Heart filling exceeds emptying during late ventricular systole in patients with systolic heart failure and healthy subjects – a cardiac MRI study
Summary Background Total heart volume (THV) within the pericardium is not constant throughout the cardiac cycle and THV would intuitively be lowest at end systole. We have, however, observed a phase shift between ventricular outflow and atrial inflow which causes the minimum THV to occur before end...
Saved in:
| Published in | Clinical physiology and functional imaging Vol. 39; no. 3; pp. 192 - 200 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Wiley Subscription Services, Inc
01.05.2019
John Wiley and Sons Inc |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1475-0961 1475-097X 1475-097X |
| DOI | 10.1111/cpf.12555 |
Cover
Loading…
| Abstract | Summary
Background
Total heart volume (THV) within the pericardium is not constant throughout the cardiac cycle and THV would intuitively be lowest at end systole. We have, however, observed a phase shift between ventricular outflow and atrial inflow which causes the minimum THV to occur before end systole. The aims were to explain the mechanism of the late‐systolic net inflow to the heart and determine whether this net inflow is affected by increased cardiac output or systolic heart failure.
Methods and Results
Healthy controls (n = 21) and patients with EF<35% (n = 14) underwent magnetic resonance imaging with flow measurements in vessels to and from the heart, and this was repeated in nine controls during 140 μgram kg−1 min−1 adenosine infusion. Minimum THV occurred 78 ± 6 ms before end of systolic ejection (8 ± 1% of the cardiac cycle) in controls. The late‐systolic net inflow was 12·3 ± 1·1 ml or 6·0 ± 0·5% of total stroke volume (TSV). Cardiac output increased 66 ± 8% during adenosine but late‐systolic net inflow to the heart did not change (P = 0·73). In patients with heart failure, late‐systolic net inflow of the heart′s left side was lower (3·4 ± 0·5%) compared to healthy subjects (5·3 ± 0·6%, P = 0·03).
Conclusions
Heart size increases before end systole due to a late‐systolic net inflow which is unaffected by increased cardiac output. This may be explained by inertia of blood that flows into the atria generated by ventricular systole. The lower late‐systolic net inflow in patients with systolic heart failure may be a measure of decreased ventricular filling due to decreased systolic function, thus linking systolic to diastolic dysfunction. |
|---|---|
| AbstractList | Total heart volume (THV) within the pericardium is not constant throughout the cardiac cycle and THV would intuitively be lowest at end systole. We have, however, observed a phase shift between ventricular outflow and atrial inflow which causes the minimum THV to occur before end systole. The aims were to explain the mechanism of the late-systolic net inflow to the heart and determine whether this net inflow is affected by increased cardiac output or systolic heart failure.
Healthy controls (n = 21) and patients with EF<35% (n = 14) underwent magnetic resonance imaging with flow measurements in vessels to and from the heart, and this was repeated in nine controls during 140 μgram kg
min
adenosine infusion. Minimum THV occurred 78 ± 6 ms before end of systolic ejection (8 ± 1% of the cardiac cycle) in controls. The late-systolic net inflow was 12·3 ± 1·1 ml or 6·0 ± 0·5% of total stroke volume (TSV). Cardiac output increased 66 ± 8% during adenosine but late-systolic net inflow to the heart did not change (P = 0·73). In patients with heart failure, late-systolic net inflow of the heart's left side was lower (3·4 ± 0·5%) compared to healthy subjects (5·3 ± 0·6%, P = 0·03).
Heart size increases before end systole due to a late-systolic net inflow which is unaffected by increased cardiac output. This may be explained by inertia of blood that flows into the atria generated by ventricular systole. The lower late-systolic net inflow in patients with systolic heart failure may be a measure of decreased ventricular filling due to decreased systolic function, thus linking systolic to diastolic dysfunction. Total heart volume (THV) within the pericardium is not constant throughout the cardiac cycle and THV would intuitively be lowest at end systole. We have, however, observed a phase shift between ventricular outflow and atrial inflow which causes the minimum THV to occur before end systole. The aims were to explain the mechanism of the late-systolic net inflow to the heart and determine whether this net inflow is affected by increased cardiac output or systolic heart failure.BACKGROUNDTotal heart volume (THV) within the pericardium is not constant throughout the cardiac cycle and THV would intuitively be lowest at end systole. We have, however, observed a phase shift between ventricular outflow and atrial inflow which causes the minimum THV to occur before end systole. The aims were to explain the mechanism of the late-systolic net inflow to the heart and determine whether this net inflow is affected by increased cardiac output or systolic heart failure.Healthy controls (n = 21) and patients with EF<35% (n = 14) underwent magnetic resonance imaging with flow measurements in vessels to and from the