008.11.045
10.1021/acssensors.9b01616
10.1021/acsptsci.8b00033
10.3390/molecules25194575
10.1021/acs.analchem.0c05024
10.1016/j.biotechadv.2009.12.004
10.1021/acssensors.1c01183
10.1002/anie.201700748
10.1039/C9SC01495K
10.1021/jacs.6b08671
10.1021/ac00250a038
10.1021/la00027a037
10.1073/pnas.1613458114
10.1021/ac00273a052
10.1038/s41557-019-0216-y
10.1149/2.0292003JES
10.1021/acssensors.0c02455
10.1016/j.elecom.2018.06.012
10.1016/j.teac.2017.02.001
10.1021/la00016a054
10.1021/acs.jpcc.1c00336
10.3389/fmolb.2019.00069
10.1016/j.electacta.2007.12.044
10.1016/j.snb.2008.03.015
10.1021/ja902573e
10.1039/C9SC04434E
10.1016/j.carbon.2006.09.034
10.1126/science.283.5408.1727
10.1021/la500533f
10.1021/cm0504182
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Issue 18
Keywords Electrooxidation
Carbon biosensors
Diazonium salts
Continuous biosensing
Aptamer-based sensing
Amine grafting
Language English
License 2022. The Author(s).
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References Fischer, Tenje, Heiskanen, Masuda, Castillo, Bentien (CR38) 2009; 86
Plaxco, Soh (CR6) 2011; 29
Pellitero, Curtis, Arroyo-Currás (CR18) 2021; 6
Barbier, Pinson, Desarmot, Sanchez (CR35) 1990; 137
Brothers, Moore, St. Lawrence, Harris, Joseph, Ratcliff (CR40) 2020; 20
Yamazaki, Siroma, Ioroi, Tanimoto, Yasuda (CR32) 2007; 45
Bhairamadgi, Pujari, Trovela, Debrassi, Khamis, Alonso (CR24) 2014; 30
Mahlum, Pellitero, Arroyo-Currás (CR41) 2021; 125
Bandodkar, Wang (CR4) 2014; 32
Pellitero, Shaver, Arroyo-Currás (CR8) 2020; 167
Xue, Li, Li, Zhang (CR20) 2014; 5
Wang, Sandberg, Kenny (CR23) 2006; 17
Laforgue, Addou, Bélanger (CR34) 2005; 21
Phal, Shimizu, Mwanza, Mashazi, Shchukarev, Tesfalidet (CR46) 2020; 25
Ferguson Brian, Hoggarth David, Maliniak, Ploense, White Ryan, Woodward (CR28) 2013; 5
Dauphin-Ducharme, Yang, Arroyo-Currás, Ploense, Zhang, Gerson (CR5) 2019; 4
Li, Arroyo-Currás, Kang, Ricci, Plaxco (CR27) 2016; 138
Arroyo-Currás, Somerson, Vieira, Ploense, Kippin, Plaxco (CR7) 2017; 114
Shaver, Curtis, Arroyo-Currás (CR25) 2020; 12
Ravichandran, Baldwin (CR31) 1984; 56
Baranton, Bélanger (CR33) 2005; 109
Li, Li, Dai, Li, Zhu, Li (CR13) 2019; 10
Streeter, Wildgoose, Shao, Compton (CR43) 2008; 133
Ronkainen, Halsall, Heineman (CR1) 2010; 39
Idili, Gerson, Kippin, Plaxco (CR15) 2021; 93
Leung, Downs, Ortega, Kurnik, Plaxco (CR17) 2021; 6
Curtis, Ploense, Kurnik, Ortega, Parolo, Kippin (CR29) 2019; 91
Fanjul-Bolado, Hernández-Santos, Lamas-Ardisana, Martín-Pernía, Costa-García (CR37) 2008; 53
Velusamy, Arshak, Korostynska, Oliwa, Adley (CR2) 2010; 28
Maduraiveeran, Jin (CR3) 2017; 13
Engstrom (CR30) 1982; 54
Shaver, Arroyo-Currás (CR16) 2022; 32
Arroyo-Currás, Scida, Ploense, Kippin, Plaxco (CR9) 2017; 89
CR42
Grandbois, Beyer, Rief, Clausen-Schaumann, Gaub (CR21) 1999; 283
Qi, Qin, Zhang, Zhang (CR22) 2009; 131
Sagara, Niki (CR44) 1993; 9
Arroyo-Currás, Dauphin-Ducharme, Ortega, Ploense, Kippin, Plaxco (CR11) 2018; 3
Arroyo-Currás, Ortega, Copp, Ploense, Plaxco, Kippin (CR10) 2018; 1
Pellitero, Colina, Villa, del Campo (CR39) 2018; 93
Idili, Arroyo-Currás, Ploense, Csordas, Kuwahara, Kippin (CR12) 2019; 10
Inkpen, Liu, Li, Campos, Neaton, Venkataraman (CR19) 2019; 11
Deinhammer, Ho, Anderegg, Porter (CR36) 1994; 10
