Effects of tendon injury on uninjured regional tendons in the distal limb: An in-vivo study using an ovine tendinopathy model

Following injury to a tendon little is known about potential for pathology to develop in other regional tendons from overloading or altered function. The aim of this study was to investigate the gene expression and histopathological changes that occur 1) within the deep digital flexor tendon (DDFT)...

Full description

Saved in:
Bibliographic Details
Published inPloS one Vol. 14; no. 4; p. e0215830
Main Authors Tsang, Albert S, Dart, Andrew J, Biasutti, Sara A, Jeffcott, Leo B, Smith, Margaret M, Little, Christopher B
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 23.04.2019
Public Library of Science (PLoS)
Subjects
Online AccessGet full text

Cover

Loading…
Abstract Following injury to a tendon little is known about potential for pathology to develop in other regional tendons from overloading or altered function. The aim of this study was to investigate the gene expression and histopathological changes that occur 1) within the deep digital flexor tendon (DDFT) after injury to the superficial digital flexor tendon (SDFT) and 2) within the flexor tendons (SDFT and DDFT) after injury to the extensor tendons. Merino wethers [Ovis aries] (n = 18) were divided into three equal groups and underwent either partial transection of the SDFT, complete transection of the extensor tendons or were left as non-operated controls. Tendons were harvested and sampled regionally for gene expression (real time PCR) and histologic analysis eight weeks after surgery. Transection of the SDFT resulted in increased expression of collagen III, versican, biglycan, lumican and MMP1 (P<0.026 for all genes) within the DDFT. There was no effect of transecting the extensor tendons on the expression of any gene tested in either the SDFT or the DDFT. The DDFT had elevated histopathology scores induced by transection of the SDFT, eight weeks previously. There were minimal histological differences in either the SDFT or DDFT after transection of the extensor tendons. Transection of the SDFT results in a mild, subclinical tendinopathy within the DDFT with potential implications on treatment and rehabilitation of SDFT injuries. Injury to the extensor tendons has minimal measured effect on the SDFT or DDFT.
AbstractList Following injury to a tendon little is known about potential for pathology to develop in other regional tendons from overloading or altered function. The aim of this study was to investigate the gene expression and histopathological changes that occur 1) within the deep digital flexor tendon (DDFT) after injury to the superficial digital flexor tendon (SDFT) and 2) within the flexor tendons (SDFT and DDFT) after injury to the extensor tendons. Merino wethers [Ovis aries] (n = 18) were divided into three equal groups and underwent either partial transection of the SDFT, complete transection of the extensor tendons or were left as non-operated controls. Tendons were harvested and sampled regionally for gene expression (real time PCR) and histologic analysis eight weeks after surgery. Transection of the SDFT resulted in increased expression of collagen III, versican, biglycan, lumican and MMP1 (P<0.026 for all genes) within the DDFT. There was no effect of transecting the extensor tendons on the expression of any gene tested in either the SDFT or the DDFT. The DDFT had elevated histopathology scores induced by transection of the SDFT, eight weeks previously. There were minimal histological differences in either the SDFT or DDFT after transection of the extensor tendons. Transection of the SDFT results in a mild, subclinical tendinopathy within the DDFT with potential implications on treatment and rehabilitation of SDFT injuries. Injury to the extensor tendons has minimal measured effect on the SDFT or DDFT.
Following injury to a tendon little is known about potential for pathology to develop in other regional tendons from overloading or altered function. The aim of this study was to investigate the gene expression and histopathological changes that occur 1) within the deep digital flexor tendon (DDFT) after injury to the superficial digital flexor tendon (SDFT) and 2) within the flexor tendons (SDFT and DDFT) after injury to the extensor tendons. Merino wethers [ Ovis aries ] (n = 18) were divided into three equal groups and underwent either partial transection of the SDFT, complete transection of the extensor tendons or were left as non-operated controls. Tendons were harvested and sampled regionally for gene expression (real time PCR) and histologic analysis eight weeks after surgery. Transection of the SDFT resulted in increased expression of collagen III, versican, biglycan, lumican and MMP1 (P<0.026 for all genes) within the DDFT. There was no effect of transecting the extensor tendons on the expression of any gene tested in either the SDFT or the DDFT. The DDFT had elevated histopathology scores induced by transection of the SDFT, eight weeks previously. There were minimal histological differences in either the SDFT or DDFT after transection of the extensor tendons. Transection of the SDFT results in a mild, subclinical tendinopathy within the DDFT with potential implications on treatment and rehabilitation of SDFT injuries. Injury to the extensor tendons has minimal measured effect on the SDFT or DDFT.
