Eutherian mammals use diverse strategies to initiate X-chromosome inactivation during development
Mice out of step on X inactivation X-chromosome inactivation is an essential process in female mammals that compensates for the presence of two X-chromosomes by suppressing gene expression from one of them. A study of the early developmental time course of X-chromosome inactivation in mice, rabbits...
Saved in:
| Published in | Nature (London) Vol. 472; no. 7343; pp. 370 - 374 |
|---|---|
| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
21.04.2011
Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Mice out of step on X inactivation
X-chromosome inactivation is an essential process in female mammals that compensates for the presence of two X-chromosomes by suppressing gene expression from one of them. A study of the early developmental time course of X-chromosome inactivation in mice, rabbits and humans shows that the processes in mice, in which most of previous analyses have been done, differ significantly from those in other eutherian species. The study highlights a diversity in X-inactivation regulation that may reflect the changing nature of developmental processes during evolution.
X-chromosome inactivation (XCI) in female mammals allows dosage compensation for X-linked gene products between the sexes
1
. The developmental regulation of this process has been extensively investigated in mice, where the X chromosome of paternal origin (Xp) is silenced during early embryogenesis owing to imprinted expression of the regulatory RNA,
Xist
(X-inactive specific transcript). Paternal XCI is reversed in the inner cell mass of the blastocyst and random XCI subsequently occurs in epiblast cells. Here we show that other eutherian mammals have very different strategies for initiating XCI. In rabbits and humans, the
Xist
homologue is not subject to imprinting and XCI begins later than in mice. Furthermore,
Xist
is upregulated on both X chromosomes in a high proportion of rabbit and human embryo cells, even in the inner cell mass. In rabbits, this triggers XCI on both X chromosomes in some cells. In humans, chromosome-wide XCI has not initiated even by the blastocyst stage, despite the upregulation of
XIST
. The choice of which X chromosome will finally become inactive thus occurs downstream of
Xist
upregulation in both rabbits and humans, unlike in mice. Our study demonstrates the remarkable diversity in XCI regulation and highlights differences between mammals in their requirement for dosage compensation during early embryogenesis. |
|---|---|
| AbstractList | X-chromosome inactivation (XCI) in female mammals allows dosage compensation for X-linked gene products between the sexes. The developmental regulation of this process has been extensively investigated in mice, where the X chromosome of paternal origin (Xp) is silenced during early embryogenesis owing to imprinted expression of the regulatory RNA, Xist (X-inactive specific transcript). Paternal XCI is reversed in the inner cell mass of the blastocyst and random XCI subsequently occurs in epiblast cells. Here we show that other eutherian mammals have very different strategies for initiating XCI. In rabbits and humans, the Xist homologue is not subject to imprinting and XCI begins later than in mice. Furthermore, Xist is upregulated on both X chromosomes in a high proportion of rabbit and human embryo cells, even in the inner cell mass. In rabbits, this triggers XCI on both X chromosomes in some cells. In humans, chromosome-wide XCI has not initiated even by the blastocyst stage, despite the upregulation of XIST. The choice of which X chromosome will finally become inactive thus occurs downstream of Xist upregulation in both rabbits and humans, unlike in mice. Our study demonstrates the remarkable diversity in XCI regulation and highlights differences between mammals in their requirement for dosage compensation during early embryogenesis.X-chromosome inactivation (XCI) in female mammals allows dosage compensation for X-linked gene products between the sexes. The developmental regulation of this process has been extensively investigated in mice, where the X chromosome of paternal origin (Xp) is silenced during early embryogenesis owing to imprinted expression of the regulatory RNA, Xist (X-inactive specific transcript). Paternal XCI is reversed in the inner cell mass of the blastocyst and random XCI subsequently occurs in epiblast cells. Here we show that other eutherian mammals have very different strategies for initiating XCI. In rabbits and humans, the Xist homologue is not subject to imprinting and XCI begins later than in mice. Furthermore, Xist is upregulated on both X chromosomes in a high proportion of rabbit and human embryo cells, even in the inner cell mass. In rabbits, this triggers XCI on both X chromosomes in some cells. In humans, chromosome-wide XCI has not initiated even by the blastocyst stage, despite the upregulation of XIST. The choice of which X chromosome will finally become inactive thus occurs downstream of Xist upregulation in both rabbits and humans, unlike in mice. Our study demonstrates the remarkable diversity in XCI regulation and highlights differences between mammals in their requirement for dosage compensation during early embryogenesis. X-chromosome inactivation (XCI) in female mammals allows dosage compensation for X-linked gene products between the sexes. The developmental regulation of this process has been extensively investigated in mice, where the X chromosome of paternal origin (Xp) is silenced during early embryogenesis owing to imprinted expression of the regulatory RNA, Xist (X-inactive specific transcript). Paternal XCI is reversed in the inner cell mass of the blastocyst and random XCI subsequently occurs in epiblast cells. Here we show that other eutherian mammals have very different strategies for initiating XCI. In rabbits and humans, the Xist homologue is not subject to imprinting and XCI begins later than in mice. Furthermore, Xist is upregulated on both X chromosomes in a high proportion of rabbit and human embryo cells, even in the inner cell mass. In rabbits, this triggers XCI on both X chromosomes in some cells. In humans, chromosome-wide XCI has not initiated even by the blastocyst stage, despite the upregulation of XIST. The choice of which X chromosome will finally become inactive thus occurs downstream of Xist upregulation in both rabbits and humans, unlike in mice. Our study demonstrates the remarkable diversity in XCI regulation and highlights differences between mammals in their requirement for dosage compensation during early embryogenesis. Mice out of step on X inactivation X-chromosome inactivation is an essential process in female mammals that compensates for the presence of two X-chromosomes by suppressing gene expression from one of them. A study of the early developmental time course of X-chromosome inactivation in mice, rabbits and humans shows that the processes in mice, in which most of previous analyses have been done, differ significantly from those in other eutherian species. The study highlights a diversity in X-inactivation regulation that may reflect the changing nature of developmental processes during evolution. X-chromosome inactivation (XCI) in female mammals allows dosage compensation for X-linked gene products between the sexes 1 . The developmental regulation of this process has been extensively investigated in mice, where the X chromosome of paternal origin (Xp) is silenced during early embryogenesis owing to imprinted expression of the regulatory RNA, Xist (X-inactive specific transcript). Paternal XCI is reversed in the inner cell mass of the blastocyst and random XCI subsequently occurs in epiblast cells. Here we show that other eutherian mammals have very different strategies for initiating XCI. In rabbits and humans, the Xist homologue is not subject to imprinting and XCI begins later than in mice. Furthermore, Xist