Li, Dauphin-Ducharme, Arroyo-Currás, Tran, Vieira, Li (CR26) 2017; 56
Yan, Zhang, Gong, Su, Guo, Mao (CR45) 2005; 17
Vieira, Shin, Arroyo-Currás, Ortega, Li, Keller (CR14) 2019; 6
AJ Bandodkar (4015_CR4) 2014; 32
A Idili (4015_CR12) 2019; 10
MC Brothers (4015_CR40) 2020; 20
KW Plaxco (4015_CR6) 2011; 29
N Arroyo-Currás (4015_CR10) 2018; 1
S-i Yamazaki (4015_CR32) 2007; 45
SD Curtis (4015_CR29) 2019; 91
NS Bhairamadgi (4015_CR24) 2014; 30
I Streeter (4015_CR43) 2008; 133
JD Mahlum (4015_CR41) 2021; 125
H Li (4015_CR13) 2019; 10
S Baranton (4015_CR33) 2005; 109
4015_CR42
S Phal (4015_CR46) 2020; 25
T Sagara (4015_CR44) 1993; 9
S Ferguson Brian (4015_CR28) 2013; 5
PA Vieira (4015_CR14) 2019; 6
M Grandbois (4015_CR21) 1999; 283
NJ Ronkainen (4015_CR1) 2010; 39
B Barbier (4015_CR35) 1990; 137
MS Inkpen (4015_CR19) 2019; 11
H Li (4015_CR27) 2016; 138
LM Fischer (4015_CR38) 2009; 86
A Shaver (4015_CR16) 2022; 32
N Arroyo-Currás (4015_CR7) 2017; 114
P Dauphin-Ducharme (4015_CR5) 2019; 4
GM Wang (4015_CR23) 2006; 17
KK Leung (4015_CR17) 2021; 6
H Li (4015_CR26) 2017; 56
N Arroyo-Currás (4015_CR9) 2017; 89
Y Xue (4015_CR20) 2014; 5
Y Yan (4015_CR45) 2005; 17
MA Pellitero (4015_CR18) 2021; 6
A Laforgue (4015_CR34) 2005; 21
A Shaver (4015_CR25) 2020; 12
MA Pellitero (4015_CR8) 2020; 167
RC Engstrom (4015_CR30) 1982; 54
K Ravichandran (4015_CR31) 1984; 56
MA Pellitero (4015_CR39) 2018; 93
A Idili (4015_CR15) 2021; 93
V Velusamy (4015_CR2) 2010; 28
G Maduraiveeran (4015_CR3) 2017; 13
Y Qi (4015_CR22) 2009; 131
P Fanjul-Bolado (4015_CR37) 2008; 53
RS Deinhammer (4015_CR36) 1994; 10
N Arroyo-Currás (4015_CR11) 2018; 3
References_xml – volume: 39
  start-page: 1747
  issue: 5
  year: 2010
  end-page: 1763
  ident: CR1
  article-title: Electrochemical biosensors
  publication-title: Chem Soc Rev
  doi: 10.1039/b714449k
– volume: 109
  start-page: 24401
  issue: 51
  year: 2005
  end-page: 24410
  ident: CR33
  article-title: Electrochemical derivatization of carbon surface by reduction of in situ generated diazonium cations
  publication-title: J Phys Chem B
  doi: 10.1021/jp054513+
– volume: 17
  start-page: 4819
  issue: 19
  year: 2006
  end-page: 4824
  ident: CR23
  article-title: Density functional study of a typical thiol tethered on a gold surface: ruptures under normal or parallel stretch
  publication-title: Nanotechnology
  doi: 10.1088/0957-4484/17/19/006
– volume: 3
  start-page: 360
  issue: 2
  year: 2018
  end-page: 366
  ident: CR11
  article-title: Subsecond-resolved molecular measurements in the living body using chronoamperometrically interrogated aptamer-based sensors
  publication-title: ACS Sens
  doi: 10.1021/acssensors.7b00787
– volume: 20
  start-page: 2246
  issue: 8
  year: 2020
  ident: CR40
  article-title: Impact of self-assembled monolayer design and electrochemical factors on impedance-based biosensing
  publication-title: Sensors
  doi: 10.3390/s20082246
– volume: 32
  start-page: 100902
  year: 2022
  ident: CR16
  article-title: The challenge of long-term stability for nucleic acid-based electrochemical sensors
  publication-title: Curr Opin Electrochem
  doi: 10.1016/j.coelec.2021.100902
– volume: 5
  start-page: 4348
  issue: 1
  year: 2014
  ident: CR20
  article-title: Quantifying thiol–gold interactions towards the efficient strength control