Audience Academic
Author Smith, Margaret M
Little, Christopher B
Tsang, Albert S
Jeffcott, Leo B
Biasutti, Sara A
Dart, Andrew J
AuthorAffiliation 1 Research and Clinical Training Unit, University Veterinary Teaching Hospital, Sydney School of Veterinary Science, Faculty of Science, University of Sydney, Camden, Australia
3 The Institute of Bone and Joint Research, Royal North Shore Hospital, Sydney, Australia
2 Raymond Purves Bone and Joint Research Laboratories, The Kolling Institute, Sydney Medical School, University of Sydney, Sydney, Australia
University of Pittsburgh, UNITED STATES
AuthorAffiliation_xml – name: University of Pittsburgh, UNITED STATES
– name: 2 Raymond Purves Bone and Joint Research Laboratories, The Kolling Institute, Sydney Medical School, University of Sydney, Sydney, Australia
– name: 1 Research and Clinical Training Unit, University Veterinary Teaching Hospital, Sydney School of Veterinary Science, Faculty of Science, University of Sydney, Camden, Australia
– name: 3 The Institute of Bone and Joint Research, Royal North Shore Hospital, Sydney, Australia
Author_xml – sequence: 1
  givenname: Albert S
  orcidid: 0000-0002-7697-259X
  surname: Tsang
  fullname: Tsang, Albert S
  organization: Research and Clinical Training Unit, University Veterinary Teaching Hospital, Sydney School of Veterinary Science, Faculty of Science, University of Sydney, Camden, Australia
– sequence: 2
  givenname: Andrew J
  surname: Dart
  fullname: Dart, Andrew J
  organization: Research and Clinical Training Unit, University Veterinary Teaching Hospital, Sydney School of Veterinary Science, Faculty of Science, University of Sydney, Camden, Australia
– sequence: 3
  givenname: Sara A
  surname: Biasutti
  fullname: Biasutti, Sara A
  organization: Research and Clinical Training Unit, University Veterinary Teaching Hospital, Sydney School of Veterinary Science, Faculty of Science, University of Sydney, Camden, Australia
– sequence: 4
  givenname: Leo B
  surname: Jeffcott
  fullname: Jeffcott, Leo B
  organization: Research and Clinical Training Unit, University Veterinary Teaching Hospital, Sydney School of Veterinary Science, Faculty of Science, University of Sydney, Camden, Australia
– sequence: 5
  givenname: Margaret M
  surname: Smith
  fullname: Smith, Margaret M
  organization: The Institute of Bone and Joint Research, Royal North Shore Hospital, Sydney, Australia
– sequence: 6
  givenname: Christopher B
  surname: Little
  fullname: Little, Christopher B
  organization: The Institute of Bone and Joint Research, Royal North Shore Hospital, Sydney, Australia
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31013317$$D View this record in MEDLINE/PubMed
BookMark eNqNkkuLFDEUhQsZcR76D0QCguii2zwq9XAhNMOoDQMDvrYhldxUp6lKeiqpxl74300_HKbAhdQil5vvnCS3zmV25ryDLHtJ8Jywkrxf-3FwsptvUnuOKeEVw0-yC1IzOisoZmeP6vPsMoQ1xpxVRfEsO2cEE8ZIeZH9vjEGVAzIGxTBae-Qdetx2KFUje5Qg0YDtNan005MSBCKK0Dahpi6ne2bD2ix1862dutRiKPeoTFY1yLpkN9aBwetdX4j42qHeq-he549NbIL8OK0XmU_Pt18v_4yu737vLxe3M5UkeM4o1UOrOCk0byiRtZYN5hIXdSSKVU2OWjKKkMbSQxXlBLIK66wLrmuSdM0il1ly6Ov9nItNoPt5bATXlpxaPihFXKIVnUg8loWealkEsvcmLKpeUGYrnjNsS40T14fj16bselBK3BxkN3EdLrj7Eq0fiuSbcXyMhm8PRkM_n6EEEVvg4Kukw78GER6AKtpxQqa0NdHtJXpatYZnxzVHheL9L8ZrdJUEjX_B5U-Db1VKR7Gpv5E8G4iSEyEX7GVYwhi-e3r_7N3P6fsm0fsCmQXV8F3Y0zZCVMwP4Jq8CEMYB7GR7DYp1uc0i326RandCfZq8ejfxD9jTP7Axkr-i4
CitedBy_id crossref_primary_10_1007_s11010_021_04216_z
crossref_primary_10_1089_ten_tec_2020_0032
crossref_primary_10_1089_wound_2021_0069
crossref_primary_10_1186_s13075_020_2117_2
crossref_primary_10_1021_acsbiomaterials_4c00414
crossref_primary_10_1038_s41598_021_91914_9
crossref_primary_10_1016_j_jot_2023_06_005
crossref_primary_10_1186_s12951_023_01892_5
crossref_primary_10_1186_s12951_024_02607_0
Cites_doi 10.1097/01.blo.0000092974.12414.22
10.1186/s12867-017-0089-9
10.1186/1477-7827-12-118
10.2746/042516409X391042
10.2460/javma.1993.203.03.428
10.2746/0425164044890607
10.1111/j.1751-0813.2011.00871.x
10.1002/jmor.10113
10.1136/annrheumdis-2011-200391
10.1002/jor.20347
10.1177/0363546508324283
10.1038/labinvest.2012.121
10.1371/journal.pone.0122220
10.2165/00007256-199825020-00002
10.1369/jhc.2008.952143
10.1371/journal.pone.0185282
10.1016/S0945-053X(01)00128-7
10.4061/2010/250978
10.1016/j.jbiomech.2016.06.006
10.1186/1746-6148-3-7
10.1016/S0749-0739(17)30323-1
10.1111/j.1365-2613.2007.00552.x
10.1097/00003086-199507000-00021
10.1136/ard.53.6.359
10.1016/j.joca.2010.10.010
10.2460/ajvr.2002.63.432
10.1002/art.23388
10.1007/s11259-007-0047-y
10.1016/j.joca.2011.09.007
10.1093/rheumatology/kep384
10.1111/j.2042-3306.2011.00471.x
10.1111/j.2042-3306.2011.00514.x
10.1083/jcb.151.4.779
10.1111/iep.12027
10.1111/j.1600-0838.2005.00456.x
10.1016/S0737-0806(07)80424-2
10.2746/042516401776254808
10.2746/042516407X159132
10.1177/0363546508331137
10.1111/j.2042-3306.1991.tb03754.x
10.2746/042516409X480395
10.1002/art.21672
10.2460/ajvr.1991.52.08.1376
10.18849/ve.v2i1.50
10.2460/ajvr.69.7.928
10.1073/pnas.1507387112
10.1136/bjsports-2011-090342
10.1038/414895a
10.1093/rheumatology/kei152
10.1002/jor.23251
10.2746/0425164044890580
10.1371/journal.pone.0123691
ContentType Journal Article
Copyright COPYRIGHT 2019 Public Library of Science
2019 Tsang et al 2019 Tsang et al
Copyright_xml – notice: COPYRIGHT 2019 Public Library of Science
– notice: 2019 Tsang et al 2019 Tsang et al
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
IOV
ISR
7X8
5PM
DOA
DOI 10.1371/journal.pone.0215830
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
Gale In Context: Opposing Viewpoints
Gale In Context: Science
MEDLINE - Academic
PubMed Central (Full Participant titles)
Directory of Open Access Journals
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
MEDLINE - Academic
DatabaseTitleList MEDLINE




Database_xml – sequence: 1
  dbid: DOA
  name: Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Sciences (General)
DocumentTitleAlternate Effects of tendon injury on uninjured regional tendons
EISSN 1932-6203
Editor Wang, James H-C
Editor_xml – sequence: 1
  givenname: James H-C
  surname: Wang
  fullname: Wang, James H-C
EndPage e0215830
ExternalDocumentID oai_doaj_org_article_49a647ca75da4ff7b95613d85950d6d5
A583328651
10_1371_journal_pone_0215830
31013317
Genre Journal Article
GeographicLocations Australia
GeographicLocations_xml – name: Australia
GroupedDBID ---
123
29O
2WC
3V.
