Eutherian mammals use diverse strategies to initiate X-chromosome inactivation during development

• Published in: Nature (London) Vol. 472; no. 7343; pp. 370 - 374
• Main Authors: Okamoto, Ikuhiro, Patrat, Catherine, Thépot, Dominique, Peynot, Nathalie, Fauque, Patricia, Daniel, Nathalie, Diabangouaya, Patricia, Wolf, Jean-Philippe, Renard, Jean-Paul, Duranthon, Véronique, Heard, Edith
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 21.04.2011; Nature Publishing Group
• Subjects: 631/136/2086; 631/208/182; 631/337/176/1433; Animal development; Animals; Biological and medical sciences; Biological Evolution; Blastocyst - metabolism; Cell physiology; Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes; Chromosomes; Chromosomes, Mammalian - genetics; Compensation; Development Biology; Dosage Compensation, Genetic - genetics; Embryo, Mammalian - embryology; Embryo, Mammalian - metabolism; Embryonic growth stage; Eutherians; Female; Females; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation, Developmental - genetics; Genes, X-Linked - genetics; Genetic aspects; Genetic engineering; Genomic Imprinting - genetics; Histones - metabolism; Humanities and Social Sciences; Humans; Hypoxanthine Phosphoribosyltransferase - genetics; Inactivation; letter; Life Sciences; Male; Males; Mammals; Mammals - embryology; Mammals - genetics; Mice; Molecular and cellular biology; multidisciplinary; Observations; Parthenogenesis; Physiological aspects; Rabbits; Reproductive Biology; RNA, Long Noncoding; RNA, Untranslated - genetics; Science; Science (multidisciplinary); Species Specificity; Up-Regulation - genetics; X Chromosome - genetics; X chromosome inactivation; X Chromosome Inactivation - genetics; France; Development; Strategy; Vertebrata; Mammalia; X-Chromosome; Inactivation

Mice out of step on X inactivation X-chromosome inactivation is an essential process in female mammals that compensates for the presence of two X-chromosomes by suppressing gene expression from one of them. A study of the early developmental time course of X-chromosome inactivation in mice, rabbits...