Alpha-Synuclein Pathology in Sensory Nerve Terminals of the Upper Aerodigestive Tract of Parkinson’s Disease Patients

• Published in: Dysphagia Vol. 30; no. 4; pp. 404 - 417
• Main Authors: Mu, Liancai, Chen, Jingming, Sobotka, Stanislaw, Nyirenda, Themba, Benson, Brian, Gupta, Fiona, Sanders, Ira, Adler, Charles H., Caviness, John N., Shill, Holly A., Sabbagh, Marwan, Samanta, Johan E., Sue, Lucia I., Beach, Thomas G.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.08.2015; Springer; Springer Nature B.V
• Subjects: Aged; Aged, 80 and over; alpha-Synuclein - analysis; alpha-Synuclein - biosynthesis; Arizona; Brain - metabolism; Brain Chemistry; Deglutition Disorders - etiology; Deglutition Disorders - metabolism; Female; Gastroenterology; Health aspects; Hepatology; Humans; Imaging; Male; Medical research; Medicine; Medicine & Public Health; Medicine, Experimental; Mortality; Mucous Membrane - chemistry; Original Article; Otorhinolaryngology; Parkinson Disease - complications; Parkinson Disease - metabolism; Parkinson Disease - pathology; Radiology; Arizona; Alpha-synuclein histopathology; Lewy-type synucleinopathy; Dysphagia; Upper aerodigestive tract; Peripheral sensory nerves; Parkinson’s disease

Dysphagia is common in Parkinson’s disease (PD) and causes significant morbidity and mortality. PD dysphagia has usually been explained as dysfunction of central motor control, much like other motor symptoms that are characteristic of the disease. However, PD dysphagia does not correlate with severi...