53G
5VS
7RV
7X2
7X7
7XC
88E
8AO
8C1
8CJ
8FE
8FG
8FH
8FI
8FJ
A8Z
AAFWJ
ABDBF
ABIVO
ABJCF
ABUWG
ACGFO
ACIHN
ACIWK
ACPRK
ADBBV
ADRAZ
AEAQA
AENEX
AFKRA
AFRAH
AHMBA
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
APEBS
ARAPS
ATCPS
BAWUL
BBNVY
BBORY
BCNDV
BENPR
BGLVJ
BHPHI
BKEYQ
BPHCQ
BVXVI
BWKFM
CCPQU
CGR
CS3
CUY
CVF
D1I
D1J
D1K
DIK
DU5
E3Z
EAP
EAS
EBD
ECM
EIF
EMOBN
ESTFP
ESX
EX3
F5P
FPL
FYUFA
GROUPED_DOAJ
GX1
HCIFZ
HH5
HMCUK
HYE
IAO
IEA
IHR
IHW
INH
INR
IOV
IPNFZ
IPY
ISE
ISR
ITC
K6-
KB.
KQ8
L6V
LK5
LK8
M0K
M1P
M48
M7P
M7R
M7S
M~E
NAPCQ
NPM
O5R
O5S
OK1
P2P
P62
PATMY
PDBOC
PIMPY
PQQKQ
PROAC
PSQYO
PTHSS
PV9
PYCSY
RIG
RNS
RPM
RZL
SV3
TR2
UKHRP
WOQ
WOW
~02
~KM
AAYXX
CITATION
AFPKN
7X8
5PM
ID FETCH-LOGICAL-c640t-284e3651bd582fa90db01ad69a3cc7b4ed238f2ba1f5c221e485c0d75d91bbbc3
IEDL.DBID RPM
ISSN 1932-6203
IngestDate Tue Oct 22 15:00:28 EDT 2024
Tue Sep 17 21:11:41 EDT 2024
Fri Oct 25 00:06:53 EDT 2024
Tue Nov 19 21:03:47 EST 2024
Tue Nov 12 22:47:24 EST 2024
Thu Aug 01 20:17:32 EDT 2024
Thu Aug 01 20:15:18 EDT 2024
Tue Aug 20 22:13:18 EDT 2024
Fri Nov 22 03:20:24 EST 2024
Wed Oct 16 00:46:01 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 4
Language English
License This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c640t-284e3651bd582fa90db01ad69a3cc7b4ed238f2ba1f5c221e485c0d75d91bbbc3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Competing Interests: The authors have declared that no competing interests exist.
These authors also contributed equally to this work.
ORCID 0000-0002-7697-259X
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478347/
PMID 31013317
PQID 2213928362
PQPubID 23479
PageCount e0215830
ParticipantIDs doaj_primary_oai_doaj_org_article_49a647ca75da4ff7b95613d85950d6d5
pubmedcentral_primary_oai_pubmedcentral_nih_gov_6478347
proquest_miscellaneous_2213928362
gale_infotracmisc_A583328651
gale_infotracacademiconefile_A583328651
gale_incontextgauss_ISR_A583328651
gale_incontextgauss_IOV_A583328651
gale_healthsolutions_A583328651
crossref_primary_10_1371_journal_pone_0215830
pubmed_primary_31013317
PublicationCentury 2000
PublicationDate 2019-04-23
PublicationDateYYYYMMDD 2019-04-23
PublicationDate_xml – month: 04
  year: 2019
  text: 2019-04-23
  day: 23
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: San Francisco, CA USA
PublicationTitle PloS one
PublicationTitleAlternate PLoS One
PublicationYear 2019
Publisher Public Library of Science
Public Library of Science (PLoS)
Publisher_xml – name: Public Library of Science
– name: Public Library of Science (PLoS)
References Y Zhang (ref35) 2015; 10
PPY Lui (ref47) 2010; 49
GM Baxter (ref60) 1987
JH Yoon (ref50) 2005; 5
JK Belknap (ref57) 1993; 203
AE Watts (ref22) 2011; 44
NA Brown (ref21) 2003; 258
RK Choi (ref54) 2016; 49
CT Thorpe (ref51) 2013; 94
ER Ely (ref10) 2004; 36
A Changoor (ref31) 2011; 19
GC Jones (ref62) 2006; 54
JM Archambault (ref42) 2007; 25
M Astrom (ref16) 1995; 316
JS Jorgensen (ref63) 2003
A Changoor (ref32) 2011; 19
JM Archambault (ref61) 2007; 25
T Hashimoto (ref17) 2003; 415
CS Avella (ref55) 2009; 41
LS Meershoek (ref44) 2002; 63
N Jansson (ref58) 1995; 15
A Crovace (ref25) 2007; 31
CJ Caniglia (ref24) 2012; 44
CRB Elliott (ref7) 2012; 90
HL Birch (ref19) 2007; 88
KM Dyce (ref30) 2009
D Ireland (ref46) 2001; 20
MM Smith (ref29) 2008; 58
AN Corps (ref34) 2006; 45
JD Rees (ref15) 2009; 37
A Veres-Székely (ref36) 2017; 18
Y Ezura (ref49) 2000; 151
A Crovace (ref28) 2010; 2010
VS Baddela (ref37) 2014; 12
RB Williams (ref4) 2001; 33
RD McCurdy (ref33) 2008
KH Lam (ref9) 2007; 39
GP Riley (ref45) 2005; 15
AN Corps (ref43) 2012; 71
GP Riley (ref48) 1994; 53
CT Thorpe (ref11) 2010; 42
PPY Lui (ref40) 2009; 57
JW Foland (ref59) 1991; 23
T Hashimoto (ref39) 2003; 415
S Biasutti (ref1) 2017; 12
SS Durgam (ref26) 2016; 34
M de Mos (ref41) 2009; 37
AM Wilson (ref20) 2001; 414
S Durgam (ref23) 2017; 2
IA Silver (ref12) 1983; 15
AL Bertone (ref56) 1995; 11
AJ Nixon (ref27) 2008; 69
J Leppilahti (ref2) 1998; 25
D Ayers (ref38) 2007; 3
D Pilling (ref53) 2015; 112
RB Bigbie (ref6) 1991; 52
LR Bramlage (ref13) 1986
P Sharma (ref14) 2006; 6
DS Mills (ref5) 1999
Y Kasashima (ref8) 2004; 36
A Krishnan (ref52) 2012; 92
S de Jonge (ref3) 2011; 45
E Jacobson (ref18) 2015; 10
References_xml – volume: 415
  start-page: 111
  year: 2003
  ident: ref17
  article-title: Pathologic evidence of degeneration as a primary cause of rotator cuff tear
  publication-title: Clin Orthop Relat Res
  doi: 10.1097/01.blo.0000092974.12414.22
  contributor:
    fullname: T Hashimoto
– volume: 18
  start-page: 12
  year: 2017
  ident: ref36
  article-title: Selective measurement of α smooth muscle actin: why β-actin can not be used as a housekeeping gene when tissue fibrosis occurs
  publication-title: BMC Mol Biol
  doi: 10.1186/s12867-017-0089-9
  contributor:
    fullname: A Veres-Székely
– volume: 12
  start-page: 118
  year: 2014
  ident: ref37
  article-title: Suitable housekeeping genes for normalization of transcript abundance analysis by real-time RT-PCR in cultured bovine granulosa cells during hypoxia and differential cell plating density
  publication-title: Reprod Biol Enocrinol
  doi: 10.1186/1477-7827-12-118
  contributor:
    fullname: VS Baddela
– volume: 41
  start-page: 449
  year: 2009
  ident: ref55