heart, and this was repeated in nine controls during 140 μgram kg-1 min-1 adenosine infusion. Minimum THV occurred 78 ± 6 ms before end of systolic ejection (8 ± 1% of the cardiac cycle) in controls. The late-systolic net inflow was 12·3 ± 1·1 ml or 6·0 ± 0·5% of total stroke volume (TSV). Cardiac output increased 66 ± 8% during adenosine but late-systolic net inflow to the heart did not change (P = 0·73). In patients with heart failure, late-systolic net inflow of the heart's left side was lower (3·4 ± 0·5%) compared to healthy subjects (5·3 ± 0·6%, P = 0·03).METHODS AND RESULTSHealthy controls (n = 21) and patients with EF<35% (n = 14) underwent magnetic resonance imaging with flow measurements in vessels to and from the heart, and this was repeated in nine controls during 140 μgram kg-1 min-1 adenosine infusion. Minimum THV occurred 78 ± 6 ms before end of systolic ejection (8 ± 1% of the cardiac cycle) in controls. The late-systolic net inflow was 12·3 ± 1·1 ml or 6·0 ± 0·5% of total stroke volume (TSV). Cardiac output increased 66 ± 8% during adenosine but late-systolic net inflow to the heart did not change (P = 0·73). In patients with heart failure, late-systolic net inflow of the heart's left side was lower (3·4 ± 0·5%) compared to healthy subjects (5·3 ± 0·6%, P = 0·03).Heart size increases before end systole due to a late-systolic net inflow which is unaffected by increased cardiac output. This may be explained by inertia of blood that flows into the atria generated by ventricular systole. The lower late-systolic net inflow in patients with systolic heart failure may be a measure of decreased ventricular filling due to decreased systolic function, thus linking systolic to diastolic dysfunction.CONCLUSIONSHeart size increases before end systole due to a late-systolic net inflow which is unaffected by increased cardiac output. This may be explained by inertia of blood that flows into the atria generated by ventricular systole. The lower late-systolic net inflow in patients with systolic heart failure may be a measure of decreased ventricular filling due to decreased systolic function, thus linking systolic to diastolic dysfunction. Background: Total heart volume (THV) within the pericardium is not constant throughout the cardiac cycle and THV would intuitively be lowest at end systole. We have, however, observed a phase shift between ventricular outflow and atrial inflow which causes the minimum THV to occur before end systole. The aims were to explain the mechanism of the late-systolic net inflow to the heart and determine whether this net inflow is affected by increased cardiac output or systolic heart failure. Methods and Results: Healthy controls (n = 21) and patients with EF<35% (n = 14) underwent magnetic resonance imaging with flow measurements in vessels to and from the heart, and this was repeated in nine controls during 140 μgram kg−1 min−1 adenosine infusion. Minimum THV occurred 78 ± 6 ms before end of systolic ejection (8 ± 1% of the cardiac cycle) in controls. The late-systolic net inflow was 12·3 ± 1·1 ml or 6·0 ± 0·5% of total stroke volume (TSV). Cardiac output increased 66 ± 8% during adenosine but late-systolic net inflow to the heart did not change (P = 0·73). In patients with heart failure, late-systolic net inflow of the heart′s left side was lower (3·4 ± 0·5%) compared to healthy subjects (5·3 ± 0·6%, P = 0·03). Conclusions: Heart size increases before end systole due to a late-systolic net inflow which is unaffected by increased cardiac output. This may be explained by inertia of blood that flows into the atria generated by ventricular systole. The lower late-systolic net inflow in patients with systolic heart failure may be a measure of decreased ventricular filling due to decreased systolic function, thus linking systolic to diastolic dysfunction. Background: Total heart volume (THV) within the pericardium is not constant throughout the cardiac cycle and THV would intuitively be lowest at end systole. We have, however, observed a phase shift between ventricular outflow and atrial inflow which causes the minimum THV to occur before end systole. The aims were to explain the mechanism of the late-systolic net inflow to the heart and determine whether this net inflow is affected by increased cardiac output or systolic heart failure. Methods and Results: Healthy controls (n = 21) and patients with EF<35% (n = 14) underwent magnetic resonance imaging with flow measurements in vessels to and from the heart, and this was repeated in nine controls during 140 μgram kg−1 min−1 adenosine infusion. Minimum THV occurred 78 ± 6 ms before end of systolic ejection (8 ± 1% of the cardiac cycle) in controls. The late-systolic net inflow was 12·3 ± 1·1 ml or 6·0 ± 0·5% of total stroke volume (TSV). Cardiac output increased 66 ± 8% during adenosine but late-systolic net inflow to the heart did not change (P = 0·73). In patients with heart failure, late-systolic net inflow of the heart′s left side was lower (3·4 ± 0·5%) compared to healthy subjects (5·3 ± 0·6%, P = 0·03). Conclusions: Heart size increases before end systole due to a late-systolic net inflow which is unaffected by increased cardiac output. This may be explained by inertia of blood that