High-dose antidepressants affect near-infrared spectroscopy signals: A retrospective study

• Published in: NeuroImage clinical Vol. 14; no. C; pp. 648 - 655
• Main Authors: Takamiya, Akihiro, Hirano, Jinichi, Ebuchi, Yuki, Ogino, Satoyuki, Shimegi, Kenichi, Emura, Hiroyuki, Yonemori, Kyoko, Shimazawa, Akiko, Miura, Gentaro, Hyodo, Ayako, Hyodo, Sari, Nagai, Tunetaka, Funaki, Madoka, Sugihara, Masako, Kita, Mitsuhiro, Yamagata, Bun, Mimura, Masaru
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.01.2017; Elsevier
• Subjects: Adult; Antidepressant; Antidepressive Agents - therapeutic use; Bipolar disorder; Cognition Disorders - etiology; Dose-Response Relationship, Drug; Female; Humans; Magnetic Resonance Imaging; Major depressive disorder (MDD); Male; Middle Aged; Mood Disorders - complications; Mood Disorders - diagnostic imaging; Mood Disorders - drug therapy; Near-infrared spectroscopy (NIRS); Nerve Net - diagnostic imaging; Nerve Net - drug effects; Nerve Net - metabolism; Oxyhemoglobins - metabolism; Parietal Lobe - diagnostic imaging; Parietal Lobe - drug effects; Parietal Lobe - metabolism; Psychiatric Status Rating Scales; Radiology; Regression Analysis; Regular; Retrospective Studies; Schizophrenia; Spectroscopy, Near-Infrared; Temporal Lobe - diagnostic imaging; Temporal Lobe - drug effects; Temporal Lobe - metabolism; Antidepressant; International Classification of Diseases; Diagnostic and Statistical Manual of Mental Disorders; magnetic resonance imaging; near-infrared spectroscopy; World Health Organization; Anatomical Therapeutic Chemical; defined daily dose; Schizophrenia; Bipolar disorder; Near-infrared spectroscopy (NIRS); oxy-hemoglobin; regional cerebral blood volume; major depressive disorder; verbal fluency task; Major depressive disorder (MDD); Montgomery Asberg Depression Rating Scale; positron emission tomography; Hamilton Rating Scale for Depression-17 item; DDD; MRI; HRSD-17; MDD; rCBV; NIRS; DSM; WHO; VFT; MADRS; ICD; oxy-Hb; ATC; PET; Hamilton Rating Scale for Depression-17 item, (HRSD-17); International Classification of Diseases, (ICD); World Health Organization, (WHO); Anatomical Therapeutic Chemical, (ATC); magnetic resonance imaging, (MRI); major depressive disorder, (MDD); verbal fluency task, (VFT); near-infrared spectroscopy, (NIRS); positron emission tomography, (PET); defined daily dose, (DDD); regional cerebral blood volume, (rCBV); Diagnostic and Statistical Manual of Mental Disorders, (DSM); oxy-hemoglobin, (oxy-Hb); Montgomery Asberg Depression Rating Scale, (MADRS)

Recent studies have highlighted the clinical usefulness of near-infrared spectroscopy (NIRS) in psychiatry. However, the potential effects of psychotropics on NIRS signals remain unknown. We conducted a systematic chart review of 40 depressed patients who underwent NIRS scans during a verbal fluency...