is upregulated on both X chromosomes in a high proportion of rabbit and human embryo cells, even in the inner cell mass. In rabbits, this triggers XCI on both X chromosomes in some cells. In humans, chromosome-wide XCI has not initiated even by the blastocyst stage, despite the upregulation of XIST . The choice of which X chromosome will finally become inactive thus occurs downstream of Xist upregulation in both rabbits and humans, unlike in mice. Our study demonstrates the remarkable diversity in XCI regulation and highlights differences between mammals in their requirement for dosage compensation during early embryogenesis. Mice out of step on X inactivation X-chromosome inactivation (XCI) in female mammals allows dosage compensation for X-linked gene products between the sexes1. The developmental regulation of this process has been extensively investigated in mice, where the X chromosome of paternal origin (Xp) is silenced during early embryogenesis owing to imprinted expression of the regulatory RNA, Xist (X-inactive specific transcript). Paternal XCI is reversed in the inner cell mass of the blastocyst and random XCI subsequently occurs in epiblast cells. Here we show that other eutherian mammals have very different strategies for initiating XCI. In rabbits and humans, the Xist homologue is not subject to imprinting and XCI begins later than in mice. Furthermore,Xist is upregulated on both X chromosomes in a high proportion of rabbit andhuman embryo cells, even in the inner cell mass. In rabbits, this triggers XCI on both X chromosomes in some cells. In humans, chromosome-wide XCI has not initiated even by the blastocyst stage, despite the upregulation of XIST. The choice of which X chromosome will finally become inactive thus occurs downstream of Xist upregulation in both rabbits and humans, unlike in mice. Our study demonstrates the remarkable diversity in XCI regulation and highlights differences between mammals in their requirement for dosage compensation during early embryogenesis. X-chromosome inactivation (XCI) in female mammals allows dosage compensation for X-linked gene products between the sexes. The developmental regulation of this process has been extensively investigated in mice, where the X chromosome of paternal origin (Xp) is silenced during early embryogenesis owing to imprinted expression of the regulatory RNA, Xist (X-inactive specific transcript). Paternal XCI is reversed in the inner cell mass of the blastocyst and random XCI subsequently occurs in epiblast cells. Here we show that other eutherian mammals have very different strategies for initiating XCI. In rabbits and humans, the Xist homologue is not subject to imprinting and XCI begins later than in mice. Furthermore, Xist is upregulated on both X chromosomes in a high proportion of rabbit and human embryo cells, even in the inner cell mass. In rabbits, this triggers XCI on both X chromosomes in some cells. In humans, chromosome-wide XCI has not initiated even by the blastocyst stage, despite the upregulation of XIST. The choice of which X chromosome will finally become inactive thus occurs downstream of Xist upregulation in both rabbits and humans, unlike in mice. Our study demonstrates the remarkable diversity in XCI regulation and highlights differences between mammals in their requirement for dosage compensation during early embryogenesis. [PUBLICATION ABSTRACT] |
| Audience | Academic |
| Author | Renard, Jean-Paul Thépot, Dominique Duranthon, Véronique Okamoto, Ikuhiro Heard, Edith Fauque, Patricia Peynot, Nathalie Daniel, Nathalie Diabangouaya, Patricia Wolf, Jean-Philippe Patrat, Catherine |
| Author_xml | – sequence: 1 givenname: Ikuhiro surname: Okamoto fullname: Okamoto, Ikuhiro organization: Mammalian Developmental Epigenetics Group, Institut Curie, CNRS UMR 3215, INSERM U934 – sequence: 2 givenname: Catherine surname: Patrat fullname: Patrat, Catherine organization: Mammalian Developmental Epigenetics Group, Institut Curie, CNRS UMR 3215, INSERM U934, Université Paris Diderot – Assistance Publique Hôpitaux de Paris – Service de Biologie de la Reproduction, Hôpital Bichat-Claude Bernard – sequence: 3 givenname: Dominique surname: Thépot fullname: Thépot, Dominique organization: INRA UMR 1198 Biologie du Développement et de la Reproduction – sequence: 4 givenname: Nathalie surname: Peynot fullname: Peynot, Nathalie organization: INRA UMR 1198 Biologie du Développement et de la Reproduction – sequence: 5 givenname: Patricia surname: Fauque fullname: Fauque, Patricia organization: Laboratoire de Biologie de la reproduction CECOS, CHU de Dijon, Université de Bourgogne, Epigenetic Decisions and Reproduction in mammals, Institut Curie, CNRS UMR 3215, INSERM U934 – sequence: 6 givenname: Nathalie surname: Daniel fullname: Daniel, Nathalie organization: INRA UMR 1198 Biologie du Développement et de la Reproduction – sequence: 7 givenname: Patricia surname: Diabangouaya fullname: Diabangouaya, Patricia organization: Mammalian Developmental Epigenetics Group, Institut Curie, CNRS UMR 3215, INSERM U934 – sequence: 8 givenname: Jean-Philippe surname: Wolf fullname: Wolf, Jean-Philippe organization: Unité Inserm 1016, Université Paris Descartes – Assistance Publique Hôpitaux de Paris – Service de Biologie de la Reproduction, Hôpital Cochin – sequence: 9 givenname: Jean-Paul surname: Renard fullname: Renard, Jean-Paul organization: INRA UMR 1198 Biologie du Développement et de la Reproduction – sequence: 10 givenname: Véronique surname: Duranthon fullname: Duranthon, Véronique email: veronique.duranthon@jouy.inra.fr organization: INRA UMR 1198 Biologie du Développement et de la Reproduction – sequence: 11 givenname: Edith surname: Heard fullname: Heard, Edith email: edith.heard@curie.fr organization: Mammalian Developmental Epigenetics Group, Institut Curie, CNRS UMR 3215, INSERM U934 |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24070021$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/21471966$$D View this record in MEDLINE/PubMed https://hal.science/hal-01019321$$DView record in HAL |
| BookMark | eNqF0u9r1DAYB_AiE3ebvvK9FIfI0GrS5vLj5TGmGxwI_gDfhTR9epfRJl2SHvrfm3rnbjcUX4WGT54-efI9yY6ss5BlzzF6h1HF31sVRw9IcFY-ymaYMFoQytlRNkOo5AXiFT3OTkK4QQjNMSNPsuMyKSwonWXqcoxr8EbZvFd9r7qQjwHyxmzApzVEryKsDIQ8utxYE036zr8Xeu1d74LrIe0qHc1GReNs3oze2FXewAY6N_Rg49PscZvKwrPdepp9-3D59eKqWH76eH2xWBaaEhSLipQcWq3nc1Y3lWLzmqAWU8Gp0IyTUpe81aLWQmE0b5limDFBQFPdoLaGujrNzrd116qTgze98j-lU0ZeLZZy2kMYYVGVeIOTfb21g3e3I4QoexM0dJ2y4MYgBSqrilPE_is5TY1TQsokXz6QN270Nl05IcKx4OX047MtWqkOpLGtSwPWU0m5oFVJBEmvuC91oPRgbuV9dH6AtLMRfsSVGkOQ118-HxZ8settrHto7sbzJwcJvNoBFbTqWq-sNmHvCGIpTFP_b7ZOexeCh_aOYCSnNMp7aUwaP9DaxN85Sfcx3T_OvN2eCcOUJPD7Mf6N_wIXq-8R |
| CODEN | NATUAS |
| CitedBy_id | crossref_primary_10_1038_ncomms8095 crossref_primary_10_1186_s12915_024_01994_y crossref_primary_10_1186_s40246_022_00410_2 crossref_primary_10_1016_j_stem_2017_02_014 crossref_primary_10_1530_REP_17_0466 crossref_primary_10_1002_bies_201700239 crossref_primary_10_1007_s43032_021_00780_3 crossref_primary_10_1016_j_cell_2023_11_033 crossref_primary_10_1016_j_scr_2017_01_008 crossref_primary_10_1093_genetics_iyab043 crossref_primary_10_1093_molehr_gau027 crossref_primary_10_1111_cpr_13468 crossref_primary_10_1146_annurev_genet_110711_155454 crossref_primary_10_1089_scd_2011_0685 crossref_primary_10_1182_blood_2011_11_390351 crossref_primary_10_1007_s00439_011_1014_9 crossref_primary_10_1101_gad_318675_118 crossref_primary_10_1007_s12015_015_9597_5 crossref_primary_10_1038_s41467_017_02107_w crossref_primary_10_1073_pnas_1900065116 crossref_primary_10_1038_s41598_021_89175_7 crossref_primary_10_1159_000492188 crossref_primary_10_1038_nature12745 crossref_primary_10_1016_j_celrep_2023_112379 crossref_primary_10_1126_sciadv_adg1936 crossref_primary_10_1038_s41556_018_0089_0 crossref_primary_10_1016_j_stem_2020_05_014 crossref_primary_10_1007_s00018_012_1174_3 crossref_primary_10_1152_physrev_00001_2014 crossref_primary_10_1051_medsci_2020278 