PTEN self-regulates through USP11 via the PI3K-FOXO pathway to stabilize tumor suppression - Park, Mi Kyung; Yao, Yixin; Xia, Weiya; Setijono, Stephanie Rebecca; Kim, Jae Hwan; Vila, Isabelle K.; Chiu, Hui-Hsuan; Wu, Yun; Billalabeitia, Enrique González; Lee, Min Gyu; Kalb, Robert G.; Hung, Mien-Chie; et al. (Nature communications, 2019)
Keywords: 1-Phosphatidylinositol 3-kinase; 631/67/1244; 631/80/474/2289; 64/60; 96/95; AKT protein; Animals; Cancer; Cells, Cultured; Forkhead protein; Forkhead Transcription Factors - genetics; Forkhead Transcription Factors - metabolism; Gene Expression Regulation, Neoplastic - genetics; Gene Expression Regulation, Neoplastic - physiology; Humanities and Social Sciences; Life Sciences; Lipids; Localization; Magnetic Resonance Imaging; Male; Metastases; Mice; Mice, Knockout; Mice, Nude; multidisciplinary; Phosphatase; Phosphatidylinositol 3-Kinases - genetics; Phosphatidylinositol 3-Kinases - metabolism; PTEN Phosphohydrolase - genetics; PTEN Phosphohydrolase - metabolism; PTEN protein; Science; Science (multidisciplinary); Signal Transduction - genetics; Signal Transduction - physiology; Stability; Thiolester Hydrolases - genetics; Thiolester Hydrolases - metabolism; Transcription; Tumor suppressor genes; Tumors