High-throughput analysis of lung immune cells in a combined murine model of agriculture dust-triggered airway inflammation with rheumatoid arthritis

• Published in: PloS one Vol. 16; no. 2; p. e0240707
• Main Authors: Gaurav, Rohit, Mikuls, Ted R, Thiele, Geoffrey M, Nelson, Amy J, Niu, Meng, Guda, Chittibabu, Eudy, James D, Barry, Austin E, Wyatt, Todd A, Romberger, Debra J, Duryee, Michael J, England, Bryant R, Poole, Jill A
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 12.02.2021; Public Library of Science (PLoS)
• Subjects: Agriculture; Animals; Arthritis, Experimental - immunology; Arthritis, Rheumatoid - complications; Arthritis, Rheumatoid - metabolism; Arthritis, Rheumatoid - physiopathology; Autoimmune Diseases - metabolism; Biology and Life Sciences; Complications and side effects; Disease Models, Animal; Dust - immunology; Genetic aspects; Health aspects; High-Throughput Screening Assays - methods; Inflammation - metabolism; Inflammation Mediators - metabolism; Lung - immunology; Lung - metabolism; Lung - pathology; Lung diseases; Lung Diseases - metabolism; Macrophages - metabolism; Male; Medicine and Health Sciences; Mice; Mice, Inbred DBA; Monocytes - metabolism; Myeloid-Derived Suppressor Cells - metabolism; Neutrophils - metabolism; Patient outcomes; Research and Analysis Methods; Respiratory tract infections; Rheumatoid arthritis; Risk factors; United States

Rheumatoid arthritis (RA)-associated lung disease is a leading cause of mortality in RA, yet the mechanisms linking lung disease and RA remain unknown. Using an established murine model of RA-associated lung disease combining collagen-induced arthritis (CIA) with organic dust extract (ODE)-induced a...