  publication-title: Nat Comm
  doi: 10.1038/ncomms5348
– volume: 89
  start-page: 12185
  issue: 22
  year: 2017
  end-page: 12191
  ident: CR9
  article-title: High surface area electrodes generated via electrochemical roughening improve the signaling of electrochemical aptamer-based biosensors
  publication-title: Anal Chem
  doi: 10.1021/acs.analchem.7b02830
– volume: 21
  start-page: 6855
  issue: 15
  year: 2005
  end-page: 6865
  ident: CR34
  article-title: Characterization of the deposition of organic molecules at the surface of gold by the electrochemical reduction of aryldiazonium cations
  publication-title: Langmuir
  doi: 10.1021/la047369c
– volume: 32
  start-page: 363
  issue: 7
  year: 2014
  end-page: 371
  ident: CR4
  article-title: Non-invasive wearable electrochemical sensors: a review
  publication-title: Trends Biotechnol
  doi: 10.1016/j.tibtech.2014.04.005
– volume: 91
  start-page: 12321
  issue: 19
  year: 2019
  end-page: 12328
  ident: CR29
  article-title: Open source software for the real-time control, processing, and visualization of high-volume electrochemical data
  publication-title: Anal Chem
  doi: 10.1021/acs.analchem.9b02553
– volume: 12
  start-page: 11214
  issue: 9
  year: 2020
  end-page: 11223
  ident: CR25
  article-title: Alkanethiol monolayer end groups affect the long-term operational stability and signaling of electrochemical, aptamer-based sensors in biological fluids
  publication-title: ACS Appl Mater Interfaces
  doi: 10.1021/acsami.9b22385
– volume: 137
  start-page: 1757
  issue: 6
  year: 1990
  end-page: 1764
  ident: CR35
  article-title: Electrochemical bonding of amines to carbon fiber surfaces toward improved carbon-epoxy composites
  publication-title: J Electrochem Soc
  doi: 10.1149/1.2086794
– volume: 29
  start-page: 1
  issue: 1
  year: 2011
  end-page: 5
  ident: CR6
  article-title: Switch-based biosensors: a new approach towards real-time, in vivo molecular detection
  publication-title: Trends Biotechnol
  doi: 10.1016/j.tibtech.2010.10.005
– volume: 86
  start-page: 1282
  issue: 4
  year: 2009
  end-page: 1285
  ident: CR38
  article-title: Gold cleaning methods for electrochemical detection applications
  publication-title: Microelectron Eng
  doi: 10.1016/j.mee.2008.11.045
– volume: 4
  start-page: 2832
  issue: 10
  year: 2019
  end-page: 2837
  ident: CR5
  article-title: Electrochemical aptamer-based sensors for improved therapeutic drug monitoring and high-precision, feedback-controlled drug delivery
  publication-title: ACS Sens
  doi: 10.1021/acssensors.9b01616
– volume: 1
  start-page: 110
  issue: 2
  year: 2018
  end-page: 118
  ident: CR10
  article-title: High-precision control of plasma drug levels using feedback-controlled dosing
  publication-title: ACS Pharmacol Transl Sci
  doi: 10.1021/acsptsci.8b00033
– volume: 25
  start-page: 4575
  issue: 19
  year: 2020
  ident: CR46
  article-title: Electrografting of 4-carboxybenzenediazonium on glassy carbon electrode: the effect of concentration on the formation of mono and multilayers
  publication-title: Molecules
  doi: 10.3390/molecules25194575
– volume: 93
  start-page: 4023
  issue: 8
  year: 2021
  end-page: 4032
  ident: CR15
