Population pharmacokinetics of daptomycin in critically ill patients

• Published in: International journal of antimicrobial agents Vol. 52; no. 2; pp. 158 - 165
• Main Authors: Soraluce, A., Asín-Prieto, E., Rodríguez-Gascón, A., Barrasa, H., Maynar, J., Carcelero, E., Soy, D., Isla, A.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.08.2018
• Subjects: Acute Kidney Injury - pathology; Acute Kidney Injury - therapy; Aged; Aged, 80 and over; Anti-Bacterial Agents - blood; Anti-Bacterial Agents - pharmacokinetics; Area Under Curve; blood; Continuous renal replacement therapies; creatinine; Creatinine - blood; Critical Illness; Critically ill; Daptomycin; Daptomycin - blood; Daptomycin - pharmacokinetics; data analysis; Drug Administration Schedule; Drug Dosage Calculations; Female; Gram-positive bacteria; Humans; Infectious Disease; Intensive Care Units; Male; Microbial Sensitivity Tests; Middle Aged; minimum inhibitory concentration; Monte Carlo Method; patients; pharmacodynamics; Pharmacokinetic/pharmacodynamic analysis; Pharmacokinetics; Prospective Studies; Renal Dialysis - instrumentation; Renal Dialysis - methods; therapeutics; toxicity; Pharmacokinetics; Critically ill; Continuous renal replacement therapies; Daptomycin; Pharmacokinetic/pharmacodynamic analysis

•A population PK model for daptomycin in critically ill patients was performed.•Daptomycin clearance depended on creatinine clearance and extracorporeal clearance.•PK/PD analysis showed that with the approved dosages, patients are often underdosed.•Dosage should consider renal function and the use o...