A short-term transition from a high-fat diet to a normal-fat diet before pregnancy exacerbates female mouse offspring obesity

• Published in: International Journal of Obesity Vol. 40; no. 4; pp. 564 - 572
• Main Authors: Fu, Q, Olson, P, Rasmussen, D, Keith, B, Williamson, M, Zhang, K K, Xie, L
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.04.2016; Nature Publishing Group
• Subjects: 38/77; 631/1647/334/1874/345; 631/443/319/1642/393; 64/60; 692/163; 692/700/2814; 82/80; 96/1; 96/95; Adipocytes; Adipogenesis; Analysis; Animal models; Animals; Animals, Newborn - metabolism; Body weight loss; Breastfeeding & lactation; Diet; Diet, High-Fat; Dietary Fats - administration & dosage; Dietary Fats - pharmacology; Disease Models, Animal; Epidemiology; Female; Females; Fetus; Fetuses; Food science; Gene expression; Genes; Glucose; Glucose tolerance; Glucose transporter; Glycogen; Glycogens; Growth; Health aspects; Health Promotion and Disease Prevention; High fat diet; Insulin; Insulin receptor substrate 1; Internal Medicine; Intolerance; Ketogenic diet; Lactation; Lipogenesis; Liver; Male; Maternal Nutritional Physiological Phenomena - drug effects; Medical research; Medicine; Medicine & Public Health; Medicine, Experimental; Metabolic Diseases; Mice; Mothers; Nutrition research; Obesity; Obesity - etiology; Obesity - pathology; Obesity in children; Offspring; original-article; Overnutrition; Overweight; Pregnancy; Pregnant women; Prenatal Exposure Delayed Effects - etiology; Prenatal Exposure Delayed Effects - pathology; Prenatal influences; Prenatal Nutritional Physiological Phenomena - drug effects; Prevention; Public Health; Risk factors; Substrates; Weaning; Weight control; Weight loss; Women; Womens health; United States; United States > US; Texas

Background/Objectives: Recent findings have highlighted the detrimental influence of maternal overnutrition and obesity on fetal development and early life development. However, there are no evidence-based guidelines regarding the optimal strategy for dietary intervention before pregnancy. Subjects/...