  article-title: Seconds-resolved, in situ measurements of plasma phenylalanine disposition kinetics in living rats
  publication-title: Anal Chem
  doi: 10.1021/acs.analchem.0c05024
– volume: 28
  start-page: 232
  issue: 2
  year: 2010
  end-page: 254
  ident: CR2
  article-title: An overview of foodborne pathogen detection: in the perspective of biosensors
  publication-title: Biotechnol Adv
  doi: 10.1016/j.biotechadv.2009.12.004
– volume: 6
  start-page: 3340
  issue: 9
  year: 2021
  end-page: 3347
  ident: CR17
  article-title: Elucidating the mechanisms underlying the signal drift of electrochemical aptamer-based sensors in whole blood
  publication-title: ACS Sens
  doi: 10.1021/acssensors.1c01183
– volume: 56
  start-page: 7492
  issue: 26
  year: 2017
  end-page: 7495
  ident: CR26
  article-title: A biomimetic phosphatidylcholine-terminated monolayer greatly improves the in vivo performance of electrochemical aptamer-based sensors
  publication-title: Angew Chem Int Ed
  doi: 10.1002/anie.201700748
– volume: 10
  start-page: 8164
  issue: 35
  year: 2019
  end-page: 8170
  ident: CR12
  article-title: Seconds-resolved pharmacokinetic measurements of the chemotherapeutic irinotecan in situ in the living body
  publication-title: Chem Sci
  doi: 10.1039/C9SC01495K
– volume: 138
  start-page: 15809
  issue: 49
  year: 2016
  end-page: 15812
  ident: CR27
  article-title: Dual-reporter drift correction to enhance the performance of electrochemical aptamer-based sensors in whole blood
  publication-title: J Am Chem Soc
  doi: 10.1021/jacs.6b08671
– ident: CR42
– volume: 54
  start-page: 2310
  issue: 13
  year: 1982
  end-page: 2314
  ident: CR30
  article-title: Electrochemical pretreatment of glassy carbon electrodes
  publication-title: Anal Chem
  doi: 10.1021/ac00250a038
– volume: 9
  start-page: 831
  issue: 3
  year: 1993
  end-page: 838
  ident: CR44
  article-title: Surface processes and adsorption states of methylene blue at graphite electrode surfaces in an acidic medium: an electroreflectance study
  publication-title: Langmuir
  doi: 10.1021/la00027a037
– volume: 114
  start-page: 645
  issue: 4
  year: 2017
  ident: CR7
  article-title: Real-time measurement of small molecules directly in awake, ambulatory animals
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1613458114
– volume: 56
  start-page: 1744
  issue: 9
  year: 1984
  end-page: 1747
  ident: CR31
  article-title: Enhanced voltammetric response by electrochemical pretreatment of carbon paste electrodes
  publication-title: Anal Chem
  doi: 10.1021/ac00273a052
– volume: 11
  start-page: 351
  issue: 4
  year: 2019
  end-page: 358
  ident: CR19
  article-title: Non-chemisorbed gold–sulfur binding prevails in self-assembled monolayers
  publication-title: Nat Chem
  doi: 10.1038/s41557-019-0216-y
– volume: 167
  start-page: 037529
  issue: 3
  year: 2020
  ident: CR8
  article-title: Critical review—approaches for the electrochemical interrogation of DNA-based sensors: a critical review
  publication-title: J Electrochem Soc
  doi: 10.1149/2.0292003JES
– volume: 6
  start-page: 1199
  issue: 3
  year: 2021
  end-page: 1207
  ident: CR18
  article-title: Interrogation of electrochemical aptamer-based sensors via peak-to-peak separation in cyclic voltammetry improves the temporal stability and batch-to-batch variability in biological fluids