crossref_primary_10_1016_j_cell_2013_02_043 crossref_primary_10_1038_s42003_025_07691_y crossref_primary_10_1371_journal_pcbi_1002229 crossref_primary_10_1016_j_molcel_2018_03_024 crossref_primary_10_1146_annurev_cellbio_101512_122415 crossref_primary_10_7554_eLife_19127 crossref_primary_10_1016_j_gde_2023_102096 crossref_primary_10_1186_s12859_019_3141_6 crossref_primary_10_3389_fcell_2019_00169 crossref_primary_10_1242_dev_142778 crossref_primary_10_1002_term_1779 crossref_primary_10_1007_s12015_014_9505_4 crossref_primary_10_1016_j_cell_2016_03_023 crossref_primary_10_1038_ncomms12354 crossref_primary_10_1038_s41598_017_11044_z crossref_primary_10_1016_j_ceb_2012_02_004 crossref_primary_10_1042_BST20170346 crossref_primary_10_1016_j_celrep_2019_03_019 crossref_primary_10_3389_fcell_2017_00063 crossref_primary_10_1016_j_semcdb_2016_01_044 crossref_primary_10_1038_nrg2987 crossref_primary_10_1016_j_devcel_2016_06_014 crossref_primary_10_1186_s13072_021_00386_8 crossref_primary_10_1016_j_stem_2019_06_010 crossref_primary_10_1186_s13048_024_01555_5 crossref_primary_10_3390_epigenomes7040028 crossref_primary_10_1101_cshperspect_a039677 crossref_primary_10_3168_jds_2020_19497 crossref_primary_10_1038_s41588_018_0305_7 crossref_primary_10_1038_nrg_2015_2 crossref_primary_10_1038_nrm3231 crossref_primary_10_1038_s41431_022_01115_9 crossref_primary_10_1007_s00439_011_1038_1 crossref_primary_10_1530_REP_10_0380 crossref_primary_10_1007_s00429_012_0463_9 crossref_primary_10_1186_s13287_017_0657_4 crossref_primary_10_3934_biophy_2021026 crossref_primary_10_1111_brv_12117 crossref_primary_10_1016_j_cell_2015_05_012 crossref_primary_10_1016_j_fertnstert_2014_03_010 crossref_primary_10_1038_nature13804 crossref_primary_10_1016_j_ydbio_2012_08_009 crossref_primary_10_1093_hmg_ddr506 crossref_primary_10_3390_biom4010076 crossref_primary_10_1016_j_yexcr_2019_111645 crossref_primary_10_1038_s41556_023_01266_x crossref_primary_10_1002_mrd_22970 crossref_primary_10_1051_medsci_2013292024 crossref_primary_10_1093_hmg_ddac285 crossref_primary_10_1016_j_stem_2015_03_016 crossref_primary_10_1262_jrd_2015_017 crossref_primary_10_1038_s41598_019_38807_0 crossref_primary_10_1073_pnas_1523538113 crossref_primary_10_1093_humrep_des072 crossref_primary_10_1016_j_semcdb_2016_01_024 crossref_primary_10_1038_srep14101 crossref_primary_10_1098_rstb_2016_0358 crossref_primary_10_1152_ajpcell_00318_2021 crossref_primary_10_1016_j_gde_2023_102063 crossref_primary_10_1098_rstb_2016_0355 crossref_primary_10_1016_j_gde_2018_04_005 crossref_primary_10_1038_s41556_020_00607_4 crossref_primary_10_1002_bies_201900163 crossref_primary_10_1111_hae_14186 crossref_primary_10_1016_j_semcdb_2022_02_010 crossref_primary_10_1007_s00109_022_02227_x crossref_primary_10_1093_lifemedi_lnad006 crossref_primary_10_1371_journal_pone_0051398 crossref_primary_10_1016_j_tig_2017_09_005 crossref_primary_10_1093_gbe_evy270 crossref_primary_10_1016_j_stemcr_2014_04_003 crossref_primary_10_1016_j_fmre_2022_08_011 crossref_primary_10_1007_s00412_017_0650_9 crossref_primary_10_1016_j_gde_2024_102235 crossref_primary_10_1098_rstb_2012_0292 crossref_primary_10_1016_S0001_4079_19_31558_4 crossref_primary_10_1242_dev_183095 crossref_primary_10_1007_s00018_019_03123_3 crossref_primary_10_1016_j_bbrc_2023_01_077 crossref_primary_10_1186_s12864_015_1506_4 crossref_primary_10_1101_gr_135046_111 crossref_primary_10_1186_s13059_024_03286_8 crossref_primary_10_1016_j_stem_2020_06_002 crossref_primary_10_1186_s40246_018_0185_z crossref_primary_10_1146_annurev_cellbio_022020_024900 crossref_primary_10_1242_dev_146811 crossref_primary_10_1097_ICO_0000000000002017 crossref_primary_10_1016_j_fertnstert_2015_12_013 crossref_primary_10_1002_stem_3064 crossref_primary_10_1042_BST20230416 crossref_primary_10_4161_rna_29779 crossref_primary_10_1080_15592294_2019_1600828 crossref_primary_10_1016_j_mod_2015_10_005 crossref_primary_10_1007_s12041_015_0566_1 crossref_primary_10_1016_j_anireprosci_2012_08_010 crossref_primary_10_3389_fcell_2016_00134 crossref_primary_10_1007_s00439_011_1024_7 crossref_primary_10_1242_dev_202891 crossref_primary_10_1016_j_cell_2023_04_020 crossref_primary_10_1016_j_semcdb_2016_01_006 crossref_primary_10_1007_s10577_011_9255_y crossref_primary_10_1016_j_ceb_2012_10_007 crossref_primary_10_1089_scd_2013_0368 crossref_primary_10_1186_s12864_016_3466_8 crossref_primary_10_1530_REP_12_0259 crossref_primary_10_1038_nmeth_2534 crossref_primary_10_1093_humrep_dew214 crossref_primary_10_1186_s12862_014_0267_z crossref_primary_10_3389_fcell_2022_940197 crossref_primary_10_1016_j_stem_2012_06_012 crossref_primary_10_3389_fcell_2021_637309 crossref_primary_10_1017_S2040174423000260 crossref_primary_10_1080_15476286_2020_1725725 crossref_primary_10_1126_science_abd8887 crossref_primary_10_1242_dev_071688 crossref_primary_10_1007_s12035_023_03740_x crossref_primary_10_1016_j_gde_2022_101927 crossref_primary_10_1016_j_gde_2013_01_008 crossref_primary_10_1186_s12863_014_0089_4 crossref_primary_10_15252_embj_2022112962 crossref_primary_10_1016_j_cub_2018_09_018 crossref_primary_10_1146_annurev_cellbio_092910_154020 crossref_primary_10_1016_j_devcel_2017_04_019 crossref_primary_10_1128_MCB_00382_20 crossref_primary_10_1016_j_stem_2016_10_006 crossref_primary_10_1016_j_celrep_2016_11_054 crossref_primary_10_1101_gr_183301_114 crossref_primary_10_1242_dev_152041 crossref_primary_10_1007_s00412_011_0343_8 crossref_primary_10_1016_j_cub_2022_09_027 crossref_primary_10_1371_journal_pgen_1003635 crossref_primary_10_3934_genet_2015_2_110 crossref_primary_10_1146_annurev_genet_120116_024611 crossref_primary_10_1038_s41586_020_2629_6 crossref_primary_10_1007_s13770_017_0096_4 crossref_primary_10_1007_s00439_011_1029_2 crossref_primary_10_1042_BCJ20220450 crossref_primary_10_1073_pnas_1319738111 crossref_primary_10_1371_journal_pone_0088256 crossref_primary_10_1016_j_gendis_2022_04_007 crossref_primary_10_1016_j_stemcr_2020_03_027 crossref_primary_10_1016_j_scr_2017_11_017 crossref_primary_10_1038_s41594_019_0214_1 crossref_primary_10_1242_dev_202993 crossref_primary_10_1186_2045_3701_4_74 crossref_primary_10_1242_dev_116061 crossref_primary_10_1016_j_stem_2016_10_014 crossref_primary_10_1002_dvg_20792 crossref_primary_10_1093_humupd_dmx015 crossref_primary_10_1186_2042_6410_4_5 crossref_primary_10_1080_13102818_2014_907037 crossref_primary_10_1016_j_jmb_2017_03_013 crossref_primary_10_4161_rna_25802 crossref_primary_10_3390_cells11030535 crossref_primary_10_1002_humu_22013 crossref_primary_10_1016_j_ijbiomac_2022_12_221 crossref_primary_10_1038_s41576_020_0245_9 crossref_primary_10_1016_j_tig_2016_03_001 crossref_primary_10_1016_j_yexcr_2020_111908 crossref_primary_10_1016_j_stem_2023_09_010 crossref_primary_10_1007_s00439_011_1011_z crossref_primary_10_1016_j_isci_2022_105469 crossref_primary_10_1038_nrg3687 crossref_primary_10_1007_s12041_015_0574_1 crossref_primary_10_1038_nbt_2139 crossref_primary_10_3390_cells9041016 crossref_primary_10_1016_j_gde_2012_03_001 crossref_primary_10_1186_1756_8935_6_23 crossref_primary_10_1007_s00018_013_1499_6 crossref_primary_10_1073_pnas_2412185121 crossref_primary_10_1002_bies_201800024 crossref_primary_10_1101_gr_161919_113 crossref_primary_10_1038_nrg_2017_17 crossref_primary_10_1038_s41594_024_01325_3 crossref_primary_10_3389_fgene_2017_00042 crossref_primary_10_1371_journal_pone_0083458 crossref_primary_10_3390_jdb9020015 crossref_primary_10_1016_j_stem_2018_06_018 crossref_primary_10_1038_ncomms5878 crossref_primary_10_1038_s41586_024_07351_x crossref_primary_10_1242_dev_145177 crossref_primary_10_1002_bies_201600121 crossref_primary_10_1038_s41598_017_17017_6 crossref_primary_10_1093_jmcb_mjy082 crossref_primary_10_1051_medsci_2012285018 crossref_primary_10_1126_sciadv_adf2245 crossref_primary_10_1007_s12015_019_9871_z crossref_primary_10_1101_gad_349390_122 crossref_primary_10_1038_s41556_018_0123_2 crossref_primary_10_1038_cr_2017_25 crossref_primary_10_15252_embr_201846294 