Risk of Estrogen Receptor–Positive and –Negative Breast Cancer and Single–Nucleotide Polymorphism 2q35-rs13387042

• Published in: JNCI : Journal of the National Cancer Institute Vol. 101; no. 14; pp. 1012 - 1018
• Main Authors: Milne, Roger L., Benítez, Javier, Nevanlinna, Heli, Heikkinen, Tuomas, Aittomäki, Kristiina, Blomqvist, Carl, Arias, José Ignacio, Zamora, M. Pilar, Burwinkel, Barbara, Bartram, Claus R., Meindl, Alfons, Schmutzler, Rita K., Cox, Angela, Brock, Ian, Elliott, Graeme, Reed, Malcolm W. R., Southey, Melissa C., Smith, Letitia, Spurdle, Amanda B., Hopper, John L., Couch, Fergus J., Olson, Janet E., Wang, Xianshu, Fredericksen, Zachary, Schürmann, Peter, Bremer, Michael, Hillemanns, Peter, Dörk, Thilo, Devilee, Peter, van Asperen, Christie J., Tollenaar, Rob A. E. M., Seynaeve, Caroline, Hall, Per, Czene, Kamila, Liu, Jianjun, Li, Yuqing, Ahmed, Shahana, Dunning, Alison M., Maranian, Melanie, Pharoah, Paul D. P., Chenevix-Trench, Georgia, Beesley, Jonathan, Bogdanova, Natalia V., Antonenkova, Natalia N., Zalutsky, Iosif V., Anton-Culver, Hoda, Ziogas, Argyrios, Brauch, Hiltrud, Justenhoven, Christina, Ko, Yon-Dschun, Haas, Susanne, Fasching, Peter A., Strick, Reiner, Ekici, Arif B., Beckmann, Matthias W., Giles, Graham G., Severi, Gianluca, Baglietto, Laura, English, Dallas R., Fletcher, Olivia, Johnson, Nichola, dos Santos Silva, Isabel, Peto, Julian, Turnbull, Clare, Hines, Sarah, Renwick, Anthony, Rahman, Nazneen, Nordestgaard, Børge G., Bojesen, Stig E., Flyger, Henrik, Kang, Daehee, Yoo, Keun-Young, Noh, Dong-Young, Mannermaa, Arto, Kataja, Vesa, Kosma, Veli-Matti, García-Closas, Montserrat, Chanock, Stephen, Lissowska, Jolanta, Brinton, Louise A., Chang-Claude, Jenny, Wang-Gohrke, Shan, Shen, Chen-Yang, Wang, Hui-Chun, Yu, Jyh-Cherng, Chen, Sou-Tong, Bermisheva, Marina, Nikolaeva, Tatjana, Khusnutdinova, Elza, Humphreys, Manjeet K., Morrison, Jonathan, Platte, Radka, Easton, Douglas F.
• Format: Journal Article
• Language: English
• Published: Cary, NC Oxford University Press 15.07.2009; Oxford Publishing Limited (England)
• Subjects: Adult; Aged; Asian People - genetics; Biological and medical sciences; Biomarkers, Tumor - analysis; Breast cancer; Breast Neoplasms - chemistry; Breast Neoplasms - genetics; Breast Neoplasms - pathology; Carcinoma, Ductal, Breast - chemistry; Carcinoma, Ductal, Breast - genetics; Carcinoma, Intraductal, Noninfiltrating - chemistry; Carcinoma, Intraductal, Noninfiltrating - genetics; Case-Control Studies; Confidence Intervals; Confounding Factors, Epidemiologic; Estrogens; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Genotype & phenotype; Gynecology. Andrology. Obstetrics; Humans; Linkage Disequilibrium; Mammary gland diseases; Medical sciences; Middle Aged; Neoplasms, Hormone-Dependent - chemistry; Neoplasms, Hormone-Dependent - genetics; Odds Ratio; Oncology; Polymorphism; Polymorphism, Single Nucleotide; Receptors, Estrogen - analysis; Receptors, Progesterone - genetics; Risk factors; Tumors; White People - genetics; United States; North America; America; Human; Estrogen receptor; Breast disease; Genetic variability; Chromosome A2; Genotype; Breast cancer; Malignant tumor; Epidemiology; Mammary gland diseases; Cancerology; Risk factor; Cytogenetics; Genetics; Single nucleotide polymorphism; Public health; Cancer; Hormonal receptor

Background A recent genome-wide association study identified single-nucleotide polymorphism (SNP) 2q35-rs13387042 as a marker of susceptibility to estrogen receptor (ER)–positive breast cancer. We attempted to confirm this association using the Breast Cancer Association Consortium. Methods 2q35-rs13...