Effects of tendon injury on uninjured regional tendons in the distal limb: An in-vivo study using an ovine tendinopathy model

• Published in: PloS one Vol. 14; no. 4; p. e0215830
• Main Authors: Tsang, Albert S, Dart, Andrew J, Biasutti, Sara A, Jeffcott, Leo B, Smith, Margaret M, Little, Christopher B
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 23.04.2019; Public Library of Science (PLoS)
• Subjects: Animals; Biochemistry; Collagen; Collagen - genetics; Development and progression; Disease Models, Animal; Extremities - physiopathology; Gene expression; Gene Expression Regulation - genetics; Genes; Genetic testing; Histochemistry; Humans; Polymerase chain reaction; Sheep; Sheep, Domestic - genetics; Sports injuries; Surgery; Tendinopathy - genetics; Tendinopathy - physiopathology; Tendon injuries; Tendon Injuries - genetics; Tendon Injuries - physiopathology; Tendons - metabolism; Tendons - physiopathology; Australia

Following injury to a tendon little is known about potential for pathology to develop in other regional tendons from overloading or altered function. The aim of this study was to investigate the gene expression and histopathological changes that occur 1) within the deep digital flexor tendon (DDFT)...