Genome-wide association study of therapeutic opioid dosing identifies a novel locus upstream of OPRM1 - Smith, A H; Jensen, K P; Li, J; Nunez, Y; Farrer, L A; Hakonarson, H; Cook-Sather, S D; Kranzler, H R; Gelernter, J (Molecular psychiatry, 2017)
Keywords: 692/53/2423; Addictions; Adult; African Americans; Alleles; Analgesics; Analgesics, Opioid - administration & dosage; Analgesics, Opioid - pharmacology; Analgesics, Opioid - therapeutic use; Behavioral Sciences; Biological Psychology; Black or African American - genetics; Dosage; Dose-response relationship; Dose-Response Relationship, Drug; Drug dependence; Drug dosages; Drug therapy; Female; Gene Frequency; Gene loci; Genetic aspects; Genetic diversity; Genetic Predisposition to Disease - genetics; Genetic variation; Genetics; Genome-wide association studies; Genome-Wide Association Study - methods; Genomes; Genotype; Health aspects; Humans; immediate-communication; Male; Medicine; Medicine & Public Health; Methadone; Methadone - therapeutic use; Middle Aged; Morphine; Morphine - therapeutic use; Narcotics; Neurosciences; Opioid receptors; Opioid-Related Disorders - genetics; Opium habit; Pain; Pain - drug therapy; Pain - genetics; Pharmacotherapy; Polymorphism, Single Nucleotide - genetics; Psychiatry; Public health; Receptors, Opioid, mu - genetics; Risk factors; United States; White People - genetics; United States; United States--US