Histone H4K20 methylation mediated chromatin compaction threshold ensures genome integrity by limiting DNA replication licensing

• Published in: Nature communications Vol. 9; no. 1; pp. 3704 - 11
• Main Authors: Shoaib, Muhammad, Walter, David, Gillespie, Peter J., Izard, Fanny, Fahrenkrog, Birthe, Lleres, David, Lerdrup, Mads, Johansen, Jens Vilstrup, Hansen, Klaus, Julien, Eric, Blow, J. Julian, Sørensen, Claus S.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 12.09.2018; Nature Publishing Group; Nature Portfolio
• Subjects: 13/1; 13/106; 13/31; 13/89; 14/19; 14/28; 14/33; 45/23; 631/337/100/101; 631/80/458/1648; Biochemistry, Molecular Biology; Cell cycle; Cell Line, Tumor; Chromatin; Chromatin - genetics; Chromatin - metabolism; Compaction; Constraining; Deoxyribonucleic acid; DNA; DNA biosynthesis; DNA Damage; DNA Damage - genetics; DNA Damage - physiology; DNA methylation; DNA Replication; DNA Replication - genetics; DNA Replication - physiology; Flow Cytometry; G1 phase; Gene expression; Genomes; Genomics; Histone H4; Histones; Histones - genetics; Histones - metabolism; Humanities and Social Sciences; Humans; Integrity; Licenses; Licensing; Life Sciences; Lysine; Methylation; Microscopy, Fluorescence; Mitosis; multidisciplinary; Origin recognition complex; Overloading; Replication; RNA, Small Interfering; RNA, Small Interfering - genetics; Science; Science (multidisciplinary); Single-stranded DNA

The decompaction and re-establishment of chromatin organization immediately after mitosis is essential for genome regulation. Mechanisms underlying chromatin structure control in daughter cells are not fully understood. Here we show that a chromatin compaction threshold in cells exiting mitosis ensu...