crossref_primary_10_1002_wrna_1359 crossref_primary_10_1038_s41467_022_30259_x crossref_primary_10_1038_s41598_019_42246_2 crossref_primary_10_1186_s13072_022_00458_3 crossref_primary_10_1016_j_ceb_2024_102446 crossref_primary_10_1038_srep16023 crossref_primary_10_1007_s12522_014_0184_2 crossref_primary_10_1016_j_cell_2014_08_029 crossref_primary_10_1146_annurev_genom_091212_153530 crossref_primary_10_1016_j_rbmo_2021_03_010 crossref_primary_10_1098_rstb_2016_0366 crossref_primary_10_1098_rstb_2016_0365 crossref_primary_10_1073_pnas_1116763109 crossref_primary_10_1242_dev_069328 crossref_primary_10_3390_app10248861 crossref_primary_10_1186_s12864_018_5233_5 crossref_primary_10_1007_s11248_012_9599_x crossref_primary_10_1002_stem_1992 crossref_primary_10_1098_rstb_2016_0363 crossref_primary_10_1371_journal_pone_0073677 crossref_primary_10_1371_journal_pone_0055345 crossref_primary_10_1089_scd_2014_0011 crossref_primary_10_3390_toxics11050425 crossref_primary_10_1002_stem_755 crossref_primary_10_1016_j_brainresbull_2011_06_018 crossref_primary_10_1080_19491034_2020_1850981 crossref_primary_10_1016_j_celrep_2021_109215 crossref_primary_10_1038_s41580_021_00438_7 crossref_primary_10_1016_j_stemcr_2017_12_015 crossref_primary_10_1016_j_theriogenology_2024_01_009 crossref_primary_10_1007_s00439_011_1016_7 crossref_primary_10_1007_s10577_023_09717_9 crossref_primary_10_1007_s00412_019_00717_5 crossref_primary_10_1016_j_cell_2013_02_016 crossref_primary_10_1016_j_yexcr_2012_11_009 crossref_primary_10_7554_eLife_44258 crossref_primary_10_1242_dev_201741 crossref_primary_10_4236_abb_2014_56067 crossref_primary_10_1016_j_semcdb_2016_04_002 crossref_primary_10_1016_j_stem_2012_05_019 crossref_primary_10_1186_s13059_021_02518_5 crossref_primary_10_1016_j_biocel_2017_05_029 crossref_primary_10_1242_dev_065276 crossref_primary_10_1016_j_febslet_2014_06_023 crossref_primary_10_1242_dev_200538 crossref_primary_10_1007_s00018_017_2703_x crossref_primary_10_1038_ng_2530 crossref_primary_10_1186_gb_2012_13_8_r70 crossref_primary_10_1016_j_gde_2017_06_009 crossref_primary_10_1371_journal_pgen_1002212 crossref_primary_10_1016_j_tcb_2018_05_005 crossref_primary_10_1007_s10577_022_09706_4 crossref_primary_10_1093_humupd_dmx042 crossref_primary_10_1371_journal_pgen_1006375 crossref_primary_10_1098_rstb_2020_0124 crossref_primary_10_1038_s41467_018_04215_7 crossref_primary_10_2903_j_efsa_2012_2794 crossref_primary_10_1126_sciadv_adn7724 crossref_primary_10_1016_j_stem_2011_06_004 crossref_primary_10_1038_s41467_024_53449_1 crossref_primary_10_1371_journal_pone_0032701 crossref_primary_10_1186_s13100_019_0151_x crossref_primary_10_1530_REP_12_0091 crossref_primary_10_1146_annurev_animal_022513_114144 crossref_primary_10_1038_nprot_2016_016 crossref_primary_10_1530_REP_17_0689 crossref_primary_10_1530_REP_13_0173 crossref_primary_10_1016_j_stem_2016_06_011 crossref_primary_10_1016_j_stem_2016_12_004 crossref_primary_10_1038_nature10184 crossref_primary_10_1371_journal_pone_0172920 crossref_primary_10_2217_epi_13_80 crossref_primary_10_1038_nature15515 crossref_primary_10_1155_2016_9451492 crossref_primary_10_1101_gr_185926_114 crossref_primary_10_1242_dev_068320 crossref_primary_10_1016_j_celrep_2023_112686 crossref_primary_10_1002_mrd_23573 crossref_primary_10_1186_1756_8935_6_S1_O33 crossref_primary_10_1016_j_stem_2014_07_002 crossref_primary_10_1038_s41580_024_00804_1 crossref_primary_10_1071_RD14309 crossref_primary_10_1242_dev_157404 crossref_primary_10_1016_j_rbmo_2013_07_016 crossref_primary_10_1038_ejhg_2013_84 crossref_primary_10_1016_j_semcdb_2016_04_014 crossref_primary_10_1111_joim_12493 crossref_primary_10_1038_s41467_019_13551_1 crossref_primary_10_1016_j_cell_2016_04_042 crossref_primary_10_1126_science_abm1857 crossref_primary_10_1038_s41467_019_08387_8 crossref_primary_10_1016_j_ceb_2013_03_001 crossref_primary_10_1038_hdy_2011_106 crossref_primary_10_1007_s00018_024_05151_0 crossref_primary_10_1016_j_stem_2024_01_009 |
| Cites_doi | 10.1159/000069807 10.1006/dbio.1994.1188 10.1002/j.1460-2075.1982.tb01230.x 10.1016/j.fertnstert.2009.03.105 10.1038/230231a0 10.1126/science.1126316 10.1016/0012-1606(73)90254-6 10.1007/s10577-009-9057-7 10.1016/S1534-5807(03)00068-6 10.1038/190372a0 10.1186/1471-2199-11-20 10.1016/j.cell.2007.12.036 10.1016/0092-8674(94)90049-3 10.1038/nbt0402-366 10.1016/j.ajhg.2009.05.003 10.1038/256640a0 10.1002/bies.201000019 10.1016/j.gene.2005.11.025 10.1159/000071568 10.1101/gr.9.9.868 10.1126/science.1092727 10.1371/journal.pone.0010947 10.1038/379131a0 10.1016/j.cell.2010.03.026 10.1038/226961a0 10.1073/pnas.0610946104 10.1038/nature02222 10.1126/science.1092674 10.1038/nature04155 10.1073/pnas.0810683106 10.1101/gad.11.2.156 10.1089/153623003772032808 10.1159/000076310 10.1126/science.1084274 10.1126/science.1160952 10.1242/dev.127.19.4137 10.1126/science.1113673 |
| ContentType | Journal Article |
| Copyright | Springer Nature Limited 2011 2015 INIST-CNRS COPYRIGHT 2011 Nature Publishing Group Copyright Nature Publishing Group Apr 21, 2011 Distributed under a Creative Commons Attribution 4.0 International License |
| Copyright_xml | – notice: Springer Nature Limited 2011 – notice: 2015 INIST-CNRS – notice: COPYRIGHT 2011 Nature Publishing Group – notice: Copyright Nature Publishing Group Apr 21, 2011 – notice: Distributed under a Creative Commons Attribution 4.0 International License |
| DBID | AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 3V. 7QG 7QL 7QP 7QR 7RV 7SN 7SS 7ST 7T5 7TG 7TK 7TM 7TO 7U9 7X2 7X7 7XB 88A 88E 88G 88I 8AF 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK 8G5 ABJCF ABUWG AEUYN AFKRA ARAPS ATCPS AZQEC BBNVY BEC BENPR BGLVJ BHPHI BKSAR C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ GUQSH H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M2M M2O M2P M7N M7P M7S MBDVC NAPCQ P5Z P62 P64 PATMY PCBAR PDBOC PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PSYQQ PTHSS PYCSY Q9U R05 RC3 S0X SOI 7X8 1XC VOOES |
| DOI | 10.1038/nature09872 |
| DatabaseName | CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Nursing & Allied Health Database Ecology Abstracts Entomology Abstracts (Full archive) Environment Abstracts Immunology Abstracts Meteorological & Geoastrophysical Abstracts Neurosciences Abstracts Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Virology and AIDS Abstracts Agricultural Science Collection Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) Psychology Database (Alumni) Science Database (Alumni Edition) STEM Database ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Journals Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Research Library Materials Science & Engineering Collection ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland Advanced Technologies & Aerospace Collection Agricultural & Environmental Science Collection ProQuest Central Essentials ProQuest Biological Science Collection eLibrary Curriculum ProQuest Central Technology Collection Natural Science Collection Earth, Atmospheric & Aquatic Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Materials Science Collection ProQuest Central Korea Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student ProQuest Research Library AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection ProQuest Biological Science Collection Agricultural Science Database ProQuest Health & Medical Collection PML(ProQuest Medical Library) Psychology Database Research Library Science Database Algology Mycology and Protozoology Abstracts (Microbiology C) ProQuest Biological Science Database (NC LIVE) Engineering Database Research Library (Corporate) Nursing & Allied Health Premium Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Earth, Atmospheric & Aquatic Science Database Materials Science Collection ProQuest Central Premium ProQuest One Academic ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest One Psychology Engineering Collection Environmental Science Collection ProQuest Central Basic