  publication-title: ACS Sens
  doi: 10.1021/acssensors.0c02455
– volume: 93
  start-page: 123
  year: 2018
  end-page: 127
  ident: CR39
  article-title: Antimony tin oxide (ATO) screen-printed electrodes and their application to spectroelectrochemistry
  publication-title: Electrochem Comm
  doi: 10.1016/j.elecom.2018.06.012
– volume: 13
  start-page: 10
  year: 2017
  end-page: 23
  ident: CR3
  article-title: Nanomaterials based electrochemical sensor and biosensor platforms for environmental applications
  publication-title: Tren Environ Anal Chem
  doi: 10.1016/j.teac.2017.02.001
– volume: 10
  start-page: 1306
  issue: 4
  year: 1994
  end-page: 1313
  ident: CR36
  article-title: Electrochemical oxidation of amine-containing compounds: a route to the surface modification of glassy carbon electrodes
  publication-title: Langmuir
  doi: 10.1021/la00016a054
– volume: 125
  start-page: 9038
  issue: 17
  year: 2021
  end-page: 9049
  ident: CR41
  article-title: Chemical equilibrium-based mechanism for the electrochemical reduction of DNA-bound methylene blue explains double redox waves in voltammetry
  publication-title: J Phys Chem C
  doi: 10.1021/acs.jpcc.1c00336
– volume: 6
  start-page: 69
  year: 2019
  ident: CR14
  article-title: Ultra-high-precision, in-vivo pharmacokinetic measurements highlight the need for and a route toward more highly personalized medicine
  publication-title: Front Mol Biosci
  doi: 10.3389/fmolb.2019.00069
– volume: 53
  start-page: 3635
  issue: 10
  year: 2008
  end-page: 3642
  ident: CR37
  article-title: Electrochemical characterization of screen-printed and conventional carbon paste electrodes
  publication-title: Electrochim Acta
  doi: 10.1016/j.electacta.2007.12.044
– volume: 133
  start-page: 462
  issue: 2
  year: 2008
  end-page: 466
  ident: CR43
  article-title: Cyclic voltammetry on electrode surfaces covered with porous layers: an analysis of electron transfer kinetics at single-walled carbon nanotube modified electrodes
  publication-title: Sens Actuators B Chem
  doi: 10.1016/j.snb.2008.03.015
– volume: 131
  start-page: 16418
  issue: 45
  year: 2009
  end-page: 16422
  ident: CR22
  article-title: Breaking mechanism of single molecular junctions formed by octanedithiol molecules and Au electrodes
  publication-title: J Am Chem Soc
  doi: 10.1021/ja902573e
– volume: 5
  start-page: 213ra165-213ra165
  issue: 213
  year: 2013
  ident: CR28
  article-title: Real-time, aptamer-based tracking of circulating therapeutic agents in living animals
  publication-title: Sci Transl Med
– volume: 10
  start-page: 10843
  issue: 47
  year: 2019
  end-page: 10848
  ident: CR13
  article-title: High frequency, calibration-free molecular measurements in situ in the living body
  publication-title: Chem Sci
  doi: 10.1039/C9SC04434E
– volume: 45
  start-page: 256
  issue: 2
  year: 2007
  end-page: 62
  ident: CR32
  article-title: Evaluation of the number of carboxyl groups on glassy carbon after modification by 3,4-dihydroxybenzylamine
  publication-title: Carbon
  doi: 10.1016/j.carbon.2006.09.034
– volume: 283
  start-page: 1727
  issue: 5408
  year: 1999
  end-page: 1730
  ident: CR21
  article-title: How strong is a covalent bond?