flows into the atria generated by ventricular systole. The lower late-systolic net inflow in patients with systolic heart failure may be a measure of decreased ventricular filling due to decreased systolic function, thus linking systolic to diastolic dysfunction. BackgroundTotal heart volume (THV) within the pericardium is not constant throughout the cardiac cycle and THV would intuitively be lowest at end systole. We have, however, observed a phase shift between ventricular outflow and atrial inflow which causes the minimum THV to occur before end systole. The aims were to explain the mechanism of the late‐systolic net inflow to the heart and determine whether this net inflow is affected by increased cardiac output or systolic heart failure.Methods and ResultsHealthy controls (n = 21) and patients with EF<35% (n = 14) underwent magnetic resonance imaging with flow measurements in vessels to and from the heart, and this was repeated in nine controls during 140 μgram kg−1 min−1 adenosine infusion. Minimum THV occurred 78 ± 6 ms before end of systolic ejection (8 ± 1% of the cardiac cycle) in controls. The late‐systolic net inflow was 12·3 ± 1·1 ml or 6·0 ± 0·5% of total stroke volume (TSV). Cardiac output increased 66 ± 8% during adenosine but late‐systolic net inflow to the heart did not change (P = 0·73). In patients with heart failure, late‐systolic net inflow of the heart′s left side was lower (3·4 ± 0·5%) compared to healthy subjects (5·3 ± 0·6%, P = 0·03).ConclusionsHeart size increases before end systole due to a late‐systolic net inflow which is unaffected by increased cardiac output. This may be explained by inertia of blood that flows into the atria generated by ventricular systole. The lower late‐systolic net inflow in patients with systolic heart failure may be a measure of decreased ventricular filling due to decreased systolic function, thus linking systolic to diastolic dysfunction. Summary Background Total heart volume (THV) within the pericardium is not constant throughout the cardiac cycle and THV would intuitively be lowest at end systole. We have, however, observed a phase shift between ventricular outflow and atrial inflow which causes the minimum THV to occur before end systole. The aims were to explain the mechanism of the late‐systolic net inflow to the heart and determine whether this net inflow is affected by increased cardiac output or systolic heart failure. Methods and Results Healthy controls (n = 21) and patients with EF<35% (n = 14) underwent magnetic resonance imaging with flow measurements in vessels to and from the heart, and this was repeated in nine controls during 140 μgram kg−1 min−1 adenosine infusion. Minimum THV occurred 78 ± 6 ms before end of systolic ejection (8 ± 1% of the cardiac cycle) in controls. The late‐systolic net inflow was 12·3 ± 1·1 ml or 6·0 ± 0·5% of total stroke volume (TSV). Cardiac output increased 66 ± 8% during adenosine but late‐systolic net inflow to the heart did not change (P = 0·73). In patients with heart failure, late‐systolic net inflow of the heart′s left side was lower (3·4 ± 0·5%) compared to healthy subjects (5·3 ± 0·6%, P = 0·03). Conclusions Heart size increases before end systole due to a late‐systolic net inflow which is unaffected by increased cardiac output. This may be explained by inertia of blood that flows into the atria generated by ventricular systole. The lower late‐systolic net inflow in patients with systolic heart failure may be a measure of decreased ventricular filling due to decreased systolic function, thus linking systolic to diastolic dysfunction. |
| Author | Kanski, Mikael Borgquist, Rasmus Ekelund, Ulf Arheden, Håkan Carlsson, Marcus Ugander, Martin |
| AuthorAffiliation | 1 Department of Clinical Sciences, Clinical Physiology Skane University Hospital Lund University Lund Sweden 3 Department of Clinical Sciences, Emergency Medicine Skane University Hospital Lund University Lund Sweden 2 Department of Clinical Sciences, Cardiology Skane University Hospital Lund University Lund Sweden |
| AuthorAffiliation_xml | – name: 1 Department of Clinical Sciences, Clinical Physiology Skane University Hospital Lund University Lund Sweden – name: 3 Department of Clinical Sciences, Emergency Medicine Skane University Hospital Lund University Lund Sweden – name: 2 Department of Clinical Sciences, Cardiology Skane University Hospital Lund University Lund Sweden |
| Author_xml | – sequence: 1 givenname: Marcus orcidid: 0000-0002-9480-5250 surname: Carlsson fullname: Carlsson, Marcus email: marcus.carlsson@med.lu.se organization: Lund University – sequence: 2 givenname: Martin surname: Ugander fullname: Ugander, Martin organization: Lund University – sequence: 3 givenname: Mikael surname: Kanski fullname: Kanski, Mikael organization: Lund University – sequence: 4 givenname: Rasmus surname: Borgquist fullname: Borgquist, Rasmus organization: Lund University – sequence: 5 givenname: Ulf surname: Ekelund fullname: Ekelund, Ulf organization: Lund University – sequence: 6 givenname: Håkan surname: Arheden fullname: Arheden, Håkan organization: Lund University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30506862$$D View this record in MEDLINE/PubMed https://lup.lub.lu.se/record/7b37519c-21d1-46e9-8d72-76117af27cc9$$DView record from Swedish Publication Index oai:portal.research.lu.se:publications/7b37519c-21d1-46e9-8d72-76117af27cc9$$DView record from Swedish Publication Index http://kipublications.ki.se/Default.aspx?queryparsed=id:140627465$$DView record from Swedish Publication Index |
