Development and structural basis of a two-MAb cocktail for treating SARS-CoV-2 infections - Zhang, Chao; Wang, Yifan; Zhu, Yuanfei; Liu, Caixuan; Gu, Chenjian; Xu, Shiqi; Wang, Yalei; Zhou, Yu; Wang, Yanxing; Han, Wenyu; Hong, Xiaoyu; Yang, Yong; et al. (Nature communications, 2021)
Keywords: 101/28; 631/326; 631/535; 82/1; ACE2; Allosteric properties; Angiotensin-converting enzyme 2; Animals; Antibodies, Monoclonal - chemistry; Antibodies, Monoclonal - immunology; Antibodies, Monoclonal - pharmacology; Antibodies, Monoclonal - therapeutic use; Antibodies, Neutralizing - immunology; Antibodies, Viral - chemistry; Antibodies, Viral - immunology; Antibodies, Viral - pharmacology; Antibodies, Viral - therapeutic use; Antigens; Antiviral agents; Antiviral drugs; Binding; Coronaviridae; Coronaviruses; COVID-19; COVID-19 - drug therapy; Cryoelectron Microscopy; Drug development; Emerging diseases; Epitope Mapping; Epitopes; Female; Human health and pathology; Humanities and Social Sciences; Immunology; Immunotherapy; Infectious diseases; Life Sciences; Mice; Mice, Inbred BALB C; Microbiology and Parasitology; Models, Molecular; Monoclonal antibodies; multidisciplinary; Neutralizing; Pandemics; Prophylaxis; Protein Binding - drug effects; Protein Conformation; Proteins; Respiratory diseases; SARS-CoV-2 - drug effects; Science; Science (multidisciplinary); Severe acute respiratory syndrome coronavirus 2; Spike Glycoprotein, Coronavirus - chemistry; Spike Glycoprotein, Coronavirus - immunology; Spike protein; Trimers; Viral diseases; Virology