360-OR: Hyperglucagonemia Reduces De Novo Lipogenesis and Increases Gluconeogenesis in Healthy Subjects

• Published in: Diabetes (New York, N.Y.) Vol. 71; no. Supplement_1
• Main Authors: CHEN, XI, CARLI, FABRIZIA, PEZZICA, SAMANTHA, MOCCIARO, GABRIELE, CIOCIARO, DEMETRIO, GASTALDELLI, AMALIA, DEFRONZO, RALPH A., TRIPATHY, DEVJIT
• Format: Journal Article
• Language: English
• Published: New York American Diabetes Association 01.06.2022
• Subjects: Adipose tissue; Diabetes; Gas chromatography; Glucagon; Gluconeogenesis; Glucose; Glucose metabolism; Lipid metabolism; Lipogenesis; Lipolysis; Liver; Mass spectroscopy; Metabolism; Palmitic acid; Plasma; Triglycerides

Although the effect of glucagon on glucose metabolism has been well characterized, its effect on lipid metabolism, particularly lipolysis and de novo lipogenesis, in humans in vivo has been poorly studied with controversial results. We examined the effect of short-term hyperglucagonemia on de novo l...