Diversity of class 1 integron gene cassette Pc promoter variants in clinical Escherichia coli strains and description of a new P2 promoter variant
Gene cassettes of class 1 integrons may be differently expressed depending on the Pc promoter variant as well as occasionally from a second promoter located downstream of Pc, named P2. So far, the distribution of the variants has only been described in an in silico study. In this study, the prevalen...
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| Published in | International journal of antimicrobial agents Vol. 38; no. 6; pp. 526 - 529 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Amsterdam
Elsevier B.V
01.12.2011
Elsevier |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0924-8579 1872-7913 1872-7913 |
| DOI | 10.1016/j.ijantimicag.2011.07.007 |
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| Abstract | Gene cassettes of class 1 integrons may be differently expressed depending on the Pc promoter variant as well as occasionally from a second promoter located downstream of Pc, named P2. So far, the distribution of the variants has only been described in an in silico study. In this study, the prevalence of these variants in vivo was analysed in a population of 85
Escherichia coli strains from a variety of phylogenetic groups isolated from healthy subjects and clinical samples in Spain and France from 2004 to 2007. The weakest variants (PcW and PcH1) prevailed (variants associated with the integrase having the most efficient excision activity), whilst the two strongest variants, PcW
TGN-10 and PcS, were less frequent. Furthermore, a new variant of P2 associated with PcW was characterised in one integron (harbouring the gene cassette
bla
OXA-1–
aadA1) from a French strain of a healthy subject. This variant was hereafter named P2m3 and shows a G
→
A substitution in its −10 element (TACA
GT to TACA
AT), a mutation that doubled the strength of P2 and approached the level of expression of the strong PcW
TGN-10 variant. When the correlation between the Pc variants and the origin of the strains was analysed, no significant difference (
P
<
0.05) was observed in the Pc variant distribution according to the geographic origin or clinical setting. |
|---|---|
| AbstractList | Gene cassettes of class 1 integrons may be differently expressed depending on the Pc promoter variant as well as occasionally from a second promoter located downstream of Pc, named P2. So far, the distribution of the variants has only been described in an in silico study. In this study, the prevalence of these variants in vivo was analysed in a population of 85 Escherichia coli strains from a variety of phylogenetic groups isolated from healthy subjects and clinical samples in Spain and France from 2004 to 2007. The weakest variants (PcW and PcH1) prevailed (variants associated with the integrase having the most efficient excision activity), whilst the two strongest variants, PcW(TGN-10) and PcS, were less frequent. Furthermore, a new variant of P2 associated with PcW was characterised in one integron (harbouring the gene cassette bla(OXA-1)-aadA1) from a French strain of a healthy subject. This variant was hereafter named P2m3 and shows a G→A substitution in its -10 element (TACAGT to TACAAT), a mutation that doubled the strength of P2 and approached the level of expression of the strong PcW(TGN-10) variant. When the correlation between the Pc variants and the origin of the strains was analysed, no significant difference (P<0.05) was observed in the Pc variant distribution according to the geographic origin or clinical setting.Gene cassettes of class 1 integrons may be differently expressed depending on the Pc promoter variant as well as occasionally from a second promoter located downstream of Pc, named P2. So far, the distribution of the variants has only been described in an in silico study. In this study, the prevalence of these variants in vivo was analysed in a population of 85 Escherichia coli strains from a variety of phylogenetic groups isolated from healthy subjects and clinical samples in Spain and France from 2004 to 2007. The weakest variants (PcW and PcH1) prevailed (variants associated with the integrase having the most efficient excision activity), whilst the two strongest variants, PcW(TGN-10) and PcS, were less frequent. Furthermore, a new variant of P2 associated with PcW was characterised in one integron (harbouring the gene cassette bla(OXA-1)-aadA1) from a French strain of a healthy subject. This variant was hereafter named P2m3 and shows a G→A substitution in its -10 element (TACAGT to TACAAT), a mutation that doubled the strength of P2 and approached the level of expression of the strong PcW(TGN-10) variant. When the correlation between the Pc variants and the origin of the strains was analysed, no significant difference (P<0.05) was observed in the Pc variant distribution according to the geographic origin or clinical setting. Gene cassettes of class 1 integrons may be differently expressed depending on the Pc promoter variant as well as occasionally from a second promoter located downstream of Pc, named P2. So far, the distribution of the variants has only been described in an in silico study. In this study, the prevalence of these variants in vivo was analysed in a population of 85 Escherichia coli strains from a variety of phylogenetic groups isolated from healthy subjects and clinical samples in Spain and France from 2004 to 2007. The weakest variants (PcW and PcH1) prevailed (variants associated with the integrase having the most efficient excision activity), whilst the two strongest variants, PcW TGN-10 and PcS, were less frequent. Furthermore, a new variant of P2 associated with PcW was characterised in one integron (harbouring the gene cassette bla OXA-1– aadA1) from a French strain of a healthy subject. This variant was hereafter named P2m3 and shows a G → A substitution in its −10 element (TACA GT to TACA AT), a mutation that doubled the strength of P2 and approached the level of expression of the strong PcW TGN-10 variant. When the correlation between the Pc variants and the origin of the strains was analysed, no significant difference ( P < 0.05) was observed in the Pc variant distribution according to the geographic origin or clinical