  publication-title: Science
  doi: 10.1126/science.283.5408.1727
– volume: 30
  start-page: 5829
  issue: 20
  year: 2014
  end-page: 5839
  ident: CR24
  article-title: Hydrolytic and thermal stability of organic monolayers on various inorganic substrates
  publication-title: Langmuir
  doi: 10.1021/la500533f
– volume: 17
  start-page: 3457
  issue: 13
  year: 2005
  end-page: 3463
  ident: CR45
  article-title: Adsorption of methylene blue dye onto carbon nanotubes: a route to an electrochemically functional nanostructure and its layer-by-layer assembled nanocomposite
  publication-title: Chem Mater
  doi: 10.1021/cm0504182
– volume: 30
  start-page: 5829
  issue: 20
  year: 2014
  ident: 4015_CR24
  publication-title: Langmuir
  doi: 10.1021/la500533f
– volume: 13
  start-page: 10
  year: 2017
  ident: 4015_CR3
  publication-title: Tren Environ Anal Chem
  doi: 10.1016/j.teac.2017.02.001
– volume: 109
  start-page: 24401
  issue: 51
  year: 2005
  ident: 4015_CR33
  publication-title: J Phys Chem B
  doi: 10.1021/jp054513+
– volume: 114
  start-page: 645
  issue: 4
  year: 2017
  ident: 4015_CR7
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1613458114
– volume: 6
  start-page: 3340
  issue: 9
  year: 2021
  ident: 4015_CR17
  publication-title: ACS Sens
  doi: 10.1021/acssensors.1c01183
– volume: 167
  start-page: 037529
  issue: 3
  year: 2020
  ident: 4015_CR8
  publication-title: J Electrochem Soc
  doi: 10.1149/2.0292003JES
– volume: 3
  start-page: 360
  issue: 2
  year: 2018
  ident: 4015_CR11
  publication-title: ACS Sens
  doi: 10.1021/acssensors.7b00787
– volume: 1
  start-page: 110
  issue: 2
  year: 2018
  ident: 4015_CR10
  publication-title: ACS Pharmacol Transl Sci
  doi: 10.1021/acsptsci.8b00033
– volume: 137
  start-page: 1757
  issue: 6
  year: 1990
  ident: 4015_CR35
  publication-title: J Electrochem Soc
  doi: 10.1149/1.2086794
– volume: 29
  start-page: 1
  issue: 1
  year: 2011
  ident: 4015_CR6
  publication-title: Trends Biotechnol
  doi: 10.1016/j.tibtech.2010.10.005
– volume: 283
  start-page: 1727
  issue: 5408
  year: 1999
  ident: 4015_CR21
  publication-title: Science
  doi: 10.1126/science.283.5408.1727
– volume: 93
  start-page: 123
  year: 2018
  ident: 4015_CR39
  publication-title: Electrochem Comm
  doi: 10.1016/j.elecom.2018.06.012
– volume: 6
  start-page: 1199
  issue: 3
  year: 2021
  ident: 4015_CR18
  publication-title: ACS Sens
  doi: 10.1021/acssensors.0c02455
– volume: 28
  start-page: 232
  issue: 2
  year: 2010
  ident: 4015_CR2
  publication-title: Biotechnol Adv
  doi: 10.1016/j.biotechadv.2009.12.004
– volume: 131
  start-page: 16418
  issue: 45
  year: 2009
  ident: 4015_CR22
  publication-title: J Am Chem Soc
  doi: 10.1021/ja902573e
– volume: 21
  start-page: 6855
  issue: 15
  year: 2005
  ident: 4015_CR34
  publication-title: Langmuir
  doi: 10.1021/la047369c
– volume: 86