University of Michigan Genetics Abstracts SIRS Editorial Environment Abstracts MEDLINE - Academic Hyper Article en Ligne (HAL) Hyper Article en Ligne (HAL) (Open Access) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Agricultural Science Database ProQuest One Psychology Research Library Prep ProQuest Central Student Oncogenes and Growth Factors Abstracts ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts elibrary ProQuest AP Science SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Health & Medical Research Collection Biological Science Collection Chemoreception Abstracts ProQuest Central (New) ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Earth, Atmospheric & Aquatic Science Database Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts Meteorological & Geoastrophysical Abstracts - Academic ProQuest One Academic (New) University of Michigan Technology Collection Technology Research Database ProQuest One Academic Middle East (New) SIRS Editorial Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing Research Library (Alumni Edition) ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Biology Journals (Alumni Edition) ProQuest Central Earth, Atmospheric & Aquatic Science Collection ProQuest Health & Medical Research Collection Genetics Abstracts ProQuest Engineering Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Research Library ProQuest Materials Science Collection ProQuest Public Health ProQuest Central Basic ProQuest Science Journals ProQuest Nursing & Allied Health Source ProQuest Psychology Journals (Alumni) ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library ProQuest Psychology Journals Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts Environment Abstracts ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE Genetics Abstracts Agricultural Science Database |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: 8FG name: ProQuest Technology Collection url: https://search.proquest.com/technologycollection1 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Sciences (General) Physics |
| EISSN | 1476-4687 |
| EndPage | 374 |
| ExternalDocumentID | oai_HAL_hal_01019321v1 2337972631 A632494872 21471966 24070021 10_1038_nature09872 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Comparative Study |
| GeographicLocations | France |
| GeographicLocations_xml | – name: France |
| GroupedDBID | --- --Z -DZ -ET -~X .55 .CO .HR .XZ 00M 07C 08P 0R~ 0WA 123 186 1OL 1VR 29M 2KS 2XV 39C 3V. 4.4 41X 53G 5RE 6TJ 70F 7RV 7X2 7X7 7XC 85S 88A 88E 88I 8AF 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ 8G5 8R4 8R5 8WZ 97F 97L A6W A7Z A8Z AAEEF AAHBH AAHTB AAIKC AAKAB AAKAS AAMNW AASDW AAYEP AAYZH ABAWZ ABDBF ABDQB ABFSI ABIVO ABJCF ABJNI ABLJU ABNNU ABOCM ABPEJ ABPPZ ABUWG ABWJO ABZEH ACBEA ACBWK ACGFO ACGFS ACGOD ACIWK ACKOT ACMJI ACNCT ACPRK ACRPL ACUHS ACWUS ADBBV ADFRT ADNMO ADUKH ADYSU ADZCM AENEX AEUYN AFFNX AFKRA AFLOW AFRAH AFSHS AGAYW AGCDD AGGDT AGHSJ AGHTU AGNAY AGSOS AHMBA AHSBF AIDAL AIDUJ AIYXT ALFFA ALIPV ALMA_UNASSIGNED_HOLDINGS AMTXH APEBS ARAPS ARMCB ARTTT ASPBG ATCPS ATWCN AVWKF AXYYD AZFZN AZQEC B0M BBNVY BCR BCU BDKGC BEC BENPR BES BGLVJ BHPHI BIN BKEYQ BKKNO BKSAR BLC BPHCQ BVXVI CCPQU CJ0 CS3 D1I D1J D1K DO4 DU5 DWQXO E.- E.L EAD EAP EAS EAZ EBC EBD EBO EBS ECC EE. EJD EMB EMF EMH EMK EMOBN EPL EPS ESE ESN ESX EX3 EXGXG F5P FEDTE FQGFK FSGXE FYUFA GNUQQ GUQSH HCIFZ HMCUK HVGLF HZ~ I-F IAO ICQ IEA IEP IGS IH2 IHR INH INR IOF IPY ISR ITC K6- KB. KOO L-9 L6V L7B LK5 LK8 LSO M0K M0L M1P M2M M2O M2P M7P M7R M7S N9A NAPCQ NEJ NEPJS O9- OBC OES OHH OHT OMK OVD P-O P2P P62 PATMY PCBAR PDBOC PEA PKN PM3 PQQKQ PROAC PSQYO PSYQQ PTHSS PYCSY Q2X R05 RND RNS RNT RNTTT RXW S0X SC5 SHXYY SIXXV SJFOW SJN SNYQT SOJ SV3 TAE TAOOD TBHMF TDRGL TEORI TH9 TN5 TSG TUS TWZ U5U UIG UKHRP UKR UMD UQL VQA VVN WH7 WOW X7M XIH XKW XZL Y6R YAE YCJ YFH YIF YIN YNT YOC YQT YR2 YR5 YXB YZZ Z5M ZCA ZE2 ZKB ~02 ~7V ~88 ~8M ~G0 ~KM AARCD AAYXX ABFSG ACMFV ACSTC ADGHP ADXHL AETEA AFANA AGQPQ ALPWD ATHPR CITATION PHGZM PHGZT .-4 .GJ 1CY 1VW 354 3EH 3O- 41~ 42X 4R4 663 79B 9M8 AAJYS AAVBQ ABDPE ABEFU ACBNA ACBTR ACTDY ADRHT AEZWR AFBBN AFFDN AFHIU AFHKK AHWEU AIXLP AJUXI BKOMP DB5 FA8 FAC HG6 IQODW J5H LGEZI LOTEE MVM N4W NADUK NFIDA NXXTH ODYON PJZUB PPXIY PQGLB PV9 QS- R4F RHI SKT TUD UBY UHB USG VOH X7L XOL YJ6 YQI YQJ YV5 YXA YYP YYQ ZCG ZGI ZHY ZY4 CGR CUY CVF ECM EIF NPM AEIIB PMFND 7QG 7QL 7QP 7QR 7SN 7SS 7ST 7T5 7TG 7TK 7TM 7TO 7U9 7XB 8FD 8FK C1K FR3 H94 K9. KL. M7N MBDVC P64 PKEHL PQEST PQUKI PRINS Q9U RC3 SOI 7X8 1XC AAYOK VOOES |
| ID | FETCH-LOGICAL-c640t-3428efcc557bd3a75b40f169869c7842c28fc9bc9a105f7a717794ec6cd0fbeb3 |
| IEDL.DBID | 8FG |
| ISSN | 0028-0836 1476-4687 |
| IngestDate | Thu Jun 12 06:25:07 EDT 2025 Mon Jul 21 11:59:11 EDT 2025 Fri Jul 11 09:01:40 EDT 2025 Fri Jul 25 09:08:10 EDT 2025 Tue Jun 17 21:40:44 EDT 2025 Tue Jun 10 15:33:13 EDT 2025 Fri Jun 27 04:15:41 EDT 2025 Mon Jul 21 06:06:39 EDT 2025 Mon Jul 21 09:17:11 EDT 2025 Tue Jul 01 02:00:31 EDT 2025 Thu Apr 24 23:04:37 EDT 2025 Fri Feb 21 02:37:58 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 7343 |
| Keywords | Development Strategy Vertebrata Mammalia X-Chromosome Inactivation |
| Language | English |
| License | CC BY 4.0 Distributed under a Creative Commons Attribution 4.0 International License: http://creativecommons.org/licenses/by/4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c640t-3428efcc557bd3a75b40f169869c7842c28fc9bc9a105f7a717794ec6cd0fbeb3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Feature-1 content type line 23 |
| ORCID | 0000-0002-1126-4322 0000-0001-8120-7481 0000-0002-2251-1296 |
| OpenAccessLink | https://hal.science/hal-01019321 |
| PMID | 21471966 |
| PQID | 864819821 |
| PQPubID | 40569 |
| PageCount | 5 |
| ParticipantIDs | hal_primary_oai_HAL_hal_01019321v1 proquest_miscellaneous_902338607 proquest_miscellaneous_863426442 proquest_journals_864819821 gale_infotracmisc_A632494872 gale_infotraccpiq_632494872 gale_incontextgauss_ISR_A632494872 pubmed_primary_21471966 pascalfrancis_primary_24070021 crossref_primary_10_1038_nature09872 crossref_citationtrail_10_1038_nature09872 springer_journals_10_1038_nature09872 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2011-04-21 |
| PublicationDateYYYYMMDD | 2011-04-21 |
| PublicationDate_xml | – month: 04 year: 2011 text: 2011-04-21 day: 21 |
| PublicationDecade | 2010 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England |
| PublicationSubtitle | International weekly journal of science |
| PublicationTitle | Nature (London) |
| PublicationTitleAbbrev | Nature |
| PublicationTitleAlternate | Nature |
| PublicationYear | 2011 |
| Publisher | Nature Publishing Group UK Nature Publishing Group |
| Publisher_xml | – name: Nature Publishing Group UK – name: Nature Publishing Group |