setting. Abstract Gene cassettes of class 1 integrons may be differently expressed depending on the Pc promoter variant as well as occasionally from a second promoter located downstream of Pc, named P2. So far, the distribution of the variants has only been described in an in silico study. In this study, the prevalence of these variants in vivo was analysed in a population of 85 Escherichia coli strains from a variety of phylogenetic groups isolated from healthy subjects and clinical samples in Spain and France from 2004 to 2007. The weakest variants (PcW and PcH1) prevailed (variants associated with the integrase having the most efficient excision activity), whilst the two strongest variants, PcWTGN-10 and PcS, were less frequent. Furthermore, a new variant of P2 associated with PcW was characterised in one integron (harbouring the gene cassette blaOXA-1 – aadA1 ) from a French strain of a healthy subject. This variant was hereafter named P2m3 and shows a G → A substitution in its −10 element (TACA G T to TACA A T), a mutation that doubled the strength of P2 and approached the level of expression of the strong PcWTGN-10 variant. When the correlation between the Pc variants and the origin of the strains was analysed, no significant difference ( P < 0.05) was observed in the Pc variant distribution according to the geographic origin or clinical setting. Gene cassettes of class 1 integrons may be differently expressed depending on the Pc promoter variant as well as occasionally from a second promoter located downstream of Pc, named P2. So far, the distribution of the variants has only been described in an in silico study. In this study, the prevalence of these variants in vivo was analysed in a population of 85 Escherichia coli strains from a variety of phylogenetic groups isolated from healthy subjects and clinical samples in Spain and France from 2004 to 2007. The weakest variants (PcW and PcH1) prevailed (variants associated with the integrase having the most efficient excision activity), whilst the two strongest variants, PcW(TGN-10) and PcS, were less frequent. Furthermore, a new variant of P2 associated with PcW was characterised in one integron (harbouring the gene cassette bla(OXA-1)-aadA1) from a French strain of a healthy subject. This variant was hereafter named P2m3 and shows a G→A substitution in its -10 element (TACAGT to TACAAT), a mutation that doubled the strength of P2 and approached the level of expression of the strong PcW(TGN-10) variant. When the correlation between the Pc variants and the origin of the strains was analysed, no significant difference (P<0.05) was observed in the Pc variant distribution according to the geographic origin or clinical setting. Gene cassettes of class 1 integrons may be differently expressed depending on the Pc promoter variant as well as occasionally from a second promoter located downstream of Pc, named P2. So far, the distribution of the variants has only been described in an in silico study. In this study, the prevalence of these variants in vivo was analysed in a population of 85 Escherichia coli strains from a variety of phylogenetic groups isolated from healthy subjects and clinical samples in Spain and France from 2004 to 2007. The weakest variants (PcW and PcH1) prevailed (variants associated with the integrase having the most efficient excision activity), whilst the two strongest variants, PcWTGN₋₁₀ and PcS, were less frequent. Furthermore, a new variant of P2 associated with PcW was characterised in one integron (harbouring the gene cassette blaOXA₋₁–aadA1) from a French strain of a healthy subject. This variant was hereafter named P2m3 and shows a G→A substitution in its −10 element (TACAGT to TACAAT), a mutation that doubled the strength of P2 and approached the level of expression of the strong PcWTGN₋₁₀ variant. When the correlation between the Pc variants and the origin of the strains was analysed, no significant difference (P<0.05) was observed in the Pc variant distribution according to the geographic origin or clinical setting. |
| Author | Vinué, Laura Torres, Carmen Ploy, Marie-Cécile Jové, Thomas |
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| Copyright | 2011 Elsevier B.V. and the International Society of Chemotherapy Elsevier B.V. and the International Society of Chemotherapy 2015 INIST-CNRS Copyright © 2011 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved. Distributed under a Creative Commons Attribution 4.0 International License |
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| Keywords | Integrons Escherichia coli Promoters Antibiotic resistance Description Genetic variability Diversity Genotype Strain Promoter Resistance Variant Antibiotic Cassette Gene Integron Bacteria Genetics Antibacterial agent Enterobacteriaceae |
| Language | English |
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| Snippet | Gene cassettes of class 1 integrons may be differently expressed depending on the Pc promoter variant as well as occasionally from a second promoter located... Abstract Gene cassettes of class 1 integrons may be differently expressed depending on the Pc promoter variant as well as occasionally from a second promoter... |
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| SubjectTerms | Antibiotic resistance Antibiotics. Antiinfectious agents. Antiparasitic agents Bacteriology Biological and medical sciences Escherichia coli Escherichia coli - genetics Escherichia coli - isolation & purification Escherichia coli Infections Escherichia coli Infections - epidemiology Escherichia coli Infections - microbiology Escherichia coli Proteins Escherichia coli Proteins - genetics France France - epidemiology genes Genetic Variation Human health and pathology Humans Infectious Disease Infectious diseases Integrases Integrases - genetics Integrons Integrons - genetics Life Sciences Medical sciences Microbiology and Parasitology mutation Pharmacology. Drug treatments phylogeny Prevalence promoter regions Promoter Regions, Genetic Promoter Regions, Genetic - genetics Promoters provenance Spain Spain - epidemiology |
| Title | Diversity of class 1 integron gene cassette Pc promoter variants in clinical Escherichia coli strains and description of a new P2 promoter variant |
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