Beta-amyloid deposition in chronic traumatic encephalopathy

• Published in: Acta neuropathologica Vol. 130; no. 1; pp. 21 - 34
• Main Authors: Stein, Thor D., Montenigro, Philip H., Alvarez, Victor E., Xia, Weiming, Crary, John F., Tripodis, Yorghos, Daneshvar, Daniel H., Mez, Jesse, Solomon, Todd, Meng, Gaoyuan, Kubilus, Caroline A., Cormier, Kerry A., Meng, Steven, Babcock, Katharine, Kiernan, Patrick, Murphy, Lauren, Nowinski, Christopher J., Martin, Brett, Dixon, Diane, Stern, Robert A., Cantu, Robert C., Kowall, Neil W., McKee, Ann C.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.07.2015; Springer; Springer Nature B.V
• Subjects: Adult; Age Factors; Aged; Aged, 80 and over; Alzheimer's disease; Amyloid beta-Peptides - metabolism; Apolipoprotein E4 - genetics; Athletes; Athletic Injuries - epidemiology; Athletic Injuries - genetics; Athletic Injuries - metabolism; Athletic Injuries - pathology; Brain; Brain - metabolism; Brain - pathology; Brain Injury, Chronic - epidemiology; Brain Injury, Chronic - genetics; Brain Injury, Chronic - metabolism; Brain Injury, Chronic - pathology; Chronic brain injury; Chronic traumatic encephalopathy; Clinical outcomes; Cohort Studies; Comorbidity; Dementia; Diagnosis; Encephalopathy; Humans; Medicine; Medicine & Public Health; Middle Aged; Nervous system diseases; Neurodegenerative Diseases - epidemiology; Neurodegenerative Diseases - genetics; Neurodegenerative Diseases - metabolism; Neurodegenerative Diseases - pathology; Neurophysiology; Neurosciences; Neurosurgery; Original Paper; Pathology; Plaque, Amyloid - etiology; Plaque, Amyloid - metabolism; Plaque, Amyloid - pathology; Postconcussional syndrome; Severity of Illness Index; tau Proteins - metabolism; Traumatic brain injury; Veterans; War-Related Injuries - epidemiology; War-Related Injuries - genetics; War-Related Injuries - metabolism; War-Related Injuries - pathology; New York; United States > US; Tau; Chronic traumatic encephalopathy; Alzheimer’s disease; Neurodegenerative disorders; Beta-amyloid; Dementia

Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with repetitive mild traumatic brain injury. It is defined pathologically by the abnormal accumulation of tau in a unique pattern that is distinct from other tauopathies, including Alzheimer’s disease (AD). Although tra...