| References | Fauque (CR33) 2010; 94 Mak (CR5) 2004; 303 Takagi, Sasaki (CR7) 1975; 256 Migeon (CR22) 2002; 99 Silva (CR20) 2003; 4 Moreira de Mello (CR23) 2010; 5 Patrat (CR4) 2009; 106 Sharman (CR2) 1971; 230 Penny, Kay, Sheardown, Rastan, Brockdorff (CR8) 1996; 379 Hajjoubi (CR14) 2006; 370 Flach (CR17) 1982; 1 Marahrens, Panning, Dausman, Strauss, Jaenisch (CR9) 1997; 11 Duret, Chureau, Samain, Weissenbach, Avner (CR12) 2006; 312 Christians, Rao, Renard (CR16) 1994; 164 Huynh, Lee (CR3) 2003; 426 Monkhorst, Jonkers, Rentmeester, Grosveld, Gribnau (CR18) 2008; 132 van den Berg (CR21) 2009; 84 Chang, Brown (CR29) 2010; 11 Challah-Jacques, Chesne, Renard (CR32) 2003; 5 Okamoto, Heard (CR13) 2009; 17 Chesné (CR31) 2002; 20 Kay, Barton, Surani, Rastan (CR10) 1994; 77 Chantry-Darmon (CR36) 2003; 103 Huang, Madan (CR37) 1999; 9 CR28 Navarro (CR30) 2008; 231 Chow (CR38) 2007; 104 Navarro, Avner (CR11) 2010; 32 Okamoto, Tan, Takagi (CR27) 2000; 127 Gardner, Schoolcraft, Jansen, Mortimer (CR34) 1999 Okamoto, Otte, Allis, Reinberg, Heard (CR6) 2004; 303 Lenger (CR25) 2010; 141 Lyon (CR1) 1961; 190 Manes (CR15) 1973; 32 Barlow, Vosal (CR24) 1970; 226 Plath (CR19) 2003; 300 Okamoto (CR26) 2005; 438 Hayes (CR35) 2002; 98 P Navarro (BFnature09872_CR11) 2010; 32 I Okamoto (BFnature09872_CR13) 2009; 17 M Challah-Jacques (BFnature09872_CR32) 2003; 5 DK Gardner (BFnature09872_CR34) 1999 N Takagi (BFnature09872_CR7) 1975; 256 P Chesné (BFnature09872_CR31) 2002; 20 K Monkhorst (BFnature09872_CR18) 2008; 132 JC Chow (BFnature09872_CR38) 2007; 104 C Patrat (BFnature09872_CR4) 2009; 106 MF Lyon (BFnature09872_CR1) 1961; 190 C Chantry-Darmon (BFnature09872_CR36) 2003; 103 L Duret (BFnature09872_CR12) 2006; 312 SC Chang (BFnature09872_CR29) 2010; 11 S Hajjoubi (BFnature09872_CR14) 2006; 370 GD Penny (BFnature09872_CR8) 1996; 379 X Huang (BFnature09872_CR37) 1999; 9 J Silva (BFnature09872_CR20) 2003; 4 H Hayes (BFnature09872_CR35) 2002; 98 C Manes (BFnature09872_CR15) 1973; 32 I Okamoto (BFnature09872_CR27) 2000; 127 JC Moreira de Mello (BFnature09872_CR23) 2010; 5 E Christians (BFnature09872_CR16) 1994; 164 W Mak (BFnature09872_CR5) 2004; 303 K Plath (BFnature09872_CR19) 2003; 300 BFnature09872_CR28 Y Marahrens (BFnature09872_CR9) 1997; 11 CJ Lenger (BFnature09872_CR25) 2010; 141 GF Kay (BFnature09872_CR10) 1994; 77 P Navarro (BFnature09872_CR30) 2008; 231 P Fauque (BFnature09872_CR33) 2010; 94 KD Huynh (BFnature09872_CR3) 2003; 426 IM van den Berg (BFnature09872_CR21) 2009; 84 I Okamoto (BFnature09872_CR6) 2004; 303 G Flach (BFnature09872_CR17) 1982; 1 B Migeon (BFnature09872_CR22) 2002; 99 P Barlow (BFnature09872_CR24) 1970; 226 GB Sharman (BFnature09872_CR2) 1971; 230 I Okamoto (BFnature09872_CR26) 2005; 438 16778056 - Science. 2006 Jun 16;312(5780):1653-5 20532033 - PLoS One. 2010 Jun 04;5(6):e10947 15004485 - Cytogenet Genome Res. 2003;103(1-2):192-201 16227973 - Nature. 2005 Nov 17;438(7066):369-73 19481196 - Am J Hum Genet. 2009 Jun;84(6):771-9 4789702 - Dev Biol. 1973 Jun;32(2):453-9 8205614 - Cell. 1994 Jun 3;77(5):639-50 19273861 - Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5198-203 10508846 - Genome Res. 1999 Sep;9(9):868-77 14671313 - Science. 2004 Jan 30;303(5658):644-9 20471072 - Cell. 2010 May 28;141(5):872-83 8026620 - Dev Biol. 1994 Jul;164(1):160-72 18802003 - Science. 2008 Sep 19;321(5896):1693-5 16051795 - Science. 2005 Jul 29;309(5735):768-71 14752160 - Science. 2004 Jan 30;303(5658):666-9 11923842 - Nat Biotechnol. 2002 Apr;20(4):366-9 20544740 - Bioessays. 2010 Jul;32(7):581-8 14733748 - Cloning Stem Cells. 2003;5(4):295-9 Nature. 2011 Jun 9;474(7350):239-40 4926712 - Nature. 1971 Mar 26;230(5291):231-2 19446806 - Fertil Steril. 2010 Aug;94(3):927-35 17537922 - Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10104-9 8538762 - Nature. 1996 Jan 11;379(6561):131-7 9009199 - Genes Dev. 1997 Jan 15;11(2):156-66 12649488 - Science. 2003 Apr 4;300(5616):131-5 19802706 - Chromosome Res. 2009;17(5):659-69 18267073 - Cell. 2008 Feb 8;132(3):410-21 12698004 - Cytogenet Genome Res. 2002;98(2-3):199-205 20211024 - BMC Mol Biol. 2010 Mar 08;11:20 16483732 - Gene. 2006 Mar 29;370:104-12 12689588 - Dev Cell. 2003 Apr;4(4):481-95 4192297 - Nature. 1970 Jun 6;226(5249):961-2 13764598 - Nature. 1961 Apr 22;190:372-3 1152998 - Nature. 1975 Aug 21;256(5519):640-2 7188357 - EMBO J. 1982;1(6):681-6 10976046 - Development. 2000 Oct;127(19):4137-45 12900539 - Cytogenet Genome Res. 2002;99(1-4):8-16 14661031 - Nature. 2003 Dec 18;426(6968):857-62 |
| References_xml | – volume: 98 start-page: 199 year: 2002 end-page: 205 ident: CR35 article-title: Establishment of R-banded rabbit karyotype nomenclature by FISH localization of 23 chromosome-specific genes on both G- and R-banded chromosomes publication-title: Cytogenet. Genome Res. doi: 10.1159/000069807 – volume: 164 start-page: 160 year: 1994 end-page: 172 ident: CR16 article-title: Sequential acquisition of transcriptional control during early embryonic development in the rabbit publication-title: Dev. Biol. doi: 10.1006/dbio.1994.1188 – volume: 1 start-page: 681 year: 1982 end-page: 686 ident: CR17 article-title: The transition from maternal to embryonic control in the 2-cell mouse embryo publication-title: EMBO J. doi: 10.1002/j.1460-2075.1982.tb01230.x – volume: 94 start-page: 927 year: 2010 end-page: 935 ident: CR33 article-title: Cumulative results including obstetrical and neonatal outcome of fresh and frozen-thawed cycles in elective single versus double fresh embryo transfers publication-title: Fertil. Steril. doi: 10.1016/j.fertnstert.2009.03.105 – volume: 230 start-page: 231 year: 1971 end-page: 232 ident: CR2 article-title: Late DNA replication in the paternally derived X-chromosome of female kangaroos publication-title: Nature doi: 10.1038/230231a0 – volume: 312 start-page: 1653 year: 2006 end-page: 1655 ident: CR12 article-title: The Xist RNA gene evolved in eutherians by pseudogenization of a protein-coding gene publication-title: Science doi: 10.1126/science.1126316 – volume: 32 start-page: 453 year: 1973 end-page: 459 ident: CR15 article-title: The participation of the embryonic genome during early cleavage in the rabbit publication-title: Dev. Biol. doi: 10.1016/0012-1606(73)90254-6 – volume: 17 start-page: 659 year: 2009 end-page: 669 ident: CR13 article-title: Lessons from comparative analysis of X-chromosome inactivation in mammals publication-title: Chromosome Res. doi: 10.1007/s10577-009-9057-7 – volume: 4 start-page: 481 year: 2003 end-page: 495 ident: CR20 article-title: Establishment of histone h3 methylation on the inactive X chromosome requires transient recruitment of Eed-Enx1 polycomb group complexes publication-title: Dev. Cell doi: 10.1016/S1534-5807(03)00068-6 – volume: 190 start-page: 372 year: 1961 end-page: 373 ident: CR1 article-title: Gene action in the X-chromosome of the mouse ( L.) publication-title: Nature doi: 10.1038/190372a0 – volume: 11 start-page: 20 year: 2010 ident: CR29 article-title: Identification of regulatory elements flanking human XIST reveals species differences publication-title: BMC Mol. Biol. doi: 10.1186/1471-2199-11-20 – volume: 132 start-page: 410 year: 2008 end-page: 421 ident: CR18 article-title: X inactivation counting and choice is a stochastic process: evidence for involvement of an X-linked activator publication-title: Cell doi: 10.1016/j.cell.2007.12.036 – volume: 77 start-page: 639 year: 1994 end-page: 650 ident: CR10 article-title: Imprinting and X chromosome counting mechanisms determine Xist expression in early mouse development publication-title: Cell doi: 10.1016/0092-8674(94)90049-3 – volume: 20 start-page: 366 year: 2002 end-page: 369 ident: CR31 article-title: Cloned rabbits produced by nuclear transfer from adult somatic cells publication-title: Nature Biotechnol. doi: 10.1038/nbt0402-366 – volume: 84 start-page: 771 year: 2009 end-page: 779 ident: CR21 article-title: X chromosome inactivation is initiated in human preimplantation embryos publication-title: Am. J. Hum. Genet. doi: 10.1016/j.ajhg.2009.05.003 – volume: 256 start-page: 640 year: 1975 end-page: 642 ident: CR7 article-title: Preferential inactivation of the paternally derived X-chromosome in the extraembryonic membranes of the mouse publication-title: Nature doi: 10.1038/256640a0 – volume: 32 start-page: 581 year: 2010 end-page: 588 ident: CR11 article-title: An embryonic story: analysis of the gene regulative network controlling Xist expression in mouse embryonic stem cells publication-title: Bioessays doi: 10.1002/bies.201000019 – volume: 370 start-page: 104 year: 2006 end-page: 112 ident: CR14 article-title: Ruminants genome no longer contains Whey Acidic Protein gene but only a pseudogene publication-title: Gene doi: 10.1016/j.gene.2005.11.025 – volume: 99 start-page: 8 year: 2002 end-page: 16 ident: CR22 article-title: X-chromosome inactivation: theme and variations publication-title: Cytogenet. Genome Res. doi: 10.1159/000071568 – volume: 127 start-page: 4137 year: 2000 end-page: 4145 ident: CR27 article-title: X-chromosome inactivation in XX androgenetic mouse embryos surviving implantation publication-title: Development – volume: 