Highly-sensitive detection of Salmonella typhi in clinical blood samples by magnetic nanoparticle-based enrichment and in-situ measurement of isothermal amplification of nucleic acids

• Published in: PloS one Vol. 13; no. 3; p. e0194817
• Main Authors: Kaur, Avinash, Kapil, Arti, Elangovan, Ravikrishnan, Jha, Sandeep, Kalyanasundaram, Dinesh
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 28.03.2018; Public Library of Science (PLoS)
• Subjects: Analysis; Biology and Life Sciences; Engineering and Technology; Gene amplification; Medicine and Health Sciences; Nucleic acids; Research and Analysis Methods; Salmonella typhi

Enteric fever continues to be a major cause of mortality and morbidity globally, particularly in poor resource settings. Lack of rapid diagnostic assays is a major driving factor for the empirical treatment of enteric fever. In this work, a rapid and sensitive method 'Miod' 'has been...