  article-title: Ultrasonographic assessment of the superficial digital flexor tendons of National Hunt racehorses in training over two racing seasons
  publication-title: Equine Vet J
  doi: 10.2746/042516409X391042
  contributor:
    fullname: CS Avella
– volume: 203
  start-page: 428
  year: 1993
  ident: ref57
  article-title: Extensor tendon lacerations in horses: 50 cases (1982–1988)
  publication-title: J Am Vet Med Assoc
  doi: 10.2460/javma.1993.203.03.428
  contributor:
    fullname: JK Belknap
– volume: 36
  start-page: 365
  year: 2004
  ident: ref10
  article-title: Fractures and tendon injuries in National Hunt horses in training in the UK: A pilot study
  publication-title: Equine Vet J
  doi: 10.2746/0425164044890607
  contributor:
    fullname: ER Ely
– volume: 90
  start-page: 20
  issue: 1–2
  year: 2012
  ident: ref7
  article-title: Transection of the lateral and long digital extensor tendons in racehorses
  publication-title: Aust Vet J
  doi: 10.1111/j.1751-0813.2011.00871.x
  contributor:
    fullname: CRB Elliott
– start-page: 1215
  year: 2008
  ident: ref33
  article-title: Validation of the comparative quantification method of real- time PCR analysis and a cautionary tale of housekeeping gene selection
  publication-title: Gene Ther Mol Biol
  contributor:
    fullname: RD McCurdy
– volume: 258
  start-page: 106
  issue: 1
  year: 2003
  ident: ref21
  article-title: Architectural properties of distal forelimb muscles in horses, Equus caballus
  publication-title: J Morphol
  doi: 10.1002/jmor.10113
  contributor:
    fullname: NA Brown
– volume: 71
  start-page: 746
  year: 2012
  ident: ref43
  article-title: Changes in matrix protein biochemistry and the expression of mRNA encoding matrix proteins and metalloproteinases in posterior tibialis tendinopathy
  publication-title: Ann Rheum Dis
  doi: 10.1136/annrheumdis-2011-200391
  contributor:
    fullname: AN Corps
– volume: 25
  start-page: 617
  year: 2007
  ident: ref61
  article-title: Rat supraspinatus tendon expresses cartilage markers with overuse
  publication-title: J Orthop Res
  doi: 10.1002/jor.20347
  contributor:
    fullname: JM Archambault
– start-page: 628
  year: 2003
  ident: ref63
  article-title: Diagnosis and Management of Lameness in the Horse
  contributor:
    fullname: JS Jorgensen
– volume: 37
  start-page: 1855
  year: 2009
  ident: ref15
  article-title: Management of Tendinopathy
  publication-title: Am J Sports Med
  doi: 10.1177/0363546508324283
  contributor:
    fullname: JD Rees
– volume: 92
  start-page: 1712
  issue: 12
  year: 2012
  ident: ref52
  article-title: Lumican, an extracellular matrix proteoglycan, is a novel requisite for hepatic fibrosis
  publication-title: Lab Invest
  doi: 10.1038/labinvest.2012.121
  contributor:
    fullname: A Krishnan
– volume: 10
  start-page: e0122220
  issue: 4
  year: 2015
  ident: ref18
  article-title: Focal experimental injury leads to widespread gene expression and histologic changes in equine flexor tendons
  publication-title: Plos One
  doi: 10.1371/journal.pone.0122220
  contributor:
    fullname: E Jacobson
– start-page: 715
  year: 1987
  ident: ref60
  article-title: Retrospective study of lower limb wounds involving tendons, tendon sheaths or joints in horses
  contributor:
    fullname: GM Baxter
– volume: 25
  start-page: 79
  year: 1998
  ident: ref2
  article-title: Total Achilles tendon rupture: A review
  publication-title: Sports Med
  doi: 10.2165/00007256-199825020-00002
  contributor:
    fullname: J Leppilahti
– volume: 57
  start-page: 91
  year: 2009
  ident: ref40
  article-title: Chondrocyte phenotype and ectopic ossification in collagenase-induced tendon degeneration
  publication-title: J Histochem Cytochem
  doi: 10.1369/jhc.2008.952143
  contributor:
    fullname: PPY Lui
– year: 2009
  ident: ref30
  article-title: Textbook of Veterinary Anatomy
  contributor:
    fullname: KM Dyce
– volume: 15
  start-page: S1
  year: 1983
  ident: ref12
  article-title: A clinical and experimental study of tendon injury, healing and treatment in the horse
  publication-title: Equine Vet J
  contributor:
    fullname: IA Silver
– volume: 12
  start-page: e0185282
  issue: 10
  year: 2017
  ident: ref1
  article-title: Spatiotemporal variations in gene expression, histology and biomechanics in an ovine model of tendinopathy
  publication-title: Plos One
  doi: 10.1371/journal.pone.0185282
  contributor:
    fullname: S Biasutti
– volume: 5
  start-page: 22
  year: 2005
  ident: ref50
  article-title: Tendon proteoglycans: biochemistry and function
  publication-title: J Musculoskelet. Neuronal Interact
  contributor:
    fullname: JH Yoon
– volume: 20
  start-page: 159
  year: 2001
  ident: ref46
  article-title: Multiple changes in gene expression in chronic human Achilles tendinopathy
  publication-title: Matrix Biol
  doi: 10.1016/S0945-053X(01)00128-7
  contributor:
    fullname: D Ireland
– volume: 2010
  start-page: 250978
  year: 2010
  ident: ref28
  article-title: Histological and immunohistochemical evaluation of autologous cultured bone marrow mesenchymal stem cells and bone marrow mononucleated cells in collagenase-induced tendinitis of equine superficial digital flexor tendon
  publication-title: Vet Med Int
  doi: 10.4061/2010/250978
  contributor:
    fullname: A Crovace
– year: 1999
  ident: ref5
  article-title: Equine Behaviour: Principles and Practice