| BookMark | eNqNks1u1DAQxyNURD_gwAsgS1zgsK2dOHFyQUIrSistAiGQuFmOPel68Sap7XTZG-_QN-RJmHSXFa20iEiRrZnf_OfDc5wctF0LSfKc0VOG35num1OW5nn-KDliXOQTWolvB7t7wQ6T4xAWlDKRcfEkOcxoTouySI-S2wtQPpLGOmfbKwI_NIAJBJZ9XI8GM_jxcCoCuYE2eqsHpzwJ6xA7B8S2pFfRoieQlY3zrcNqMt8IK-sGD0S1ZrS4OF-TMNQL0Bjw6-ctUUQrb6zS5MPnSxLiYNZPk8eNcgGebc-T5Ov5uy_Ti8ns4_vL6dvZRBec5pOaspSzrMyEUTRtoOImq4qG5mg2lamqukw51IyzuhQVGChKo4HRpoECDOfZSTLZ6IYV9EMte2-Xyq9lp6zcmr7jDSQvs0KUyKu9fN_5qJz0ELBtPZduGAORwlHgfLo2SFFnImeVlikzTPICKlkakUpRMCZUkwqtK8wx25vDDT3-9Vb7P-XebORQawnYPr4glnmv8nue1s7lVXcjRVZSSgsUeLUV8N31ACHKpQ0anFMtdEPA5LyiqaD5iL58gC66wbf4gjJNKcspoyVF6sXfFe1K-bOSCLzeANp3IXhodgijclx3iesu79Yd2bMHrLbxbtzYjHX_ilhZB-v90nL66XwT8RuEzRV6 |
| CitedBy_id | crossref_primary_10_1152_japplphysiol_00257_2022 |
| Cites_doi | 10.1152/ajpheart.00058.2015 10.1016/j.jacc.2017.09.1156 10.1111/j.1475-097X.2005.00617.x 10.1016/S0735-1097(99)00300-9 10.1186/1471-2342-10-1 10.1081/JCMR-120016389 10.1152/japplphysiol.00932.2012 10.1152/ajpheart.00566.2004 10.1152/ajpheart.01148.2006 10.1023/B:CAIM.0000014049.29239.25 10.1152/ajpheart.00544.2015 10.1016/S0002-9149(98)00452-4 10.1111/cpf.12020 10.1152/ajpheart.00249.2003 10.1152/japplphysiol.00799.2007 10.1152/ajpheart.00942.2011 10.1152/ajpheart.01125.2003 10.1186/s12968-015-0211-4 10.1111/cpf.12125 10.1186/1532-429X-15-96 10.1152/ajpheart.00744.2004 10.1113/jphysiol.1994.sp020454 10.1136/heart.87.2.121 10.1152/ajpheart.00969.2003 10.1152/ajpheart.01376.2006 10.1152/ajpheart.1998.275.3.H1062 10.1016/S0002-9149(02)02794-7 10.1042/CS20010196 10.1038/35008075 10.1161/01.RES.23.5.663 10.1111/j.1475-097X.2012.01150.x 10.1016/j.jacc.2017.06.046 10.1148/radiol.2302021309 10.1152/ajpheart.00483.2015 10.1081/JCMR-120016383 |
| ContentType | Journal Article |
| Copyright | 2018 The Authors. published by John Wiley & Sons Ltd on behalf of Scandinavian Society of Clinical Physiology and Nuclear Medicine 2018 The Authors. Clinical Physiology and Functional Imaging published by John Wiley & Sons Ltd on behalf of Scandinavian Society of Clinical Physiology and Nuclear Medicine. Copyright © 2019 Scandinavian Society of Clinical Physiology and Nuclear Medicine |
| Copyright_xml | – notice: 2018 The Authors. published by John Wiley & Sons Ltd on behalf of Scandinavian Society of Clinical Physiology and Nuclear Medicine – notice: 2018 The Authors. Clinical Physiology and Functional Imaging published by John Wiley & Sons Ltd on behalf of Scandinavian Society of Clinical Physiology and Nuclear Medicine. – notice: Copyright © 2019 Scandinavian Society of Clinical Physiology and Nuclear Medicine |
| CorporateAuthor | Medicin/akutsjukvård, Lund Section V Institutionen för kliniska vetenskaper, Lund Sektion II Lunds universitet Hjärt-MR-gruppen i Lund Section II Lund University Sektion V Experimental Vascular Research Kardiologi Experimentell kärlforskning Department of Clinical Sciences, Lund Medicine/Emergency Medicine, Lund Lund Cardiac MR Group Faculty of Medicine Klinisk fysiologi, Lund Clinical Physiology (Lund) Medicinska fakulteten Cardiology |
| CorporateAuthor_xml | – name: Faculty of Medicine – name: Medicinska fakulteten – name: Klinisk fysiologi, Lund – name: Hjärt-MR-gruppen i Lund – name: Clinical Physiology (Lund) – name: Sektion II – name: Kardiologi – name: Medicine/Emergency Medicine, Lund – name: Section II – name: Lund Cardiac MR Group – name: Institutionen för kliniska vetenskaper, Lund – name: Cardiology – name: Lunds universitet – name: Experimental Vascular Research – name: Department of Clinical Sciences, Lund – name: Lund University – name: Sektion V – name: Section V – name: Experimentell kärlforskning – name: Medicin/akutsjukvård, Lund |
| DBID | 24P AAYXX CITATION NPM 7QP 7TS 7U5 8FD K9. L7M 7X8 5PM ADTPV AGCHP AOWAS D8T D95 ZZAVC |
| DOI | 10.1111/cpf.12555 |
| DatabaseName | Wiley Online Library Open Access CrossRef PubMed Calcium & Calcified Tissue Abstracts Physical Education Index Solid State and Superconductivity Abstracts Technology Research Database ProQuest Health & Medical Complete (Alumni) Advanced Technologies Database with Aerospace MEDLINE - Academic PubMed Central (Full Participant titles) SwePub SWEPUB Lunds universitet full text SwePub Articles SWEPUB Freely available online SWEPUB Lunds universitet SwePub Articles full text |
| DatabaseTitle | CrossRef PubMed ProQuest Health & Medical Complete (Alumni) Solid State and Superconductivity Abstracts Technology Research Database Calcium & Calcified Tissue Abstracts Advanced Technologies Database with Aerospace Physical Education Index MEDLINE - Academic |
| DatabaseTitleList | PubMed MEDLINE - Academic ProQuest Health & Medical Complete (Alumni) |
| Database_xml | – sequence: 1 dbid: 24P name: Open Access: Wiley-Blackwell Open Access Journals url: https://authorservices.wiley.com/open-science/open-access/browse-journals.html sourceTypes: Publisher – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| DocumentTitleAlternate | M. Carlsson et al |
