The Wnt signaling pathway in tumorigenesis, pharmacological targets, and drug development for cancer therapy

• Published in: Biomarker research Vol. 9; no. 1; pp. 1 - 16
• Main Authors: Wang, Zhuo, Zhao, Tingting, Zhang, Shihui, Wang, Junkai, Chen, Yunyun, Zhao, Hongzhou, Yang, Yaxin, Shi, Songlin, Chen, Qiang, Liu, Kuancan
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 06.09.2021; BioMed Central; BMC
• Subjects: Antimitotic agents; Antineoplastic agents; beta-catenin; Cancer; Cancer therapies; Cell growth; Clinical trials; Development and progression; Drug delivery; Drug development; Drug therapy; Epigenetic modification; Epigenetics; Esophageal cancer; Gene mutations; Health aspects; Homeostasis; Immune response; Immunosuppressive agents; Kinases; Mutation; Point mutation; Prognosis; Review; Signal transduction; Tumor microenvironment; Tumorigenesis; Wnt protein; Wnt signaling; β-Catenin

Wnt signaling was initially recognized to be vital for tissue development and homeostasis maintenance. Further studies revealed that this pathway is also important for tumorigenesis and progression. Abnormal expression of signaling components through gene mutation or epigenetic regulation is closely...