9 start-page: 868 year: 1999 end-page: 877 ident: CR37 article-title: CAP3: A DNA sequence assembly program publication-title: Genome Res. doi: 10.1101/gr.9.9.868 – volume: 303 start-page: 644 year: 2004 end-page: 649 ident: CR6 article-title: Epigenetic dynamics of imprinted X inactivation during early mouse development publication-title: Science doi: 10.1126/science.1092727 – volume: 5 start-page: e10947 year: 2010 ident: CR23 article-title: Random X inactivation and extensive mosaicism in human placenta revealed by analysis of allele-specific gene expression along the X chromosome publication-title: PLoS ONE doi: 10.1371/journal.pone.0010947 – volume: 379 start-page: 131 year: 1996 end-page: 137 ident: CR8 article-title: Requirement for in X chromosome inactivation publication-title: Nature doi: 10.1038/379131a0 – volume: 141 start-page: 1 year: 2010 end-page: 12 ident: CR25 article-title: Derivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations publication-title: Cell doi: 10.1016/j.cell.2010.03.026 – volume: 226 start-page: 961 year: 1970 end-page: 962 ident: CR24 article-title: The Y chromosome in human spermatozoa publication-title: Nature doi: 10.1038/226961a0 – volume: 104 start-page: 10104 year: 2007 end-page: 10109 ident: CR38 article-title: Inducible XIST-dependent X-chromosome inactivation in human somatic cells is reversible publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0610946104 – volume: 426 start-page: 857 year: 2003 end-page: 862 ident: CR3 article-title: Inheritance of a pre-inactivated paternal chromosome in early mouse embryos publication-title: Nature doi: 10.1038/nature02222 – volume: 303 start-page: 666 year: 2004 end-page: 669 ident: CR5 article-title: Reactivation of the paternal X chromosome in early mouse embryos publication-title: Science doi: 10.1126/science.1092674 – volume: 438 start-page: 369 year: 2005 end-page: 373 ident: CR26 article-title: Evidence for de novo imprinted X-chromosome inactivation independent of meiotic inactivation in mice publication-title: Nature doi: 10.1038/nature04155 – volume: 106 start-page: 5198 year: 2009 end-page: 5203 ident: CR4 article-title: Dynamic changes in paternal X-chromosome activity during imprinted X-chromosome inactivation in mice publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0810683106 – volume: 11 start-page: 156 year: 1997 end-page: 166 ident: CR9 article-title: -deficient mice are defective in dosage compensation but not spermatogenesis publication-title: Genes Dev. doi: 10.1101/gad.11.2.156 – volume: 5 start-page: 295 year: 2003 end-page: 299 ident: CR32 article-title: Production of cloned rabbits by somatic nuclear transfer publication-title: Cloning Stem Cells doi: 10.1089/153623003772032808 – volume: 103 start-page: 192 year: 2003 end-page: 201 ident: CR36 article-title: 133 new gene localization on the rabbit cytogenetic map publication-title: Cytogenet. Genome Res. doi: 10.1159/000076310 – start-page: 378 year: 1999 end-page: 388 ident: CR34 publication-title: Towards Reproductive Certainty: Infertility and Genetics Beyond 1999 – ident: CR28 – volume: 300 start-page: 131 year: 2003 end-page: 135 ident: CR19 article-title: Role of histone H3 lysine 27 methylation in X inactivation publication-title: Science doi: 10.1126/science.1084274 – volume: 231 start-page: 1693 year: 2008 end-page: 1695 ident: CR30 article-title: Molecular coupling of regulation and pluripotency publication-title: Science doi: 10.1126/science.1160952 – start-page: 378 volume-title: Towards Reproductive Certainty: Infertility and Genetics Beyond 1999 year: 1999 ident: BFnature09872_CR34 – volume: 127 start-page: 4137 year: 2000 ident: BFnature09872_CR27 publication-title: Development doi: 10.1242/dev.127.19.4137 – volume: 231 start-page: 1693 year: 2008 ident: BFnature09872_CR30 publication-title: Science doi: 10.1126/science.1160952 – volume: 164 start-page: 160 year: 1994 ident: BFnature09872_CR16 publication-title: Dev. Biol. doi: 10.1006/dbio.1994.1188 – volume: 132 start-page: 410 year: 2008 ident: BFnature09872_CR18 publication-title: Cell doi: 10.1016/j.cell.2007.12.036 – volume: 303 start-page: 666 year: 2004 ident: BFnature09872_CR5 publication-title: Science doi: 10.1126/science.1092674 – volume: 226 start-page: 961 year: 1970 ident: BFnature09872_CR24 publication-title: Nature doi: 10.1038/226961a0 – volume: 17 start-page: 659 year: 2009 ident: BFnature09872_CR13 publication-title: Chromosome Res. doi: 10.1007/s10577-009-9057-7 – volume: 438 start-page: 369 year: 2005 ident: BFnature09872_CR26 publication-title: Nature doi: 10.1038/nature04155 – volume: 5 start-page: e10947 year: 2010 ident: BFnature09872_CR23 publication-title: PLoS ONE doi: 10.1371/journal.pone.0010947 – volume: 256 start-page: 640 year: 1975 ident: BFnature09872_CR7 publication-title: Nature doi: 10.1038/256640a0 – volume: 94 start-page: 927 year: 2010 ident: BFnature09872_CR33 publication-title: Fertil. Steril. doi: 10.1016/j.fertnstert.2009.03.105 – volume: 11 start-page: 156 year: 1997 ident: BFnature09872_CR9 publication-title: Genes Dev. doi: 10.1101/gad.11.2.156 – volume: 1 start-page: 681 year: 1982 ident: BFnature09872_CR17 publication-title: EMBO J. doi: 10.1002/j.1460-2075.1982.tb01230.x – volume: 98 start-page: 199 year: 2002 ident: BFnature09872_CR35 publication-title: Cytogenet. Genome Res. doi: 10.1159/000069807 – volume: 9 start-page: 868 year: 1999 ident: BFnature09872_CR37 publication-title: Genome Res. doi: 10.1101/gr.9.9.868 – volume: 370 start-page: 104 year: 2006 ident: BFnature09872_CR14 publication-title: Gene doi: 10.1016/j.gene.2005.11.025 – volume: 104 start-page: 10104 year: 2007 ident: BFnature09872_CR38 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0610946104 – volume: 379 start-page: 131 year: 1996 ident: BFnature09872_CR8 publication-title: Nature doi: 10.1038/379131a0 – volume: 11 start-page: 20 year: 2010 ident: BFnature09872_CR29 publication-title: BMC Mol. Biol. doi: 10.1186/1471-2199-11-20 – volume: 20 start-page: 366 year: 2002 ident: BFnature09872_CR31 publication-title: Nature Biotechnol. doi: 10.1038/nbt0402-366 – volume: 300 start-page: 131 year: 2003 ident: BFnature09872_CR19 publication-title: Science doi: 10.1126/science.1084274 – volume: 303 start-page: 644 year: 2004 ident: BFnature09872_CR6 publication-title: Science doi: 10.1126/science.1092727 – volume: 84 start-page: 771 year: 2009 ident: BFnature09872_CR21 publication-title: Am. J. Hum. Genet. doi: 10.1016/j.ajhg.2009.05.003 – volume: 103 start-page: 192 year: 2003 ident: BFnature09872_CR36 publication-title: Cytogenet. Genome Res. doi: 10.1159/000076310 – ident: BFnature09872_CR28 doi: 10.1126/science.1113673 – volume: 32 start-page: 453 year: 1973 ident: BFnature09872_CR15 publication-title: Dev. Biol. doi: 10.1016/0012-1606(73)90254-6 – volume: 141 start-page: 1 year: 2010 ident: BFnature09872_CR25 publication-title: Cell doi: 10.1016/j.cell.2010.03.026 – volume: 4 start-page: 481 year: 2003 ident: BFnature09872_CR20 publication-title: Dev. Cell doi: 10.1016/S1534-5807(03)00068-6 – volume: 190 start-page: 372 year: 1961 ident: BFnature09872_CR1 publication-title: Nature doi: 10.1038/190372a0 – volume: 99 start-page: 8 year: 2002 ident: BFnature09872_CR22 publication-title: Cytogenet. Genome Res. doi: 10.1159/000071568 – volume: 5 start-page: 295 year: 2003 ident: BFnature09872_CR32 publication-title: Cloning Stem Cells doi: 10.1089/153623003772032808 – volume: 106 start-page: 5198 year: 2009 ident: BFnature09872_CR4 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0810683106 – volume: 77 start-page: 639 year: 1994 ident: BFnature09872_CR10 publication-title: Cell doi: 10.1016/0092-8674(94)90049-3 – volume: 312 start-page: 1653 year: 2006 ident: BFnature09872_CR12 publication-title: Science doi: 10.1126/science.1126316 – volume: 230 start-page: 231 year: 1971 ident: BFnature09872_CR2 publication-title: Nature doi: 10.1038/230231a0 – volume: 32 start-page: 581 year: 2010 ident: BFnature09872_CR11 publication-title: Bioessays doi: 10.1002/bies.201000019 – volume: 426 start-page: 857 year: 2003 ident: BFnature09872_CR3 publication-title: Nature doi: 10.1038/nature02222 – reference: 16778056 - Science. 