Three kinds of treatment with Homoharringtonine, Hydroxychloroquine or shRNA and their combination against coronavirus PEDV in vitro

• Published in: Virology journal Vol. 17; no. 1; p. 71
• Main Authors: Li, Cui-Cui, Wang, Xiao-Jia
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 03.06.2020; BioMed Central; BMC
• Subjects: Analysis; Animal husbandry; Antiviral activity; Antiviral agents; Antiviral drugs; antiviral properties; Coronaviridae; Coronavirus; Coronaviruses; Diarrhea; drugs; EDTA; financial economics; Health aspects; Heptad repeat; Homoharringtonine; Hydroxychloroquine; Immunomodulators; industry; PEDV; Plasmids; Porcine epidemic diarrhea virus; Pork industry; RNA; Short hairpin RNA; Swine; Transmissible gastroenteritis; Viral infections; viral load; virology; Viruses

Porcine epidemic diarrhea virus (PEDV) of the family Coronaviridae has caused substantial economic losses in the swine husbandry industry. There's currently no specific drug available for treatment of coronaviruses or PEDV. In the current study, we use coronavirus PEDV as a model to study antiv...