| EISSN | 1475-097X |
| EndPage | 200 |
| ExternalDocumentID | oai_swepub_ki_se_483678 oai_portal_research_lu_se_publications_7b37519c_21d1_46e9_8d72_76117af27cc9 oai_lup_lub_lu_se_7b37519c_21d1_46e9_8d72_76117af27cc9 PMC7380006 30506862 10_1111_cpf_12555 CPF12555 |
| Genre | article Journal Article |
| GrantInformation_xml | – fundername: Swedish Medical Association – fundername: Swedish Heart Lung foundation – fundername: Lund University, Sweden – fundername: Region of Skåne, Sweden – fundername: Swedish Research Council funderid: 2016‐01617 – fundername: Faculty of Medicine – fundername: Swedish Research Council grantid: 2016-01617 – fundername: ; – fundername: ; grantid: 2016‐01617 |
| GroupedDBID | --- .3N .GA .GJ .Y3 05W 0R~ 10A 1OC 24P 29B 31~ 33P 36B 3SF 4.4 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5GY 5HH 5LA 5RE 5VS 66C 6J9 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 AAESR AAEVG AAHHS AAHQN AAIPD AAKAS AAMNL AANHP AANLZ AAONW AASGY AAXRX AAYCA AAZKR ABCQN ABCUV ABEML ABJNI ABPVW ABQWH ABXGK ACAHQ ACBWZ ACCFJ ACCZN ACGFO ACGFS ACGOF ACIWK ACMXC ACPOU ACPRK ACRPL ACSCC ACXBN ACXQS ACYXJ ADBBV ADBTR ADEOM ADIZJ ADKYN ADMGS ADNMO ADOZA ADXAS ADZCM ADZMN ADZOD AEEZP AEIGN AEIMD AENEX AEQDE AEUQT AEUYR AFBPY AFEBI AFFPM AFGKR AFPWT AFRAH AFWVQ AFZJQ AHBTC AHMBA AIACR AIAGR AITYG AIURR AIWBW AJBDE ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN ALVPJ AMBMR AMYDB ATUGU AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BMXJE BROTX BRXPI BY8 C45 CAG COF CS3 D-6 D-7 D-E D-F DCZOG DPXWK DR2 DRFUL DRMAN DRSTM DU5 EBS EJD EMOBN ESX EX3 F00 F01 F04 F5P FEDTE FUBAC G-S G.N GODZA H.X HF~ HGLYW HVGLF HZI HZ~ IHE IX1 J0M K48 KBYEO LATKE LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES MEWTI MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N9A NF~ O66 O9- OIG OVD P2P P2W P2X P2Z P4B P4D PQQKQ Q.N Q11 QB0 R.K RJQFR ROL RX1 SUPJJ TEORI UB1 V8K W8V W99 WBKPD WHWMO WIH WIJ WIK WOHZO WOW WQJ WRC WVDHM WXI WXSBR XG1 ~IA ~WT AAYXX AEYWJ AGHNM AGQPQ AGYGG CITATION NPM 7QP 7TS 7U5 8FD AAMMB AEFGJ AGXDD AIDQK AIDYY K9. L7M 7X8 1OB 5PM ADTPV AGCHP AOWAS D8T D95 ZZAVC |
| ID | FETCH-LOGICAL-c6405-b012413837da02fe94d396f05124d9d99b824eb141b879ede68dce10ffe6ed443 |
| IEDL.DBID | 24P |
| ISSN | 1475-0961 1475-097X |
| IngestDate | Mon Sep 01 03:32:10 EDT 2025 Thu Aug 21 06:46:17 EDT 2025 Thu Jul 03 05:19:22 EDT 2025 Thu Aug 21 18:27:33 EDT 2025 Fri Jul 11 02:14:24 EDT 2025 Sun Jul 13 04:46:03 EDT 2025 Wed Feb 19 02:32:58 EST 2025 Tue Jul 01 01:42:46 EDT 2025 Thu Apr 24 23:03:26 EDT 2025 Wed Jan 22 16:26:01 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 3 |
| Keywords | cardiac output diastolic dysfunction cardiac pumping |
| Language | English |
| License | Attribution 2018 The Authors. Clinical Physiology and Functional Imaging published by John Wiley & Sons Ltd on behalf of Scandinavian Society of Clinical Physiology and Nuclear Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c6405-b012413837da02fe94d396f05124d9d99b824eb141b879ede68dce10ffe6ed443 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| ORCID | 0000-0002-9480-5250 |
| OpenAccessLink | https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fcpf.12555 |
| PMID | 30506862 |
| PQID | 2201501080 |
| PQPubID | 1006519 |
| PageCount | 9 |
| ParticipantIDs | swepub_primary_oai_swepub_ki_se_483678 swepub_primary_oai_portal_research_lu_se_publications_7b37519c_21d1_46e9_8d72_76117af27cc9 swepub_primary_oai_lup_lub_lu_se_7b37519c_21d1_46e9_8d72_76117af27cc9 pubmedcentral_primary_oai_pubmedcentral_nih_gov_7380006 proquest_miscellaneous_2149027056 proquest_journals_2201501080 pubmed_primary_30506862 crossref_primary_10_1111_cpf_12555 crossref_citationtrail_10_1111_cpf_12555 wiley_primary_10_1111_cpf_12555_CPF12555 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | May 2019 |
| PublicationDateYYYYMMDD | 2019-05-01 |
| PublicationDate_xml | – month: 05 year: 2019 text: May 2019 |
| PublicationDecade | 2010 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England – name: Oxford – name: Hoboken |
| PublicationTitle | Clinical physiology and functional imaging |
| PublicationTitleAlternate | Clin Physiol Funct Imaging |
| PublicationYear | 2019 |
| Publisher | Wiley Subscription Services, Inc John Wiley and Sons Inc |
| Publisher_xml | – name: Wiley Subscription Services, Inc – name: John Wiley and Sons Inc |
| References | 2015; 35 2004; 287 2004; 286 2010; 10 1968; 23 2004; 20 2015; 17 2013b; 15 2013a; 33 2015; 309 2015; 308 2002; 4 2008; 105 1998; 82 2012; 302 1998; 275 2007a; 293 2012; 32 2005; 25 2011; 2011 2004; 230 1986; 127 2017; 70 2005; 288 2007b; 292 2002; 102 2000; 404 2002; 87 1994; 481 1999; 34 2016; 310 2013; 114 2002; 90 2018; 71 2003; 285 e_1_2_8_28_1 e_1_2_8_29_1 e_1_2_8_24_1 e_1_2_8_25_1 e_1_2_8_26_1 e_1_2_8_27_1 e_1_2_8_3_1 e_1_2_8_2_1 e_1_2_8_5_1 Lundback S (e_1_2_8_19_1) 1986; 127 e_1_2_8_4_1 e_1_2_8_7_1 e_1_2_8_6_1 e_1_2_8_9_1 e_1_2_8_8_1 e_1_2_8_20_1 e_1_2_8_21_1 e_1_2_8_22_1 e_1_2_8_23_1 Giovangrandi L (e_1_2_8_15_1) 2011; 2011 e_1_2_8_17_1 e_1_2_8_18_1 e_1_2_8_13_1 e_1_2_8_36_1 e_1_2_8_14_1 e_1_2_8_35_1 e_1_2_8_38_1 e_1_2_8_16_1 e_1_2_8_37_1 e_1_2_8_32_1 e_1_2_8_10_1 e_1_2_8_31_1 e_1_2_8_11_1 e_1_2_8_34_1 e_1_2_8_12_1 e_1_2_8_33_1 e_1_2_8_30_1 |