2006 Jun 16;312(5780):1653-5 – reference: 18802003 - Science. 2008 Sep 19;321(5896):1693-5 – reference: 12698004 - Cytogenet Genome Res. 2002;98(2-3):199-205 – reference: 14671313 - Science. 2004 Jan 30;303(5658):644-9 – reference: 14733748 - Cloning Stem Cells. 2003;5(4):295-9 – reference: 12689588 - Dev Cell. 2003 Apr;4(4):481-95 – reference: 4926712 - Nature. 1971 Mar 26;230(5291):231-2 – reference: 17537922 - Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10104-9 – reference: 8205614 - Cell. 1994 Jun 3;77(5):639-50 – reference: 20471072 - Cell. 2010 May 28;141(5):872-83 – reference: 20211024 - BMC Mol Biol. 2010 Mar 08;11:20 – reference: 8538762 - Nature. 1996 Jan 11;379(6561):131-7 – reference: 19481196 - Am J Hum Genet. 2009 Jun;84(6):771-9 – reference: 12649488 - Science. 2003 Apr 4;300(5616):131-5 – reference: 18267073 - Cell. 2008 Feb 8;132(3):410-21 – reference: 4192297 - Nature. 1970 Jun 6;226(5249):961-2 – reference: 16051795 - Science. 2005 Jul 29;309(5735):768-71 – reference: 20544740 - Bioessays. 2010 Jul;32(7):581-8 – reference: 9009199 - Genes Dev. 1997 Jan 15;11(2):156-66 – reference: 19802706 - Chromosome Res. 2009;17(5):659-69 – reference: 10976046 - Development. 2000 Oct;127(19):4137-45 – reference: 1152998 - Nature. 1975 Aug 21;256(5519):640-2 – reference: 7188357 - EMBO J. 1982;1(6):681-6 – reference: 11923842 - Nat Biotechnol. 2002 Apr;20(4):366-9 – reference: 14661031 - Nature. 2003 Dec 18;426(6968):857-62 – reference: 16227973 - Nature. 2005 Nov 17;438(7066):369-73 – reference: 13764598 - Nature. 1961 Apr 22;190:372-3 – reference: 16483732 - Gene. 2006 Mar 29;370:104-12 – reference: 8026620 - Dev Biol. 1994 Jul;164(1):160-72 – reference: 14752160 - Science. 2004 Jan 30;303(5658):666-9 – reference: 20532033 - PLoS One. 2010 Jun 04;5(6):e10947 – reference: 12900539 - Cytogenet Genome Res. 2002;99(1-4):8-16 – reference: 4789702 - Dev Biol. 1973 Jun;32(2):453-9 – reference: 19273861 - Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5198-203 – reference: 15004485 - Cytogenet Genome Res. 2003;103(1-2):192-201 – reference: 19446806 - Fertil Steril. 2010 Aug;94(3):927-35 – reference: - Nature. 2011 Jun 9;474(7350):239-40 – reference: 10508846 - Genome Res. 1999 Sep;9(9):868-77 |
| SSID | ssj0005174 |
| Score | 2.5247328 |
| Snippet | Mice out of step on X inactivation
X-chromosome inactivation is an essential process in female mammals that compensates for the presence of two X-chromosomes... X-chromosome inactivation (XCI) in female mammals allows dosage compensation for X-linked gene products between the sexes. The developmental regulation of this... Mice out of step on X inactivation X-chromosome inactivation (XCI) in female mammals allows dosage compensation for X-linked gene products between the sexes1. The developmental regulation of... |
| SourceID | hal proquest gale pubmed pascalfrancis crossref springer |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 370 |
| SubjectTerms | 631/136/2086 631/208/182 631/337/176/1433 Animal development Animals Biological and medical sciences Biological Evolution Blastocyst - metabolism Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Chromosomes Chromosomes, Mammalian - genetics Compensation Development Biology Dosage Compensation, Genetic - genetics Embryo, Mammalian - embryology Embryo, Mammalian - metabolism Embryonic growth stage Eutherians Female Females Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Developmental - genetics Genes, X-Linked - genetics Genetic aspects Genetic engineering Genomic Imprinting - genetics Histones - metabolism Humanities and Social Sciences Humans Hypoxanthine Phosphoribosyltransferase - genetics Inactivation letter Life Sciences Male Males Mammals Mammals - embryology Mammals - genetics Mice Molecular and cellular biology multidisciplinary Observations Parthenogenesis Physiological aspects Rabbits Reproductive Biology RNA, Long Noncoding RNA, Untranslated - genetics Science Science (multidisciplinary) Species Specificity Up-Regulation - genetics X Chromosome - genetics X chromosome inactivation X Chromosome Inactivation - genetics |
| Title | Eutherian mammals use diverse strategies to initiate X-chromosome inactivation during development |
| URI | https://link.springer.com/article/10.1038/nature09872 https://www.ncbi.nlm.nih.gov/pubmed/21471966 https://www.proquest.com/docview/864819821 https://www.proquest.com/docview/863426442 https://www.proquest.com/docview/902338607 https://hal.science/hal-01019321 |
| Volume | 472 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3fa9swED6WlsFgjLX75bULonSwDUwtW5blp5GVZNnYyuhWyJuxZHktNHZaJ_v7d2crSbNlezHYOiMhnaTvpE-fAI6jOAkRBglf5knhCyOkr7QQPh3qzEuplW538L-eyfGF-DyJJ46b0zha5XJMbAfqoja0Rn6ipMDJS4X8_ezGp0ujaHPV3aDRg12OEw0xutTo45rh8YcIszueF0TqpFPNDDDgDjcmJDcs9y6JFflwljdYUWV3w8U2CPrX9mk7K40ewyMHJ9mga_89uGerfbjf0jpNsw97rus27I3Tl377BPJhy2pHv2DTfDpF_2OLxrKiZWhY1syX6hFsXrMrIhfhO5v45pKoe009tfiVzkN0q7msO-nIijX96ClcjIY_Tse-u2nBN1IEcz_CIMSWxsRxoosoT2ItgpLLVMnUJEqEJlSlSbVJc4RjZZJjDIj92BppiqDUGI8_g52qruwLYIrHKhCWq5RbEeCPWmodiiKMYhPFgfXg3bK6M-NkyOk2jOus3Q6PVHanbTw4XhnPOvWN7WZH1G4Z6VlURJj5mS-aJvv0_TwbkBx9KlqjA2dU1pihMbOrm-xO6uFGKnYys_HzEbrEqgykyT0efMnoG4n0IQjmv7gH_Q2PWZlT1ExgCouwdKHMDRVNtnJsD9gqlbIn9ltl6wWZRC1wDf9tkiL2ipQMEg-ed765zp0jAMGo1oPXS2dd576lNl_-t5QH8KBbVhd-yA9hZ367sK8Ql811H3rJJMGnOuX9tif2YffD8Ozb-W-ppziW |
| linkProvider | ProQuest |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwED9tQwgkhNj4ChvDmjYJJkXLh-M4DwhVsNKyjwfYpL6Z2HHYJNp0pAXxR_E_cpePdoXC2x4bX2ord7Z_Z__uDmA3jOIAYRB3RRpnLjdcuFJz7lJQZ5oLLXV1g39yKnrn_MMgGqzArzYWhmiV7ZpYLdRZYeiM_EAKjpuXDPw34yuXikbR5WpbQaO2iiP78wd6bOXr_jtU714QdA_P3vbcpqiAawT3Jm6IeNvmxkRRrLMwjSPNvdwXiRSJiSUPTCBzk2iTpIg88jhFdwdN1hphMi_X6Hri_67CLR7iRk6B6d33c0bJH0mfm3BAL5QHdZZODx38YGEDbLaB1QtiYd4bpyUqJq8raiyDvH9d11a7YPcB3G_gK-vU9rYOK3a0AbcrGqkpN2C9WSpK9rLJZ_3qIaSHFYse7ZAN0-EQ7Z1NS8uyihFiWTlps1WwScEuicyEv9nANRdEFSyLocWnFH9Rnx6zOrKSZXO60yM4vxElPIa1UTGyT4FJP5Iet75MfMs9fFELrQOeBWFkwsizDuy3n1uZJu05Vd_4qqrr91Cqa7pxYHcmPK6zfSwX2yG9KcqfMSKCzpd0Wpaq_-mj6lD6-4RXQpuNUF5gh8aML6_UtdathVac1Gbh5R00idkYKAd4r3Os6BklBUTQ7X_3HdhesJiZOHnpBN5wCK0JqWZpKtVsIjnAZq3UPbHtRraYkkhYAeXg3yIJYr1QCi924Eltm_PefQQ86EU7sNca67z3JV_z2X9H-QLu9M5OjtVx__RoE-7WR_rcDfwtWJt8m9rniAkneruaiQw-3_TU_w1LqnLg |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1db9MwFLW2IRASQmx8hY1hTZsEk6ImjuM4DwhV26qWjQkBk_pmYsdhk2jTkRbET-PfcW--2kLhbY-Nb2orPtc-1z6-JmQ_CCMGNIi7IolSlxsuXKk5d_FQZ5IJLXW5g__uXPQv-NthOFwjv5qzMCirbMbEcqBOc4Nr5B0pOExekvmdrFZFvD_uvZlcu3iBFG60NrdpVAg5tT9_QPRWvB4cQ1cfMNY7-XTUd-sLBlwjuDd1A-DeNjMmDCOdBkkUau5lvoiliE0kOTNMZibWJk6AhWRRAqEPwNcaYVIv0xCGwv-uk1tREEl0MXm0oC75IwF0fTTQC2SnytjpQbDPlibDekpYv0RF5r1JUkAnZdXtGqvo719bt-WM2HtA7tdUlnYr7G2SNTveIrdLSakptshmPWwU9GWd2_rVQ5KclIp6wCQdJaMRYJ_OCkvTUh1iaTFtMlfQaU6vUNgEv-nQNZcoGyzykYWneBajWkmm1SlLms6lT4_IxY10wmOyMc7H9imh0g-lx60vY99yD17UQmvGUxaEJgg965DD5nMrU6dAx5s4vqpyKz6QaqFvHLLfGk-qzB-rzfaw3xTm0hgjLL8ks6JQg48fVBdT4ce8NNqujbIcKjRmcnWtFkp3lkrBwc3Sy3sAibYNmA-83z1T-AwTBAIB97_7DtldQkxrjhE7EjloQgMhVQ9ThWqdyiG0LcXqUXk3tvkMTYKSNLN_m8TA-wIpvMghTypszmv3gfxARO2Qgwas89pXfM1n_23lC3IHnF6dDc5Pt8ndanWfu8zfIRvTbzP7HOjhVO-WjkjJ55v2_N849nbh |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Eutherian+mammals+use+diverse+strategies+to+initiate+X-chromosome+inactivation+during+development&rft.jtitle=Nature+%28London%29&rft.au=Okamoto%2C+Ikuhiro&rft.au=Patrat%2C+Catherine&rft.au=Th%C3%A9pot%2C+Dominique&rft.au=Peynot%2C+Nathalie&rft.date=2011-04-21&rft.issn=1476-4687&rft.eissn=1476-4687&rft.volume=472&rft.issue=7343&rft.spage=370&rft_id=info:doi/10.1038%2Fnature09872&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0028-0836&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0028-0836&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0028-0836&client=summon |