Absence of mutations in exon 6 of the TARDBP gene in 207 Chinese patients with sporadic amyotrohic lateral sclerosis

• Published in: PloS one Vol. 8; no. 7; p. e68106
• Main Authors: Ye, Cheng-hui, Lu, Xi-lin, Zheng, Min-ying, Zhen, Jun, Li, Zhi-Ping, Shi, Lei, Liu, Zhi-yong, Feng, Lu-yang, Pei, Zhong, Yao, Xiao-li
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 09.07.2013; Public Library of Science (PLoS)
• Subjects: Adult; Amyotrophic lateral sclerosis; Amyotrophic Lateral Sclerosis - genetics; Asian Continental Ancestry Group - genetics; Biology; China; DNA-Binding Proteins - genetics; Exons; Female; Genetic aspects; Genetic Association Studies; Humans; Male; Medical research; Medicine; Middle Aged; Mutation; Protein binding; China

Mutations in the TARDBP gene, which encodes the Tar DNA binding protein, have been shown to causes of both familial amyotrophic lateral sclerosis (FALS) and sporadic ALS (SALS). Recently, several novel TARDBP exon 6 mutants have been reported in patients with ALS in Europe and America but not in Asi...