Diffusivity and quantitative T1 profile of human visual white matter tracts after retinal ganglion cell damage

• Published in: NeuroImage clinical Vol. 23; p. 101826
• Main Authors: Takemura, Hiromasa, Ogawa, Shumpei, Mezer, Aviv A., Horiguchi, Hiroshi, Miyazaki, Atsushi, Matsumoto, Kenji, Shikishima, Keigo, Nakano, Tadashi, Masuda, Yoichiro
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.01.2019; Elsevier
• Subjects: Adult; Diffusion Magnetic Resonance Imaging - methods; Diffusion Tensor Imaging - methods; Humans; Leber's hereditary optic neuropathy; Male; MRI; Myelin; Optic Atrophy, Hereditary, Leber - diagnostic imaging; Optic Atrophy, Hereditary, Leber - metabolism; Optic radiation; Optic tract; Radiology; Regular; Retinal Ganglion Cells - metabolism; Retinal Ganglion Cells - pathology; Visual Pathways - diagnostic imaging; Visual Pathways - metabolism; White matter; White Matter - diagnostic imaging; White Matter - metabolism; Young Adult; Leber's hereditary optic neuropathy; Optic radiation; Myelin; MRI; White matter; Optic tract
• ISSN: 2213-1582; 2213-1582
• DOI: 10.1016/j.nicl.2019.101826

In patients with retinal ganglion cell diseases, recent diffusion tensor imaging (DTI) studies have revealed structural abnormalities in visual white matter tracts such as the optic tract, and optic radiation. However, the microstructural origin of these diffusivity changes is unknown as DTI metrics...