Neurexin 1 (NRXN1) splice isoform expression during human neocortical development and aging

• Published in: Molecular psychiatry Vol. 21; no. 5; pp. 701 - 706
• Main Authors: Jenkins, A K, Paterson, C, Wang, Y, Hyde, T M, Kleinman, J E, Law, A J
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.05.2016; Nature Publishing Group
• Subjects: 38; 38/39; 631/208; 631/337; 631/378; 692/699/476/1799; Adolescent; Adult; Aged; Aged, 80 and over; Aging; Aging - metabolism; Autism; Behavioral Sciences; Biological Psychology; Bipolar disorder; Bipolar Disorder - metabolism; Brain; Calcium-Binding Proteins; Cell adhesion & migration; Cell adhesion molecules; Cell Adhesion Molecules, Neuronal - metabolism; Child; Child, Preschool; Developmental biology; Female; Fetuses; Gene expression; Gestational age; Humans; Infant; Infant, Newborn; Intellectual disabilities; Isoforms; Life span; Male; Medical examination; Medicine; Medicine & Public Health; Mental disorders; Mental health; Middle Aged; Neocortex - growth & development; Neocortex - metabolism; Nerve Tissue Proteins - metabolism; Nervous system; Neural Cell Adhesion Molecules; Neurodevelopmental disorders; Neurosciences; Observations; original-article; Pharmacotherapy; Polymerase chain reaction; Prefrontal cortex; Properties; Protein Isoforms; Proteins; Psychiatry; Review boards; Schizophrenia; Schizophrenia - metabolism; Young Adult; United States > US; Baltimore Maryland

Neurexin 1 (NRXN1), a presynaptic cell adhesion molecule, is implicated in several neurodevelopmental disorders characterized by synaptic dysfunction including autism, intellectual disability and schizophrenia. To gain insight into NRXN1’s involvement in human cortical development we used quantitati...