| References_xml | – volume: 15 start-page: 96 year: 2013b article-title: Moderate intensity supine exercise causes decreased cardiac volumes and increased outer volume variations: a cardiovascular magnetic resonance study publication-title: J Cardiovasc Magn Reson – volume: 10 start-page: 1 year: 2010 article-title: Design and validation of Segment–freely available software for cardiovascular image analysis publication-title: BMC Med Imaging – volume: 2011 start-page: 4279 year: 2011 end-page: 4282 article-title: Ballistocardiography–a method worth revisiting publication-title: Conf Proc IEEE Eng Med Biol Soc – volume: 32 start-page: 415 year: 2012 end-page: 420 article-title: Using ballistocardiography to measure cardiac performance: a brief review of its history and future significance publication-title: Clin Physiol Funct Imaging – volume: 90 start-page: 1174 year: 2002 end-page: 1177 article-title: Color tissue Doppler‐derived long‐axis left ventricular function in heart failure with preserved global systolic function publication-title: Am J Cardiol – volume: 287 start-page: H243 year: 2004 end-page: H250 article-title: Total heart volume variation throughout the cardiac cycle in humans publication-title: Am J Physiol Heart Circ Physiol – volume: 4 start-page: 443 year: 2002 end-page: 457 article-title: Normal systolic and diastolic functions of the left ventricle and left atrium by cine magnetic resonance imaging publication-title: J Cardiovasc Magn Reson – volume: 33 start-page: 233 year: 2013a end-page: 240 article-title: Atrial aspiration from pulmonary and caval veins is caused by ventricular contraction and secures 70% of the total stroke volume independent of resting heart rate and heart size publication-title: Clin Physiol Funct Imaging – volume: 102 start-page: 515 year: 2002 end-page: 522 article-title: Left ventricular long‐axis changes in early diastole and systole: impact of systolic function on diastole publication-title: Clin Sci (Lond) – volume: 285 start-page: H2027 year: 2003 end-page: H2033 article-title: Assessment and consequences of the constant‐volume attribute of the four‐chambered heart publication-title: Am J Physiol Heart Circ Physiol – volume: 288 start-page: H848 year: 2005 end-page: H853 article-title: MRI‐determined left ventricular “crescent effect”: a consequence of the slight deviation of contents of the pericardial sack from the constant‐volume state publication-title: Am J Physiol Heart Circ Physiol – volume: 71 start-page: 254 year: 2018 end-page: 255 article-title: Functional contribution of circumferential versus longitudinal strain: different concepts suggest conflicting results publication-title: J Am Coll Cardiol – volume: 82 start-page: 756 year: 1998 end-page: 761 article-title: Increasing degrees of left ventricular filling impairment modulate left atrial function in humans publication-title: Am J Cardiol – volume: 35 start-page: 49 year: 2015 end-page: 56 article-title: Submaximal adenosine‐induced coronary hyperaemia with 12 h caffeine abstinence: implications for clinical adenosine perfusion imaging tests publication-title: Clin Physiol Funct Imaging – volume: 127 start-page: 8 year: 1986 end-page: 101 article-title: Cardiac pumping and function of the ventricular septum publication-title: Acta Physiol Scand – volume: 481 start-page: 457 year: 1994 end-page: 468 article-title: Effect of dynamic exercise on left atrial function in conscious dogs publication-title: J Physiol – volume: 275 start-page: H1062 year: 1998 end-page: H1069 article-title: Mechanics of intraventricular filling: study of LV early diastolic pressure gradients and flow velocities publication-title: Am J Physiol‐Heart Circ Physiol – volume: 17 start-page: 111 year: 2015 article-title: Left ventricular fluid kinetic energy time curves in heart failure from cardiovascular magnetic resonance 4D flow data publication-title: J Cardiovasc Magn Reson – volume: 292 start-page: H1452 year: 2007b end-page: H1459 article-title: Atrioventricular plane displacement is the major contributor to left ventricular pumping in healthy adults, athletes, and patients with dilated cardiomyopathy publication-title: Am J Physiol Heart Circ Physiol – volume: 302 start-page: H893 year: 2012 end-page: H900 article-title: Quantification of left and right ventricular kinetic energy using four‐dimensional intracardiac magnetic resonance imaging flow measurements publication-title: Am J Physiol Heart Circ Physiol – volume: 34 start-page: 802 year: 1999 end-page: 809 article-title: The pulmonary venous systolic flow pulse–its origin and relationship to left atrial pressure publication-title: J Am Coll Cardiol – volume: 20 start-page: 101 year: 2004 end-page: 106 article-title: Correlation of the M‐mode atrioventricular plane early diastolic downward slope and systolic parameters. Coupling of LV systolic and early diastolic function publication-title: Int J Cardiovasc Imaging – volume: 87 start-page: 121 year: 2002 end-page: 125 article-title: Left ventricular long axis function in diastolic heart failure is reduced in both diastole and systole: time for a redefinition? publication-title: Heart – volume: 105 start-page: 1012 year: 