Acute radiation impacts contractility of guinea-pig bladder strips affecting mucosal-detrusor interactions

• Published in: PloS one Vol. 13; no. 3; p. e0193923
• Main Authors: McDonnell, Bronagh M, Buchanan, Paul J, Prise, Kevin M, McCloskey, Karen D
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 07.03.2018; Public Library of Science (PLoS)
• Subjects: Adenosine Triphosphate - pharmacology; Animals; Atropine - pharmacology; Biology and Life Sciences; Bladder; Calcium Signaling; Carbachol - pharmacology; Cystitis; Development and progression; Dose-Response Relationship, Radiation; Guinea Pigs; Health aspects; In Vitro Techniques; Male; Medical examination; Medicine and Health Sciences; Mucous Membrane - drug effects; Mucous Membrane - physiology; Muscle Contraction - drug effects; Muscle Contraction - radiation effects; Muscle, Smooth - drug effects; Muscle, Smooth - physiology; Muscle, Smooth - radiation effects; Physical Sciences; Radiation Dosage; Radiation exposure; Urinary Bladder - drug effects; Urinary Bladder - radiation effects

Radiation-induced bladder toxicity is associated with radiation therapy for pelvic malignancies, arising from unavoidable irradiation of neighbouring normal bladder tissue. This study aimed to investigate the acute impact of ionizing radiation on the contractility of bladder strips and identify the...