  start-page: 1282
  issue: 4
  year: 2009
  ident: 4015_CR38
  publication-title: Microelectron Eng
  doi: 10.1016/j.mee.2008.11.045
– volume: 6
  start-page: 69
  year: 2019
  ident: 4015_CR14
  publication-title: Front Mol Biosci
  doi: 10.3389/fmolb.2019.00069
– volume: 12
  start-page: 11214
  issue: 9
  year: 2020
  ident: 4015_CR25
  publication-title: ACS Appl Mater Interfaces
  doi: 10.1021/acsami.9b22385
– volume: 56
  start-page: 1744
  issue: 9
  year: 1984
  ident: 4015_CR31
  publication-title: Anal Chem
  doi: 10.1021/ac00273a052
– volume: 39
  start-page: 1747
  issue: 5
  year: 2010
  ident: 4015_CR1
  publication-title: Chem Soc Rev
  doi: 10.1039/b714449k
– volume: 5
  start-page: 4348
  issue: 1
  year: 2014
  ident: 4015_CR20
  publication-title: Nat Comm
  doi: 10.1038/ncomms5348
– volume: 91
  start-page: 12321
  issue: 19
  year: 2019
  ident: 4015_CR29
  publication-title: Anal Chem
  doi: 10.1021/acs.analchem.9b02553
– ident: 4015_CR42
– volume: 32
  start-page: 100902
  year: 2022
  ident: 4015_CR16
  publication-title: Curr Opin Electrochem
  doi: 10.1016/j.coelec.2021.100902
– volume: 17
  start-page: 3457
  issue: 13
  year: 2005
  ident: 4015_CR45
  publication-title: Chem Mater
  doi: 10.1021/cm0504182
– volume: 11
  start-page: 351
  issue: 4
  year: 2019
  ident: 4015_CR19
  publication-title: Nat Chem
  doi: 10.1038/s41557-019-0216-y
– volume: 4
  start-page: 2832
  issue: 10
  year: 2019
  ident: 4015_CR5
  publication-title: ACS Sens
  doi: 10.1021/acssensors.9b01616
– volume: 17
  start-page: 4819
  issue: 19
  year: 2006
  ident: 4015_CR23
  publication-title: Nanotechnology
  doi: 10.1088/0957-4484/17/19/006
– volume: 45
  start-page: 256
  issue: 2
  year: 2007
  ident: 4015_CR32
  publication-title: Carbon
  doi: 10.1016/j.carbon.2006.09.034
– volume: 133
  start-page: 462
  issue: 2
  year: 2008
  ident: 4015_CR43
  publication-title: Sens Actuators B Chem
  doi: 10.1016/j.snb.2008.03.015
– volume: 138
  start-page: 15809
  issue: 49
  year: 2016
  ident: 4015_CR27
  publication-title: J Am Chem Soc
  doi: 10.1021/jacs.6b08671
– volume: 10
  start-page: 1306
  issue: 4
  year: 1994
  ident: 4015_CR36
  publication-title: Langmuir
  doi: 10.1021/la00016a054
– volume: 5
  start-page: 213ra165-213ra1
  issue: 213
  year: 2013
  ident: 4015_CR28
  publication-title: Sci Transl Med
– volume: 89
  start-page: 12185
  issue: 22
  year: 2017
  ident: 4015_CR9
  publication-title: Anal Chem
  doi: 10.1021/acs.analchem.7b02830
– volume: 9
  start-page: 831
  issue: 3
  year: 1993
  ident: 4015_CR44
  publication-title: Langmuir
  doi: 10.1021/la00027a037
– volume: 53
  start-page: 3635
  issue: 10
  year: 2008
  ident: 4015_CR37
  publication-title: Electrochim Acta
  doi: 10.1016/j.electacta.2007.12.044
– volume: 32
  start-page: 363
  issue: 7
  year: 2014
  ident: 4015_CR4
  publication-title: Trends Biotechnol