  contributor:
    fullname: DS Mills
– volume: 49
  start-page: 2694
  issue: 13
  year: 2016
  ident: ref54
  article-title: Chondroitin sulphate glycosaminoglycans contribute to widespread inferior biomechanics in tendon after focal injury
  publication-title: J Biomech
  doi: 10.1016/j.jbiomech.2016.06.006
  contributor:
    fullname: RK Choi
– volume: 3
  start-page: 7
  year: 2007
  ident: ref38
  article-title: Expression stability of commonly used reference genes in canine articular connective tissues
  publication-title: BMC Vet Res
  doi: 10.1186/1746-6148-3-7
  contributor:
    fullname: D Ayers
– volume: 11
  start-page: 293
  year: 1995
  ident: ref56
  article-title: Tendon lacerations
  publication-title: Vet Clin North Am Equine Pract
  doi: 10.1016/S0749-0739(17)30323-1
  contributor:
    fullname: AL Bertone
– volume: 88
  start-page: 241
  issue: 4
  year: 2007
  ident: ref19
  article-title: Tendon matrix composition and turnover in relation to functional requirements
  publication-title: Int J Exp Pathol
  doi: 10.1111/j.1365-2613.2007.00552.x
  contributor:
    fullname: HL Birch
– volume: 316
  start-page: 151
  year: 1995
  ident: ref16
  article-title: Chronic Achilles tendinopathy—a survey of surgical and histopathologic findings
  publication-title: Clin Orthop Relat Res
  doi: 10.1097/00003086-199507000-00021
  contributor:
    fullname: M Astrom
– volume: 6
  start-page: 181
  year: 2006
  ident: ref14
  article-title: Biology of tendon injury: healing, modeling and remodeling
  publication-title: J Musculoskelet Neuronal Interact
  contributor:
    fullname: P Sharma
– volume: 53
  start-page: 359
  year: 1994
  ident: ref48
  article-title: Tendon degeneration and chronic shoulder pain–changes in the collagen composition of the human rotator cuff tendons in rotator cuff tendinitis
  publication-title: Ann Rheumatic Dis
  doi: 10.1136/ard.53.6.359
  contributor:
    fullname: GP Riley
– volume: 415
  start-page: 111
  year: 2003
  ident: ref39
  article-title: Pathologic evidence of degeneration as a primary cause of rotator cuff tear
  publication-title: Clin Orthop Relat Res
  doi: 10.1097/01.blo.0000092974.12414.22
  contributor:
    fullname: T Hashimoto
– volume: 19
  start-page: 126
  year: 2011
  ident: ref31
  article-title: A polarized light microscopy method for accurate and reliable grading of collagen organization in cartilage repair
  publication-title: Osteoarthritis cartilage
  doi: 10.1016/j.joca.2010.10.010
  contributor:
    fullname: A Changoor
– volume: 63
  start-page: 432
  issue: 3
  year: 2002
  ident: ref44
  article-title: Calculated forelimb flexor tendon forces in horses with experimentally induced superficial digital flexor tendinitis and the effects of application of heel wedges
  publication-title: Am J Vet Res
  doi: 10.2460/ajvr.2002.63.432
  contributor:
    fullname: LS Meershoek
– volume: 58
  start-page: 1055
  year: 2008
  ident: ref29
  article-title: Modulation of aggrecan and ADAMTS expression in ovine tendinopathy induced by altered strain
  publication-title: Arthritis Rheum
  doi: 10.1002/art.23388
  contributor:
    fullname: MM Smith
– volume: 31
  start-page: 281
  issue: Suppl. 1
  year: 2007
  ident: ref25
  article-title: Cell therapy for tendon repair in horses: An experimental study
  publication-title: Vet Res Commun
  doi: 10.1007/s11259-007-0047-y
  contributor:
    fullname: A Crovace
– volume: 19
  start-page: 1458
  year: 2011
  ident: ref32
  article-title: Structural characteristics of the collagen network in human normal, degraded and repair articular cartilages observed in polarized light and scanning electron microscopies
  publication-title: Osteoarthritis Cartilage
  doi: 10.1016/j.joca.2011.09.007
  contributor:
    fullname: A Changoor
– volume: 49
  start-page: 231
  year: 2010
  ident: ref47
  article-title: Sustained expression of proteoglycans and collagen type III/type I ratio in a calcified tendinopathy model
  publication-title: Rheumatology
  doi: 10.1093/rheumatology/kep384
  contributor:
    fullname: PPY Lui
– volume: 44
  start-page: 576
  year: 2011
  ident: ref22
  article-title: A collagenase gel/physical defect model for controlled induction of superficial digital flexor tendonitis
  publication-title: Equine Vet J
  doi: 10.1111/j.2042-3306.2011.00471.x
  contributor:
    fullname: AE Watts
– volume: 44
  start-page: 587
  year: 2012
  ident: ref24
  article-title: The effect of intralesional injection of bone marrow derived mesenchymal stem cells and bone marrow supernatant on collagen fibril size in a surgical model of equine superficial digital flexor tendonitis
  publication-title: Equine Vet J
  doi: 10.1111/j.2042-3306.2011.00514.x
  contributor:
    fullname: CJ Caniglia
– volume: 25
  start-page: 617
  year: 2007
  ident: ref42
  article-title: Rat supraspinatus tendon expresses cartilage markers with overuse
  publication-title: J Orthop Res
  doi: 10.1002/jor.20347
  contributor:
    fullname: JM Archambault
– volume: 151
  start-page: 779
  year: 2000
  ident: ref49
  article-title: Differential expression of lumican and fibromodulin regulate collagen fibrillogenesis in developing mouse tendons
  publication-title: J Cell Bio
  doi: 10.1083/jcb.151.4.779
  contributor:
    fullname: Y Ezura
– volume: 94
  start-page: 248