2008 end-page: 1014 article-title: Is left ventricular volume during diastasis the real equilibrium volume, and what is its relationship to diastolic suction? publication-title: J Appl Physiol – volume: 310 start-page: H113 year: 2016 end-page: H122 article-title: Determinants of kinetic energy of blood flow in the four‐chambered heart in athletes and sedentary controls publication-title: Am J Physiol Heart Circ Physiol – volume: 114 start-page: 1472 year: 2013 end-page: 1481 article-title: Quantification of left and right atrial kinetic energy using four‐dimensional intracardiac magnetic resonance imaging flow measurements publication-title: J Appl Physiol – volume: 288 start-page: H2140 year: 2005 end-page: H2145 article-title: Reservoir and conduit function of right atrium: impact on right ventricular filling and cardiac output publication-title: Am J Physiol Heart Circ Physiol – volume: 309 start-page: H1094 year: 2015 end-page: H1096 article-title: Letter to the Editor: atrioventricular plane displacement is not the sole mechanism of atrial and ventricular refill publication-title: Am J Physiol Heart Circ Physiol – volume: 404 start-page: 759 year: 2000 end-page: 761 article-title: Asymmetric redirection of flow through the heart publication-title: Nature – volume: 230 start-page: 383 year: 2004 end-page: 388 article-title: Accurate quantification of right ventricular mass at MR imaging by using cine true fast imaging with steady‐state precession: study in dogs publication-title: Radiology – volume: 25 start-page: 226 year: 2005 end-page: 233 article-title: Center of volume and total heart volume variation in healthy subjects and patients before and after coronary bypass surgery publication-title: Clin Physiol Funct Imaging – volume: 293 start-page: H636 year: 2007a end-page: H644 article-title: The quantitative relationship between longitudinal and radial function in left, right, and total heart pumping in humans publication-title: Am J Physiol Heart Circ Physiol – volume: 23 start-page: 663 year: 1968 end-page: 670 article-title: The contribution of blood momentum to left ventricular ejection in the dog publication-title: Circ Res – volume: 308 start-page: H1317 year: 2015 end-page: H1320 article-title: Atrioventricular plane displacement is the sole mechanism of atrial and ventricular refill publication-title: Am J Physiol Heart Circ Physiol – volume: 286 start-page: H2416 year: 2004 end-page: H2424 article-title: Left atrial conduit volume is generated by deviation from the constant‐volume state of the left heart: a combined MRI‐echocardiographic study publication-title: Am J Physiol Heart Circ Physiol – volume: 4 start-page: 507 year: 2002 end-page: 513 article-title: Ventricular volume and mass by CMR publication-title: J Cardiovasc Magn Reson – volume: 70 start-page: 942 year: 2017 end-page: 954 article-title: Geometry as a Confounder When Assessing Ventricular Systolic Function: comparison Between Ejection Fraction and Strain publication-title: J Am Coll Cardiol – ident: e_1_2_8_2_1 doi: 10.1152/ajpheart.00058.2015 – ident: e_1_2_8_13_1 doi: 10.1016/j.jacc.2017.09.1156 – ident: e_1_2_8_8_1 doi: 10.1111/j.1475-097X.2005.00617.x – ident: e_1_2_8_27_1 doi: 10.1016/S0735-1097(99)00300-9 – ident: e_1_2_8_16_1 doi: 10.1186/1471-2342-10-1 – ident: e_1_2_8_23_1 doi: 10.1081/JCMR-120016389 – ident: e_1_2_8_3_1 doi: 10.1152/japplphysiol.00932.2012 – ident: e_1_2_8_14_1 doi: 10.1152/ajpheart.00566.2004 – ident: e_1_2_8_10_1 doi: 10.1152/ajpheart.01148.2006 – ident: e_1_2_8_35_1 doi: 10.1023/B:CAIM.0000014049.29239.25 – ident: e_1_2_8_30_1 doi: 10.1152/ajpheart.00544.2015 – ident: e_1_2_8_24_1 doi: 10.1016/S0002-9149(98)00452-4 – volume: 2011 start-page: 4279 year: 2011 ident: e_1_2_8_15_1 article-title: Ballistocardiography–a method worth revisiting publication-title: Conf Proc IEEE Eng Med Biol Soc – volume: 127 start-page: 8 year: 1986 ident: e_1_2_8_19_1 article-title: Cardiac pumping and function of the ventricular septum publication-title: Acta Physiol Scand – ident: e_1_2_8_28_1 doi: 10.1111/cpf.12020 – ident: e_1_2_8_5_1 doi: 10.1152/ajpheart.00249.2003 – ident: e_1_2_8_38_1 doi: 10.1152/japplphysiol.00799.2007 – ident: e_1_2_8_11_1 doi: 10.1152/ajpheart.00942.2011 – ident: e_1_2_8_7_1 doi: 10.1152/ajpheart.01125.2003 – ident: e_1_2_8_17_1 doi: 10.1186/s12968-015-0211-4 – ident: e_1_2_8_12_1 doi: 10.1111/cpf.12125 – ident: e_1_2_8_29_1 doi: 10.1186/1532-429X-15-96 – ident: e_1_2_8_34_1 doi: 10.1152/ajpheart.00744.2004 – ident: e_1_2_8_21_1 doi: 10.1113/jphysiol.1994.sp020454 – ident: e_1_2_8_36_1 doi: 10.1136/heart.87.2.121 – ident: e_1_2_8_6_1 doi: 10.1152/ajpheart.00969.2003 – ident: e_1_2_8_9_1 doi: 10.1152/ajpheart.01376.2006 – ident: e_1_2_8_26_1 doi: 10.1152/ajpheart.1998.275.3.H1062 – ident: e_1_2_8_20_1 doi: 10.1016/S0002-9149(02)02794-7 – ident: e_1_2_8_37_1 doi: 10.1042/CS20010196 – ident: e_1_2_8_18_1 doi: 10.1038/35008075 – ident: e_1_2_8_22_1 doi: 10.1161/01.RES.23.5.663 – ident: e_1_2_8_33_1 doi: 10.1111/j.1475-097X.2012.01150.x – ident: e_1_2_8_31_1 doi: 10.1016/j.jacc.2017.06.046 – ident: e_1_2_8_25_1 doi: 10.1148/radiol.2302021309 – ident: e_1_2_8_4_1 doi: 10.1152/ajpheart.00483.2015 – ident: e_1_2_8_32_1 doi: 10.1081/JCMR-120016383 |
