Diversity of class 1 integron gene cassette Pc promoter variants in clinical Escherichia coli strains and description of a new P2 promoter variant

• Published in: International journal of antimicrobial agents Vol. 38; no. 6; pp. 526 - 529
• Main Authors: Vinué, Laura, Jové, Thomas, Torres, Carmen, Ploy, Marie-Cécile
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.12.2011; Elsevier
• Subjects: Antibiotic resistance; Antibiotics. Antiinfectious agents. Antiparasitic agents; Bacteriology; Biological and medical sciences; Escherichia coli; Escherichia coli - genetics; Escherichia coli - isolation & purification; Escherichia coli Infections; Escherichia coli Infections - epidemiology; Escherichia coli Infections - microbiology; Escherichia coli Proteins; Escherichia coli Proteins - genetics; France; France - epidemiology; genes; Genetic Variation; Human health and pathology; Humans; Infectious Disease; Infectious diseases; Integrases; Integrases - genetics; Integrons; Integrons - genetics; Life Sciences; Medical sciences; Microbiology and Parasitology; mutation; Pharmacology. Drug treatments; phylogeny; Prevalence; promoter regions; Promoter Regions, Genetic; Promoter Regions, Genetic - genetics; Promoters; provenance; Spain; Spain - epidemiology; France; Spain; Integrons; Escherichia coli; Promoters; Antibiotic resistance; Description; Genetic variability; Diversity; Genotype; Strain; Promoter; Resistance; Variant; Antibiotic; Cassette; Gene; Integron; Bacteria; Genetics; Antibacterial agent; Enterobacteriaceae

Gene cassettes of class 1 integrons may be differently expressed depending on the Pc promoter variant as well as occasionally from a second promoter located downstream of Pc, named P2. So far, the distribution of the variants has only been described in an in silico study. In this study, the prevalen...