  issue: 4
  year: 2013
  ident: ref51
  article-title: The role of the non-collagenous matrix in tendon function
  publication-title: Int J Exp Pathol
  doi: 10.1111/iep.12027
  contributor:
    fullname: CT Thorpe
– volume: 15
  start-page: 241
  issue: 4
  year: 2005
  ident: ref45
  article-title: Gene expression and matrix turnover in overused and damaged tendons
  publication-title: Scand J Med Sci Sports
  doi: 10.1111/j.1600-0838.2005.00456.x
  contributor:
    fullname: GP Riley
– start-page: 365
  year: 1986
  ident: ref13
  article-title: Superior check ligament desmotomy as a treatment for superficial digital flexor tendonitis: initial report
  contributor:
    fullname: LR Bramlage
– volume: 15
  start-page: 537
  year: 1995
  ident: ref58
  article-title: Digital extensor tendon lacerations in horses: a retrospective evaluation of 22 cases
  publication-title: J Equine Vet Sci
  doi: 10.1016/S0737-0806(07)80424-2
  contributor:
    fullname: N Jansson
– volume: 33
  start-page: 478
  year: 2001
  ident: ref4
  article-title: Racehorse injuries, clinical problems and fatalities recorded on British racecourses from flat racing and National Hunt racing during 1996, 1997 and 1998
  publication-title: Equine Vet J
  doi: 10.2746/042516401776254808
  contributor:
    fullname: RB Williams
– volume: 39
  start-page: 143
  year: 2007
  ident: ref9
  article-title: Descriptive analysis of retirement of Thoroughbred racehorses due to tendon injuries at the Hong Kong Jockey Club (1992–2004)
  publication-title: Equine Vet J
  doi: 10.2746/042516407X159132
  contributor:
    fullname: KH Lam
– volume: 37
  start-page: 1214
  year: 2009
  ident: ref41
  article-title: In vitro model to study chondrogenic differentiation in tendinopathy
  publication-title: Am J Sports Med
  doi: 10.1177/0363546508331137
  contributor:
    fullname: M de Mos
– volume: 23
  start-page: 422
  year: 1991
  ident: ref59
  article-title: Traumatic injuries involving tendons of the distal limbs in horses: a retrospective study of 55 cases
  publication-title: Equine Vet J
  doi: 10.1111/j.2042-3306.1991.tb03754.x
  contributor:
    fullname: JW Foland
– volume: 42
  start-page: 174
  year: 2010
  ident: ref11
  article-title: A review of tendon injury: Why is the equine superficial digital flexor tendon most at risk?
  publication-title: Equine Vet J
  doi: 10.2746/042516409X480395
  contributor:
    fullname: CT Thorpe
– volume: 54
  start-page: 832
  year: 2006
  ident: ref62
  article-title: Expression profiling of metalloproteinases and tissue inhibitors of metalloproteinases in normal and degenerate human Achilles tendon
  publication-title: Arthritis Rheum
  doi: 10.1002/art.21672
  contributor:
    fullname: GC Jones
– volume: 52
  start-page: 1376
  year: 1991
  ident: ref6
  article-title: Purohit Rc, Wright JC. Effects of amnion and live yeast-cell derivative on second-intention healing in horses
  publication-title: Am J Vet Res
  doi: 10.2460/ajvr.1991.52.08.1376
  contributor:
    fullname: RB Bigbie
– volume: 2
  issue: 1
  year: 2017
  ident: ref23
  article-title: Evidence supporting intralesional stem cell therapy to improve equine flexor tendon healing
  publication-title: Veterinary Evidence
  doi: 10.18849/ve.v2i1.50
  contributor:
    fullname: S Durgam
– volume: 69
  start-page: 928
  issue: 7
  year: 2008
  ident: ref27
  article-title: Effect of adipose-derived nucleated cell fractions on tendon repair in horses with collagenase-induced tendinitis
  publication-title: Am J Vet Res
  doi: 10.2460/ajvr.69.7.928
  contributor:
    fullname: AJ Nixon
– volume: 112
  start-page: 11929
  issue: 38
  year: 2015
  ident: ref53
  article-title: TNF-α–stimulated fibroblasts secrete lumican to promote fibrocyte differentiation
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1507387112
  contributor:
    fullname: D Pilling
– volume: 45
  start-page: 1026
  year: 2011
  ident: ref3
  article-title: Incidence of midportion Achilles tendinopathy in the general population
  publication-title: Brit J Sport Med
  doi: 10.1136/bjsports-2011-090342
  contributor:
    fullname: S de Jonge
– volume: 414
  start-page: 895
  issue: 6866
  year: 2001
  ident: ref20
  article-title: Horses damp the spring in their step
  publication-title: Nature
  doi: 10.1038/414895a
  contributor:
    fullname: AM Wilson
– volume: 45
  start-page: 291
  issue: 3
  year: 2006
  ident: ref34
  article-title: Increased expression of aggrecan and biglycan mRNA in Achilles tendinopathy
  publication-title: Rheumatology (Oxford)
  doi: 10.1093/rheumatology/kei152
  contributor:
    fullname: AN Corps
– volume: 34
  start-page: 2162
  issue: 12
  year: 2016
  ident: ref26
  article-title: Tendon‐derived progenitor cells improve healing of collagenase‐induced flexor tendinitis
  publication-title: J Orthop Res
  doi: 10.1002/jor.23251
  contributor:
    fullname: SS Durgam
– volume: 36
  start-page: 346
  year: 2004
  ident: ref8
  article-title: Prevalence of superficial digital flexor tendonitis and suspensory desmitis in Japanese Thoroughbred flat racehorses in 1999
  publication-title: Equine Vet J
  doi: 10.2746/0425164044890580
  contributor:
    fullname: Y Kasashima
– volume: 10
  start-page: e0123691
  issue: 5
  year: 2015
  ident: ref35
  article-title: Do housekeeping genes exist?
