Unique features of transcription termination and initiation at closely spaced tandem human genes

• Published in: Molecular systems biology Vol. 18; no. 4; pp. e10682 - n/a
• Main Authors: Nissani, Noa, Ulitsky, Igor
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.04.2022; EMBO Press; John Wiley and Sons Inc; Springer Nature
• Subjects: Argonaute 2 protein; Argonaute proteins; Binding sites; Chemical synthesis; DNA-directed RNA polymerase; Elongation; EMBO09; Gene expression; Genes; genome organization; Genomes; Guanines; Humans; Interference; Mammals; Perturbation; Pol2 transcription; Promoter Regions, Genetic; Ribonucleic acid; RNA; RNA polymerase; RNA polymerase II; RNA Polymerase II - genetics; RNA Polymerase II - metabolism; RNA, Messenger; RNA-mediated interference; Splicing; tandem genes; Transcription elongation; Transcription initiation; Transcription termination; Transcription, Genetic; transcriptional interference; Argonaute proteins; Pol2 transcription; transcriptional interference; tandem genes; genome organization

The synthesis of RNA polymerase II (Pol2) products, which include messenger RNAs or long noncoding RNAs, culminates in transcription termination. How the transcriptional termination of a gene impacts the activity of promoters found immediately downstream of it, and which can be subject to potential...