Combination of anti-angiogenic therapy and immune checkpoint blockade normalizes vascular-immune crosstalk to potentiate cancer immunity

• Published in: Experimental & molecular medicine Vol. 52; no. 9; pp. 1475 - 1485
• Main Authors: Lee, Won Suk, Yang, Hannah, Chon, Hong Jae, Kim, Chan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.09.2020; Springer Nature B.V; Nature Publishing Group; 생화학분자생물학회
• Subjects: 13/1; 13/21; 13/31; 13/51; 631/67/327; 64/110; 64/60; 692/699/67/1059/2325; 692/699/67/1059/602; 692/699/67/2328; 692/699/67/580; Angiogenesis; Angiogenesis Inhibitors - administration & dosage; Animals; Antineoplastic Combined Chemotherapy Protocols - adverse effects; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biomedical and Life Sciences; Biomedicine; Blood vessels; Cancer; Cancer immunotherapy; CD4 antigen; CD8 antigen; Cell activation; Cell Communication - genetics; Cell Communication - immunology; Clinical trials; Dendritic cells; Endometrium; Humans; Immune checkpoint inhibitors; Immune Checkpoint Inhibitors - administration & dosage; Immunity (Disease); Immunomodulation - drug effects; Immunosuppressive agents; Immunotherapy; Kidneys; Liver cancer; Lung cancer; Lymphocytes T; Macrophages; Medical Biochemistry; Molecular Medicine; Molecular Targeted Therapy; Neoplasms - drug therapy; Neoplasms - etiology; Neoplasms - metabolism; Neoplasms - pathology; Neovascularization, Pathologic - drug therapy; Neovascularization, Pathologic - immunology; Neovascularization, Pathologic - metabolism; Patients; Review; Review Article; Signal Transduction; Stem Cells; Treatment Outcome; Tumor microenvironment; Tumor Microenvironment - drug effects; Tumor Microenvironment - genetics; Tumor Microenvironment - immunology; Tumors; Uterine cancer; Vascular endothelial growth factor; γ-Interferon; 생화학

Cancer immunotherapy with immune checkpoint inhibitors (ICIs) has revolutionized the treatment of advanced cancers. However, the tumor microenvironment (TME) functions as a formidable barrier that severely impairs the efficacy of ICIs. While the crosstalk between tumor vessels and immune cells deter...