  publication-title: Plos One
  doi: 10.1371/journal.pone.0123691
  contributor:
    fullname: Y Zhang
SSID ssj0053866
Score 2.403453
Snippet Following injury to a tendon little is known about potential for pathology to develop in other regional tendons from overloading or altered function. The aim...
SourceID doaj
pubmedcentral
proquest
gale
crossref
pubmed
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
StartPage e0215830
SubjectTerms Animals
Biochemistry
Collagen
Collagen - genetics
Development and progression
Disease Models, Animal
Extremities - physiopathology
Gene expression
Gene Expression Regulation - genetics
Genes
Genetic testing
Histochemistry
Humans
Polymerase chain reaction
Sheep
Sheep, Domestic - genetics
Sports injuries
Surgery
Tendinopathy - genetics
Tendinopathy - physiopathology
Tendon injuries
Tendon Injuries - genetics
Tendon Injuries - physiopathology
Tendons - metabolism
Tendons - physiopathology
SummonAdditionalLinks – databaseName: Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZQT1wQ5RkoYBAScEgbx0mccFsQVUECJKCoN8uvtEHFqchuJQ78d2Zs72ojDnDgFsUTKZkZZz7bM98Q8hTPporK9bluHSxQtNW5YoWCNY8wpWor2zrcGnj_oTk6rt6d1Cdbrb4wJyzSA0fFHVSdaiphlKitqvpeaKzE5BZpuQrb2MheWpTrxVT8B8MsbppUKMcFO0h22b8YvdvHKNdi1vNWIAp8_X_-lbfC0jxlcisGHV4n1xJ4pIv40rvkivM3yG6anhN9njikX9wkvyIr8UTHnuIu9-jp4L-B_ihcrXy4dpZiWwaE4klmAiEKiJBaRJXn9Hz4rl_SBT6bXw6XIw1ktBRz5U-p8hR3I1x4dvAj9jb-SUNnnVvk-PDNl9dHeeq0kJumKpY5xCjHm5ppW7dlr7rC6oIp23SKGyN05SxE9r7UivW1KUvmqrY2hQWbdExrbfhtsuNBt3cJrblrtWo1wKweqWo6wYVCihgAdqw0LiP5Wu3yIhJqyHCqJmAhEtUo0UwymSkjr9A2G1mkww43wElkchL5NyfJyCO0rIy1pZtJLRdYc4a1uSwjT4IEUmJ4zLk5Vatpkm8_fv0Hoc-fZkLPklA_gqsYleoc4JuQamsmuTeThIltZsOP134ocQiz4bwbV5MECwCsbQF7ZORO9MuNfgCuMw6gMCNi5rEzBc5H_HAWeMWx7JhX4t7_0Ph9chWgZTh3K_ke2Vn-WLkHAN-W-mGYqb8BaMFFeA
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: Scholars Portal Open Access Journals
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Lb9NAEF5V5cIFUZ4uBRaEBBwc-bH22kgIBURVkAoSENTbal8ORmFd4qSiB_47M-tNVAuQerOys0o8j8y3j_mGkCd4NpUw28SqsrBAUUbFMk0krHm4zmTFTGVxa-D4Q3k0Y-9PipMdsunZGhTY_3Nph_2kZsvF5NfP81cQ8C991waebiZNTjtnJ5jDqhwW8VcyyI14yeuYbc8VILrLMhTQ_W_mKEF5Hv-__60vpKvxVcoLuenwOrkWQCWdDl6wR3asu0H2Qtj29Fngln5-k_we2Ip72jUUd787R1v3HfRK4Wnt_LM1FNs1IEQPMj0IUUCK1CDaXNBF-0O9oFOcG5-1Zx31JLUU79DPqXQUdymsn9u6Dnsen1PfcecWmR2-_fLmKA4dGGJdsmQVQ-6yeVmkyhRV1sg6MSpJpSlrmWvNFbMGMn6TKZk2hc6y1LKq0InhhalTpZTOb5NdB7q9S2iR20rJSgH8apDCpuY5l0gdA4AvzbSNSLxRuzgdiDaEP23jsEAZ1CjQTCKYKSKv0TZbWaTJ9h90y7kIUSdYLUvGtYQfJFnTcIVlvLlBTrfElKaIyEO0rBhqTrfBLqZYi4Y1u2lEHnsJpMpweBdnLtd9L959_HoJoc-fRkJPg1DTgatoGeof4J2QgmskeTCShIDXo-FHGz8UOIS35Jzt1r0ACwDcrQCTROTO4Jdb_QCMT3MAixHhI48dKXA84tpvnm8cy5Fzxvcv8b33yFVAlP64LcsPyO5qubb3AbWt1AMfiH8ABsdE9A
  priority: 102
  providerName: Scholars Portal
Title Effects of tendon injury on uninjured regional tendons in the distal limb: An in-vivo study using an ovine tendinopathy model
URI https://www.ncbi.nlm.nih.gov/pubmed/31013317
https://search.proquest.com/docview/2213928362
https://pubmed.ncbi.nlm.nih.gov/PMC6478347
https://doaj.org/article/49a647ca75da4ff7b95613d85950d6d5
Volume 14