| SSID | ssj0017347 |
| Score | 2.2034152 |
| Snippet | Summary
Background
Total heart volume (THV) within the pericardium is not constant throughout the cardiac cycle and THV would intuitively be lowest at end... Total heart volume (THV) within the pericardium is not constant throughout the cardiac cycle and THV would intuitively be lowest at end systole. We have,... BackgroundTotal heart volume (THV) within the pericardium is not constant throughout the cardiac cycle and THV would intuitively be lowest at end systole. We... Background: Total heart volume (THV) within the pericardium is not constant throughout the cardiac cycle and THV would intuitively be lowest at end systole. We... |
| SourceID | swepub pubmedcentral proquest pubmed crossref wiley |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 192 |
| SubjectTerms | Adenosine Atria Blood vessels Cardiac and Cardiovascular Systems Cardiac output cardiac pumping Cardiology and Cardiovascular Disease Clinical Medicine Congestive heart failure Control methods diastolic dysfunction Ejection Heart Heart failure Inflow Kardiologi Kardiologi och kardiovaskulära sjukdomar Klinisk medicin Magnetic resonance imaging Medical and Health Sciences Medicin och hälsovetenskap Mutual funds NMR Nuclear magnetic resonance Original Patients Pericardium Stroke volume Systole Ventricle |
| Title | Heart filling exceeds emptying during late ventricular systole in patients with systolic heart failure and healthy subjects – a cardiac MRI study |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fcpf.12555 https://www.ncbi.nlm.nih.gov/pubmed/30506862 https://www.proquest.com/docview/2201501080 https://www.proquest.com/docview/2149027056 https://pubmed.ncbi.nlm.nih.gov/PMC7380006 https://lup.lub.lu.se/record/7b37519c-21d1-46e9-8d72-76117af27cc9 oai:portal.research.lu.se:publications/7b37519c-21d1-46e9-8d72-76117af27cc9 http://kipublications.ki.se/Default.aspx?queryparsed=id:140627465 |
| Volume | 39 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1fi9QwEA_nCeKL-N_qKVFEfKls27Rp8EnOW1Zh5Tg8OHwJaf6w5dZuue6Cvvkd7hv6SZxJs-XKrXAPXZZNOls6mcwvk5lfCHmb6aoSzNlYaG1jPA8pBhQyibVRnBvBtGNYnDz_VsxO2dez_GyPfNzWwvT8EEPADS3Dz9do4Krqrhi5bt0H8M55fovcxtJaHOQpOx62EHjmTxdLGM9jPNck0AphGs9w69gZXUOY1xMlA53oGMl6VzS9T-4FDEk_9Up_QPZs85DcmYdd8kfkcgbDd01d7fm2qf2FLqqj9me7xqIm2pcm0iXATIrpjj4GqC4osjqvlpbWDQ10qx3FOG1oqDVd9IJVjcnsVDWG9nWUv2m3qTCi09G_fy6potoPPE3nJ1-oZ7B9TE6nR98PZ3E4fCHWBYC4uALPBQ4O1q9GTVJnBTOZKBzYcMqMMEJUZcpgomdJVXJhjS1KeE3JxDlbWMNY9oTsN6vGPiM0BxBWcJdPVKJYqVMFEEMLV1puAH_aIiLvt1qQOjCT4wEZS7ldoYDCpFdYRN4MXduejmNXp4OtKmWwyE6mKcZ2MKMyIq-HZrAl3CBRjV1toA8sF2GZDpgwIk97zQ__AvOir6aJCB-NiaED8nSPW5p64fm6eVYiKojIUT96RrcsNy1cFVyys5JXGQdMreFRTCJZYYUsDU8lL5KEK5dyrUVEfuyQ06_WZKCIWgR57ZXY7w2Fv9shPPx0XqNMVmaAcEBp3gT-rwZ5eDz1X57fvOsLchf0JPqM0gOyv77Y2JeA-tbVK2_d8Pn5JP0H9jpaEw |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1fa9swEBddB9texv7PXbdpY4y9uMS2bFmwl1Ea0q0pZbRQ9iJk_SFmqRPqBLa3fYd-w32S3cmKaWgGfTCESD6HnM730-nud4R8yHRVCeZsLLS2MfZDigGFDGJtFOdGMO0YFiePj4vRGft6np9vkc-rWpiOH6IPuKFl-Pc1GjgGpK9ZuZ67PXDPeX6H3GVFyrFxQ8pO-jMEnvn2YgnjeYyNTQKvEObx9Leue6MbEPNmpmTgE12Hst4XDR-RhwFE0i-d1h-TLds8IffG4Zj8KbkawfpdUFd7wm1qf6GPaqm9mC-wqol2tYl0CjiTYr6jDwKqS4q0zrOppXVDA99qSzFQGwZqTSedYFVjNjtVjaFdIeVv2i4rDOm09O-fK6qo9itP0_H3Q-opbJ-Rs-HB6f4oDt0XYl0AiosrcF3g4WADa9QgdVYwk4nCgRGnzAgjRFWmDN70LKlKLqyxRQl_UzJwzhbWMJY9J9vNrLEvCc0BhRXc5QOVKFbqVAHG0MKVlhsAoLaIyKeVFqQO1OTYIWMqV1sUUJj0CovI-37qvOPj2DRpd6VKGUyylWmKwR1MqYzIu34YjAlPSFRjZ0uYA_tF2KcDKIzIi07z_VPgxejLaSLC19ZEPwGJutdHmnriCbt5ViIsiMhBt3rWbpku53BVcMnWSl5lHEC1hp9iEskKK2RpeCp5kSRcuZRrLSLyY4OcbrsmA0fUJMibXwv-3lL4xw3Cw1c_a5TJygwgDijNm8D_1SD3T4b-w87tp74l90en4yN5dHj87RV5ADoTXXrpLtleXC7ta4CAi-qNt_R_WGZclg |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1fi9QwEA_nCYcv4n-rp0YR8aWybdOmwSc5b9lT91jEg8OXkOYPW1y75boL-uZ3uG_oJ3EmzZZb7oR7KJQmnS47mcwvk5lfCHmd6aoSzNlYaG1jPA8pBhQyirVRnBvBtGNYnDw9LiYn7NNpfrpD3m9qYXp-iCHghpbh52s08Na4C0auW_cOvHOe3yA3cbMPh3fKZsMWAs_86WIJ43mM55oEWiFM4xle3XZGlxDm5UTJQCe6jWS9KxrfIbcDhqQfeqXfJTu2uUf2pmGX_D45n8DwXVFXe75tan-hi-qo_dmusKiJ9qWJdAEwk2K6o48BqjOKrM7LhaV1QwPdakcxThsaak3nvWBVYzI7VY2hfR3lb9qtK4zodPTvn3OqqPYDT9Pp1yPqGWwfkJPx4beDSRwOX4h1ASAursBzgYOD9atRo9RZwUwmCgc2nDIjjBBVmTKY6FlSlVxYY4sS_qZk5JwtrGEse0h2m2VjHxOaAwgruMtHKlGs1KkCiKGFKy03gD9tEZG3Gy1IHZjJ8YCMhdysUEBh0issIq-Grm1Px3FVp_2NKmWwyE6mKcZ2MKMyIi-HZrAl3CBRjV2uoQ8sF2GZDpgwIo96zQ9fgXnRV9NEhG-NiaED8nRvtzT13PN186xEVBCRw370bL2yWLdwVXDJzkpeZRwwtYafYhLJCitkaXgqeZEkXLmUay0i8v0KOf1qTQaKqHmQ116I_V5T-JsrhIdHP2qUycoMEA4ozZvA_9UgD2Zjf_Pk-l1fkL3Zx7H8cnT8-Sm5BSoTfXLpPtldna3tMwCAq-q5N_R_C35byA |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Heart+filling+exceeds+emptying+during+late+ventricular+systole+in+patients+with+systolic+heart+failure+and+healthy+subjects+-+a+cardiac+MRI+study&rft.jtitle=Clinical+physiology+and+functional+imaging&rft.au=Carlsson%2C+Marcus&rft.au=Ugander%2C+Martin&rft.au=Kanski%2C+Mikael&rft.au=Borgquist%2C+Rasmus&rft.date=2019-05-01&rft.issn=1475-097X&rft.eissn=1475-097X&rft.volume=39&rft.issue=3&rft.spage=192&rft_id=info:doi/10.1111%2Fcpf.12555&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1475-0961&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1475-0961&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1475-0961&client=summon |