  doi: 10.1016/j.tibtech.2014.04.005
– volume: 56
  start-page: 7492
  issue: 26
  year: 2017
  ident: 4015_CR26
  publication-title: Angew Chem Int Ed
  doi: 10.1002/anie.201700748
– volume: 93
  start-page: 4023
  issue: 8
  year: 2021
  ident: 4015_CR15
  publication-title: Anal Chem
  doi: 10.1021/acs.analchem.0c05024
– volume: 25
  start-page: 4575
  issue: 19
  year: 2020
  ident: 4015_CR46
  publication-title: Molecules
  doi: 10.3390/molecules25194575
– volume: 10
  start-page: 8164
  issue: 35
  year: 2019
  ident: 4015_CR12
  publication-title: Chem Sci
  doi: 10.1039/C9SC01495K
– volume: 54
  start-page: 2310
  issue: 13
  year: 1982
  ident: 4015_CR30
  publication-title: Anal Chem
  doi: 10.1021/ac00250a038
– volume: 20
  start-page: 2246
  issue: 8
  year: 2020
  ident: 4015_CR40
  publication-title: Sensors
  doi: 10.3390/s20082246
– volume: 10
  start-page: 10843
  issue: 47
  year: 2019
  ident: 4015_CR13
  publication-title: Chem Sci
  doi: 10.1039/C9SC04434E
– volume: 125
  start-page: 9038
  issue: 17
  year: 2021
  ident: 4015_CR41
  publication-title: J Phys Chem C
  doi: 10.1021/acs.jpcc.1c00336
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Snippet Electrochemical, aptamer-based (E-AB) sensors uniquely enable reagentless, reversible, and continuous molecular monitoring in biological fluids. Because of...
Abstract Electrochemical, aptamer-based (E-AB) sensors uniquely enable reagentless, reversible, and continuous molecular monitoring in biological fluids....
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StartPage 5627
SubjectTerms Aliphatic amines
Alkanes
Amines
Analytical Chemistry
Aptamers
Aptamers, Nucleotide - chemistry
Biochemistry
Biomonitoring
Biosensing Techniques - methods
Bonding strength
Carbon
Characterization and Evaluation of Materials
Chemical detectors
Chemical properties
Chemical sensors
Chemistry
Chemistry and Materials Science
complementary DNA
Covalent bonds
Deoxyribonucleic acid
desorption
DNA
drugs
electric potential difference
Electrochemical Techniques - methods
Electrochemistry
Electrodes
Food Science
Glassy carbon
Gold
Gold - chemistry
Interfaces
Interrogation
Laboratory Medicine
Materials
Monitoring/Environmental Analysis
Monolayers
nucleotide aptamers
Oligomers
Promising Early-Career (Bio)Analytical Researchers
Research Paper
Self-assembly
Sensors
Stability
Substrates
Sulfhydryl Compounds - chemistry
Tethering
Therapeutic drug monitoring
therapeutics
voltammetry
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Title Study of surface modification strategies to create glassy carbon-supported, aptamer-based sensors for continuous molecular monitoring
URI https://link.springer.com/article/10.1007/s00216-022-04015-5
https://www.ncbi.nlm.nih.gov/pubmed/35352164
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Volume 414
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