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9NAEF615cIFUZ6GEhaEBByc-P3glkYNBSmlKhTlZu3LqVGyjuqkEgf-OzPrdajFBXFZWdlZyZmHZ3Z35htC3uDdlBep0uWZgg0Kl9xlvsdgz5OKgGWRzBQeDczOktPL6PM8nu-RuKuFMUn7gldDvVwNdXVlcivXKzHq8sRG57MJ1keGUTraJ_vgfrstevv5BQNOElsjF6b-yIpkuK61GqKDy0Ls_gZRDezOTJuyP-7IoPb__W2-5Zz6iZO3PNH0PrlnQ0g6bl_1kOwp_YAcWiNt6DuLJP3-IfnVYhM3tC4pnnXXmlb6B3CRwtNWm2clKTZnwIDc0jRARCEupBJjyyVdViv-gY5xrXtT3dTUQNJSzJhfUKYpnkkos7bSNXY4_klNf51H5HJ68m1y6tp-C65IIm_jgqdSYRL7XMZZULLck9zzmUxyFgqR8khJ8O9lwJlfxiIIfBVlsfBkGsvc55yL8DE50MDmp4TGoco4yzgEWyUC1uRpmDIEioHwzg-Ecojbsb1Yt7AahblbS2E70rKxQIkVVmIOOUbZ7GgRFNv8UF8vCqsaRZQz0AzB4IVYVJYpx6LdUCKCmycTGTvkJUq2aCtMd6ZdjLHyDCt0fYe8NhQIjKEx82bBtk1TfPry_R-Ivl70iN5aorIGVRHMVjvAf0LArR7lUY8SzFv0pl91eljgFObEaVVvmwIkAMFtBhGIQ560ernjT6feDkl7GttjYH8GjM2gi1vjevbfK5-TuxBVmiu3IDwiB5vrrXoBkduGD8Be5ymM2cTHcfpxQO4cn5ydXwzMWQiMsygbGHv-DTQJTBg
link.rule.ids 230,314,727,780,784,864,885,2102,2221,24318,27924,27925,31720,33267,33374,33745,53791,53793
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9NAEF6VcoALorxqKHRBSMDBid8PbqGiSqEpCFrU22pfDkbJuqqTShz478ys16EWF8TNys5Kzjw8M7sz3xDyEu-mgkRXvig0JChCCZ-HAYecJ5cRLxJVaDwamJ1k07Pkw3l6vkXSvhfGFu1LUY_MYjky9XdbW3mxlOO-Tmz8eXaA_ZFxko9vkJtpnJdhn6R3H2Aw4SxzXXJxHo6dUEYXjdEjdHFFjPPfIK6B_MwOKvvjkCxu_99f52vuaVg6ec0XHd4ld1wQSSfdy-6QLW3ukR1npi197bCk39wnvzp04pY2FcXT7sbQ2vwAPlJ4Whv7rBXF8QwYkjuaFogoRIZUYXS5oIt6Kd7SCe71r-qrhlpQWoo183PKDcVTCW331qbBGcc_qZ2w84CcHb4_PZj6buKCL7MkWPngq3ScpaFQaRFVvAyUCEKuspLHUuYi0Qo8fBUJHlapjKJQJ0UqA5WnqgyFEDJ-SLYNsHmX0DTWheCFgHCrQsiaMo9zjlAxEOCFkdQe8Xu2s4sOWIPZ27UcEpKOjQwlxpzEPPIOZbOhRVhs-0NzOWdOOVhSctANyeGFeFJVucC23VghhlugMpV6ZB8ly7oe041xswn2nmGPbuiRF5YCoTEM1t7M-bpt2dGnb_9A9PXLgOiVI6oaUBXJXb8D_CeE3BpQ7g0owcDlYPl5r4cMl7Aqzuhm3TKQAIS3BcQgHnnU6eWGP716eyQfaOyAgcMVMDeLL-7M6_F_79wnt6ans2N2fHTy8Qm5DTGmvYCL4j2yvbpc66cQx63EM2u1vwGbZklq
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9NAEF5BkRAXRHkaCl0QEnBwYnv9CrdQiFqgpQKKelvty8EoWUd1UokD_52Z9SbE4oK4WdlZyZmHZ2Z35htCnuPdVJSaKpSlgQRFahmKOBKQ8xQqEWWqS4NHA8cn-eFZ-v48O98a9eWK9pWsB3Y2H9j6u6utXMzVcF0nNjw9PsD-SJYWw4WuhlfJtYyBkq0T9e4jDGac575TjhXx0AtmsGisGaCbKxnOgIPYBnI0N6zsj1Ny2P1_f6G3XFS_fHLLH01ukZs-kKTj7oV3yRVjb5Ndb6otfenxpF_dIb86hOKWNhXFE-_G0tr-AF5SeFpZ92w0xRENGJZ7mhaIKESHVGOEOaOzei5f0zHuDS_ry4Y6YFqKdfNTKizFkwnj9ta2wTnHP6mbsnOXnE3efT04DP3UhVDlabQMwV8Zlmex1FmZVGIUaRnFQucjwZQqZGo0ePkqkSKuMpUksUnLTEW6yPQollIqdo_sWGDzA0IzZkopSgkhV4WwNaOCFQLhYiDIixNlAhKu2c4XHbgGdzdsBSQlHRs5Sox7iQXkDcpmQ4vQ2O6H5mLKvYLwdCRAP5SAFxJpVRUSW3eZRhy3SOc6C8g-SpZ3faYbA-dj7D_DPt04IM8cBcJjWKy_mYpV2_KjT9_-gejL5x7RC09UNaAqSvieB_hPCLvVo9zrUYKRq97y07UeclzCyjhrmlXLQQIQ4pYQhwTkfqeXG_6s1TsgRU9jewzsr4DJOYxxb2IP_3vnPrl--nbCPx6dfHhEbkCY6e7gErZHdpYXK_MYQrmlfOKM9jcxYUp9
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Effects+of+tendon+injury+on+uninjured+regional+tendons+in+the+distal+limb%3A+An+in-vivo+study+using+an+ovine+tendinopathy+model&rft.jtitle=PloS+one&rft.au=Tsang%2C+Albert+S&rft.au=Dart%2C+Andrew+J&rft.au=Biasutti%2C+Sara+A&rft.au=Jeffcott%2C+Leo+B&rft.date=2019-04-23&rft.eissn=1932-6203&rft.volume=14&rft.issue=4&rft.spage=e0215830&rft.epage=e0215830&rft_id=info:doi/10.1371%2Fjournal.pone.0215830&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon