Modulation of Ciliary Phosphoinositide Content Regulates Trafficking and Sonic Hedgehog Signaling Output

Ciliary transport is required for ciliogenesis, signal transduction, and trafficking of receptors to the primary cilium. Mutations in inositol polyphosphate 5-phosphatase E (INPP5E) have been associated with ciliary dysfunction; however, its role in regulating ciliary phosphoinositides is unknown. H...

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Published inDevelopmental cell Vol. 34; no. 3; pp. 338 - 350
Main Authors Chávez, Marcelo, Ena, Sabrina, Van Sande, Jacqueline, de Kerchove d’Exaerde, Alban, Schurmans, Stéphane, Schiffmann, Serge N.
Format Journal Article Web Resource
LanguageEnglish
Published United States Elsevier Inc 10.08.2015
Elsevier Science
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Abstract Ciliary transport is required for ciliogenesis, signal transduction, and trafficking of receptors to the primary cilium. Mutations in inositol polyphosphate 5-phosphatase E (INPP5E) have been associated with ciliary dysfunction; however, its role in regulating ciliary phosphoinositides is unknown. Here we report that in neural stem cells, phosphatidylinositol 4-phosphate (PI4P) is found in high levels in cilia whereas phosphatidylinositol (4,5)-bisphosphate (PI(4,5)P2) is not detectable. Upon INPP5E inactivation, PI(4,5)P2 accumulates at the ciliary tip whereas PI4P is depleted. This is accompanied by recruitment of the PI(4,5)P2-interacting protein TULP3 to the ciliary membrane, along with Gpr161. This results in an increased production of cAMP and a repression of the Shh transcription gene Gli1. Our results reveal the link between ciliary regulation of phosphoinositides by INPP5E and Shh regulation via ciliary trafficking of TULP3/Gpr161 and also provide mechanistic insight into ciliary alterations found in Joubert and MORM syndromes resulting from INPP5E mutations. [Display omitted] •PI4P is the main PIP in NSC primary cilia, whereas PI(4,5)P2 is not detectable•PI(4,5)P2 accumulates in cilia upon INPP5E inactivation with PI4P depletion•TULP3 and the Shh repressor Gpr161 accumulate in cilia upon INPP5E inactivation•INPP5E inactivation results in reduced DG neurogenesis and Shh signaling in NSCs Chávez et al. identify the main phosphoinositide species in neural stem cell primary cilia and show that the PIP phosphatase INPP5E regulates their levels. Loss of INPP5E changes the dominant cilium phosphoinositide species and affects recruitment of the PIP-interacting protein TULP3 and its cargo Gpr161, with effects on Shh signaling.
AbstractList Ciliary transport is required for ciliogenesis, signal transduction, and trafficking of receptors to the primary cilium. Mutations in inositol polyphosphate 5-phosphatase E (INPP5E) have been associated with ciliary dysfunction; however, its role in regulating ciliary phosphoinositides is unknown. Here we report that in neural stem cells, phosphatidylinositol 4-phosphate (PI4P) is found in high levels in cilia whereas phosphatidylinositol (4,5)-bisphosphate (PI(4,5)P2) is not detectable. Upon INPP5E inactivation, PI(4,5)P2 accumulates at the ciliary tip whereas PI4P is depleted. This is accompanied by recruitment of the PI(4,5)P2-interacting protein TULP3 to the ciliary membrane, along with Gpr161. This results in an increased production of cAMP and a repression of the Shh transcription gene Gli1. Our results reveal the link between ciliary regulation of phosphoinositides by INPP5E and Shh regulation via ciliary trafficking of TULP3/Gpr161 and also provide mechanistic insight into ciliary alterations found in Joubert and MORM syndromes resulting from INPP5E mutations.
Ciliary transport is required for ciliogenesis, signal transduction, and trafficking of receptors to the primary cilium. Mutations in inositol polyphosphate 5-phosphatase E (INPP5E) have been associated with ciliary dysfunction; however, its role in regulating ciliary phosphoinositides is unknown. Here we report that in neural stem cells, phosphatidylinositol 4-phosphate (PI4P) is found in high levels in cilia whereas phosphatidylinositol (4,5)-bisphosphate (PI(4,5)P2) is not detectable. Upon INPP5E inactivation, PI(4,5)P2 accumulates at the ciliary tip whereas PI4P is depleted. This is accompanied by recruitment of the PI(4,5)P2-interacting protein TULP3 to the ciliary membrane, along with Gpr161. This results in an increased production of cAMP and a repression of the Shh transcription gene Gli1. Our results reveal the link between ciliary regulation of phosphoinositides by INPP5E and Shh regulation via ciliary trafficking of TULP3/Gpr161 and also provide mechanistic insight into ciliary alterations found in Joubert and MORM syndromes resulting from INPP5E mutations.
Ciliary transport is required for ciliogenesis, signal transduction, and trafficking of receptors to the primary cilium. Mutations in inositol polyphosphate 5-phosphatase E (INPP5E) have been associated with ciliary dysfunction; however, its role in regulating ciliary phosphoinositides is unknown. Here we report that in neural stem cells, phosphatidylinositol 4-phosphate (PI4P) is found in high levels in cilia whereas phosphatidylinositol (4,5)-bisphosphate (PI(4,5)P2) is not detectable. Upon INPP5E inactivation, PI(4,5)P2 accumulates at the ciliary tip whereas PI4P is depleted. This is accompanied by recruitment of the PI(4,5)P2-interacting protein TULP3 to the ciliary membrane, along with Gpr161. This results in an increased production of cAMP and a repression of the Shh transcription gene Gli1. Our results reveal the link between ciliary regulation of phosphoinositides by INPP5E and Shh regulation via ciliary trafficking of TULP3/Gpr161 and also provide mechanistic insight into ciliary alterations found in Joubert and MORM syndromes resulting from INPP5E mutations. [Display omitted] •PI4P is the main PIP in NSC primary cilia, whereas PI(4,5)P2 is not detectable•PI(4,5)P2 accumulates in cilia upon INPP5E inactivation with PI4P depletion•TULP3 and the Shh repressor Gpr161 accumulate in cilia upon INPP5E inactivation•INPP5E inactivation results in reduced DG neurogenesis and Shh signaling in NSCs Chávez et al. identify the main phosphoinositide species in neural stem cell primary cilia and show that the PIP phosphatase INPP5E regulates their levels. Loss of INPP5E changes the dominant cilium phosphoinositide species and affects recruitment of the PIP-interacting protein TULP3 and its cargo Gpr161, with effects on Shh signaling.
Author Van Sande, Jacqueline
de Kerchove d’Exaerde, Alban
Ena, Sabrina
Schiffmann, Serge N.
Chávez, Marcelo
Schurmans, Stéphane
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  surname: Chávez
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– sequence: 2
  givenname: Sabrina
  surname: Ena
  fullname: Ena, Sabrina
  organization: Laboratory of Neurophysiology, ULB Neuroscience Institute, Université Libre de Bruxelles (ULB), Brussels 1070, Belgium
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  givenname: Jacqueline
  surname: Van Sande
  fullname: Van Sande, Jacqueline
  organization: IRIBHM, Université Libre de Bruxelles, Brussels 1070, Belgium
– sequence: 4
  givenname: Alban
  surname: de Kerchove d’Exaerde
  fullname: de Kerchove d’Exaerde, Alban
  organization: Laboratory of Neurophysiology, ULB Neuroscience Institute, Université Libre de Bruxelles (ULB), Brussels 1070, Belgium
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– sequence: 6
  givenname: Serge N.
  surname: Schiffmann
  fullname: Schiffmann, Serge N.
  email: sschiffm@ulb.ac.be
  organization: Laboratory of Neurophysiology, ULB Neuroscience Institute, Université Libre de Bruxelles (ULB), Brussels 1070, Belgium
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Cites_doi 10.1126/science.1061233
10.1038/ng.423
10.1242/jcs.02912
10.1371/journal.pgen.0010053
10.1016/j.tcb.2013.01.009
10.1523/JNEUROSCI.21-18-07153.2001
10.1007/978-94-007-3012-0_7
10.1101/gad.1966210
10.1128/MCB.01089-09
10.1242/dev.070805
10.1093/hmg/ddp113
10.1038/ng.891
10.1385/MN:34:3:153
10.1016/j.neuron.2011.05.018
10.1016/S0896-6273(02)01133-9
10.1083/jcb.201101005
10.1016/j.cub.2012.01.031
10.1038/nn.3451
10.1038/ng.427
10.1126/science.1222483
10.1126/science.1139740
10.1016/S0092-8674(00)80783-7
10.1042/BJ20090428
10.1016/j.neuroscience.2004.04.061
10.1042/bj3630657
10.1038/nn983
10.1038/embor.2012.73
10.1186/1750-2187-5-1
10.1002/glia.20741
10.1038/373711a0
10.1083/jcb.201004108
10.1038/ncb2560
10.1007/978-94-007-3015-1_6
10.1128/MCB.00203-06
10.1177/002215540305100302
10.1073/pnas.0804558105
10.1002/bdra.20686
10.1038/nature04117
10.1016/j.tcb.2012.02.001
10.1152/physrev.00028.2012
10.1038/nn2059
10.1016/S0076-6879(06)19001-1
10.1016/j.cub.2009.05.025
10.1101/gad.10.6.647
10.1073/pnas.0912180106
10.1016/j.devcel.2014.01.022
10.5483/BMBRep.2010.43.2.127
10.1016/j.cell.2012.12.026
10.1083/jcb.201110049
10.1016/j.devcel.2012.01.006
10.1073/pnas.0608291103
10.1242/jcs.024927
10.1186/gb-2011-12-6-225
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References Watt, Kular, Fleming, Downes, Lucocq (bib50) 2002; 363
Higginbotham, Guo, Yokota, Umberger, Su, Li, Verma, Hirt, Ghukasyan, Caspary, Anton (bib20) 2013; 16
Lepage, Cohen, Diaz-Benjumea, Parkhurst (bib31) 1995; 373
Zhang, Mao, Janmey, Yin (bib54) 2012; 59
Tao, Gong, Luo, Zang, Guo, Wen, Luo (bib45) 2010; 5
Berbari, O’Connor, Haycraft, Yoder (bib2) 2009; 19
Doetsch, Petreanu, Caille, Garcia-Verdugo, Alvarez-Buylla (bib10) 2002; 36
Jensen, Parmar (bib24) 2006; 34
Breunig, Sarkisian, Arellano, Morozov, Ayoub, Sojitra, Wang, Flavell, Rakic, Town (bib4) 2008; 105
Franco, Gulluni, Campa, Costa, Margaria, Ciraolo, Martini, Monteyne, De Luca, Germena (bib12) 2014; 28
Liem, Ashe, He, Satir, Moran, Beier, Wicking, Anderson (bib32) 2012; 197
Haycraft, Banizs, Aydin-Son, Zhang, Michaud, Yoder (bib19) 2005; 1
Danilov, Gomes-Leal, Ahlenius, Kokaia, Carlemalm, Lindvall (bib8) 2009; 57
Doetsch, Caillé, Lim, García-Verdugo, Alvarez-Buylla (bib9) 1999; 97
Mukhopadhyay, Wen, Ratti, Loktev, Rangell, Scales, Jackson (bib36) 2013; 152
Rietze, Reynolds (bib41) 2006; 419
Balla (bib1) 2013; 93
Corbit, Aanstad, Singla, Norman, Stainier, Reiter (bib6) 2005; 437
Kwon, Lee, Choi, Ahn (bib29) 2010; 43
Czarnecki, Shah (bib7) 2012; 22
Norman, Ko, Huang, Eun, Abler, Zhang, Sun, Eggenschwiler (bib39) 2009; 18
Santagata, Boggon, Baird, Gomez, Zhao, Shan, Myszka, Shapiro (bib43) 2001; 292
Hammond, Schiavo, Irvine (bib16) 2009; 422
Murdoch, Copp (bib37) 2010; 88
Han, Spassky, Romaguera-Ros, Garcia-Verdugo, Aguilar, Schneider-Maunoury, Alvarez-Buylla (bib18) 2008; 11
Tuson, He, Anderson (bib48) 2011; 138
Kobayashi, Dynlacht (bib27) 2011; 193
Ihrie, Shah, Harwell, Levine, Guinto, Lezameta, Kriegstein, Alvarez-Buylla (bib21) 2011; 71
Lopez-Rios, Speziale, Robay, Scotti, Osterwalder, Nusspaumer, Galli, Holländer, Kmita, Zeller (bib33) 2012; 22
Kong, Horan, Sriratana, Bailey, Collyer, Nandurkar, Shisheva, Layton, Rasko, Rowe, Mitchell (bib28) 2006; 26
Mukhopadhyay, Wen, Chih, Nelson, Lane, Scales, Jackson (bib35) 2010; 24
Brooker, Harper, Terasaki, Moylan (bib5) 1979; 10
Garcia-Gonzalo, Corbit, Sirerol-Piquer, Ramaswami, Otto, Noriega, Seol, Robinson, Bennett, Josifova (bib13) 2011; 43
Dyson, Fedele, Davies, Becanovic, Mitchell (bib11) 2012; 58
Wei, Zhang, Li, Zhang, Ling, Hu (bib52) 2012; 14
Lai, Kaspar, Gage, Schaffer (bib30) 2003; 6
Tukachinsky, Lopez, Salic (bib47) 2010; 191
Ishikawa, Thompson, Yates, Marshall (bib22) 2012; 22
Jacoby, Cox, Gayral, Hampshire, Ayub, Blockmans, Pernot, Kisseleva, Compère, Schiffmann (bib23) 2009; 41
Wei, Rollins, Fabian, Hayes, Polevoy, Bazinet, Brill (bib51) 2008; 121
Bielas, Silhavy, Brancati, Kisseleva, Al-Gazali, Sztriha, Bayoumi, Zaki, Abdel-Aleem, Rosti (bib3) 2009; 41
Wen, Lai, Evangelista, Hongo, de Sauvage, Scales (bib53) 2010; 30
Hammond, Dove, Nicol, Pinxteren, Zicha, Schiavo (bib15) 2006; 119
Hammond, Fischer, Anderson, Holdich, Koteci, Balla, Irvine (bib17) 2012; 337
Tattersfield, Croon, Liu, Kells, Faull, Connor (bib46) 2004; 127
Kim, Kato, Beachy (bib25) 2009; 106
Seri, García-Verdugo, McEwen, Alvarez-Buylla (bib44) 2001; 21
Vieira, Gaus, Verkade, Fullekrug, Vaz, Simons (bib49) 2006; 103
Reiter, Blacque, Leroux (bib40) 2012; 13
Hammerschmidt, Bitgood, McMahon (bib14) 1996; 10
Niswender, Gallis, Blevins, Corson, Schwartz, Baskin (bib38) 2003; 51
Rohatgi, Milenkovic, Scott (bib42) 2007; 317
Kim, Hernandez, Balla (bib26) 2013; 23
Mukhopadhyay, Jackson (bib34) 2011; 12
26798853 - Nat Rev Mol Cell Biol. 2015 Nov;16(11):641
26305588 - Dev Cell. 2015 Aug 24;34(4):379-80
Doetsch (10.1016/j.devcel.2015.06.016_bib9) 1999; 97
Brooker (10.1016/j.devcel.2015.06.016_bib5) 1979; 10
Hammond (10.1016/j.devcel.2015.06.016_bib16) 2009; 422
Hammond (10.1016/j.devcel.2015.06.016_bib17) 2012; 337
Bielas (10.1016/j.devcel.2015.06.016_bib3) 2009; 41
Breunig (10.1016/j.devcel.2015.06.016_bib4) 2008; 105
Higginbotham (10.1016/j.devcel.2015.06.016_bib20) 2013; 16
Jacoby (10.1016/j.devcel.2015.06.016_bib23) 2009; 41
Dyson (10.1016/j.devcel.2015.06.016_bib11) 2012; 58
Kwon (10.1016/j.devcel.2015.06.016_bib29) 2010; 43
Seri (10.1016/j.devcel.2015.06.016_bib44) 2001; 21
Kong (10.1016/j.devcel.2015.06.016_bib28) 2006; 26
Tao (10.1016/j.devcel.2015.06.016_bib45) 2010; 5
Wei (10.1016/j.devcel.2015.06.016_bib52) 2012; 14
Han (10.1016/j.devcel.2015.06.016_bib18) 2008; 11
Hammerschmidt (10.1016/j.devcel.2015.06.016_bib14) 1996; 10
Santagata (10.1016/j.devcel.2015.06.016_bib43) 2001; 292
Rohatgi (10.1016/j.devcel.2015.06.016_bib42) 2007; 317
Vieira (10.1016/j.devcel.2015.06.016_bib49) 2006; 103
Ihrie (10.1016/j.devcel.2015.06.016_bib21) 2011; 71
Liem (10.1016/j.devcel.2015.06.016_bib32) 2012; 197
Haycraft (10.1016/j.devcel.2015.06.016_bib19) 2005; 1
Murdoch (10.1016/j.devcel.2015.06.016_bib37) 2010; 88
Wen (10.1016/j.devcel.2015.06.016_bib53) 2010; 30
Tattersfield (10.1016/j.devcel.2015.06.016_bib46) 2004; 127
Rietze (10.1016/j.devcel.2015.06.016_bib41) 2006; 419
Doetsch (10.1016/j.devcel.2015.06.016_bib10) 2002; 36
Jensen (10.1016/j.devcel.2015.06.016_bib24) 2006; 34
Mukhopadhyay (10.1016/j.devcel.2015.06.016_bib35) 2010; 24
Niswender (10.1016/j.devcel.2015.06.016_bib38) 2003; 51
Lopez-Rios (10.1016/j.devcel.2015.06.016_bib33) 2012; 22
Zhang (10.1016/j.devcel.2015.06.016_bib54) 2012; 59
Garcia-Gonzalo (10.1016/j.devcel.2015.06.016_bib13) 2011; 43
Czarnecki (10.1016/j.devcel.2015.06.016_bib7) 2012; 22
Lepage (10.1016/j.devcel.2015.06.016_bib31) 1995; 373
Tukachinsky (10.1016/j.devcel.2015.06.016_bib47) 2010; 191
Mukhopadhyay (10.1016/j.devcel.2015.06.016_bib36) 2013; 152
Hammond (10.1016/j.devcel.2015.06.016_bib15) 2006; 119
Wei (10.1016/j.devcel.2015.06.016_bib51) 2008; 121
Berbari (10.1016/j.devcel.2015.06.016_bib2) 2009; 19
Corbit (10.1016/j.devcel.2015.06.016_bib6) 2005; 437
Mukhopadhyay (10.1016/j.devcel.2015.06.016_bib34) 2011; 12
Kobayashi (10.1016/j.devcel.2015.06.016_bib27) 2011; 193
Norman (10.1016/j.devcel.2015.06.016_bib39) 2009; 18
Reiter (10.1016/j.devcel.2015.06.016_bib40) 2012; 13
Watt (10.1016/j.devcel.2015.06.016_bib50) 2002; 363
Ishikawa (10.1016/j.devcel.2015.06.016_bib22) 2012; 22
Kim (10.1016/j.devcel.2015.06.016_bib25) 2009; 106
Lai (10.1016/j.devcel.2015.06.016_bib30) 2003; 6
Danilov (10.1016/j.devcel.2015.06.016_bib8) 2009; 57
Kim (10.1016/j.devcel.2015.06.016_bib26) 2013; 23
Tuson (10.1016/j.devcel.2015.06.016_bib48) 2011; 138
Balla (10.1016/j.devcel.2015.06.016_bib1) 2013; 93
Franco (10.1016/j.devcel.2015.06.016_bib12) 2014; 28
References_xml – volume: 34
  start-page: 153
  year: 2006
  end-page: 161
  ident: bib24
  article-title: Strengths and limitations of the neurosphere culture system
  publication-title: Mol. Neurobiol.
  contributor:
    fullname: Parmar
– volume: 119
  start-page: 2084
  year: 2006
  end-page: 2094
  ident: bib15
  article-title: Elimination of plasma membrane phosphatidylinositol (4,5)-bisphosphate is required for exocytosis from mast cells
  publication-title: J. Cell Sci.
  contributor:
    fullname: Schiavo
– volume: 10
  start-page: 647
  year: 1996
  end-page: 658
  ident: bib14
  article-title: Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo
  publication-title: Genes Dev.
  contributor:
    fullname: McMahon
– volume: 58
  start-page: 215
  year: 2012
  end-page: 279
  ident: bib11
  article-title: Phosphoinositide phosphatases: just as important as the kinases
  publication-title: Subcell. Biochem.
  contributor:
    fullname: Mitchell
– volume: 97
  start-page: 703
  year: 1999
  end-page: 716
  ident: bib9
  article-title: Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
  publication-title: Cell
  contributor:
    fullname: Alvarez-Buylla
– volume: 10
  start-page: 1
  year: 1979
  end-page: 33
  ident: bib5
  article-title: Radioimmunoassay of cyclic AMP and cyclic GMP
  publication-title: Adv. Cyclic Nucleotide Res.
  contributor:
    fullname: Moylan
– volume: 43
  start-page: 127
  year: 2010
  end-page: 132
  ident: bib29
  article-title: PI(3,4,5)P3 regulates the interaction between Akt and B23 in the nucleus
  publication-title: BMB Rep
  contributor:
    fullname: Ahn
– volume: 422
  start-page: 23
  year: 2009
  end-page: 35
  ident: bib16
  article-title: Immunocytochemical techniques reveal multiple, distinct cellular pools of PtdIns4P and PtdIns(4,5)P(2)
  publication-title: Biochem. J.
  contributor:
    fullname: Irvine
– volume: 121
  start-page: 1076
  year: 2008
  end-page: 1084
  ident: bib51
  article-title: Depletion of plasma membrane PtdIns(4,5)P2 reveals essential roles for phosphoinositides in flagellar biogenesis
  publication-title: J. Cell Sci.
  contributor:
    fullname: Brill
– volume: 22
  start-page: 414
  year: 2012
  end-page: 419
  ident: bib22
  article-title: Proteomic analysis of mammalian primary cilia
  publication-title: Curr. Biol.
  contributor:
    fullname: Marshall
– volume: 30
  start-page: 1910
  year: 2010
  end-page: 1922
  ident: bib53
  article-title: Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation
  publication-title: Mol. Cell. Biol.
  contributor:
    fullname: Scales
– volume: 419
  start-page: 3
  year: 2006
  end-page: 23
  ident: bib41
  article-title: Neural stem cell isolation and characterization
  publication-title: Methods Enzymol.
  contributor:
    fullname: Reynolds
– volume: 59
  start-page: 177
  year: 2012
  end-page: 215
  ident: bib54
  article-title: Phosphatidylinositol 4, 5 bisphosphate and the actin cytoskeleton
  publication-title: Subcell. Biochem.
  contributor:
    fullname: Yin
– volume: 41
  start-page: 1027
  year: 2009
  end-page: 1031
  ident: bib23
  article-title: INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse
  publication-title: Nat. Genet.
  contributor:
    fullname: Schiffmann
– volume: 103
  start-page: 18556
  year: 2006
  end-page: 18561
  ident: bib49
  article-title: FAPP2, cilium formation, and compartmentalization of the apical membrane in polarized Madin-Darby canine kidney (MDCK) cells
  publication-title: Proc. Natl. Acad. Sci. USA
  contributor:
    fullname: Simons
– volume: 1
  start-page: e53
  year: 2005
  ident: bib19
  article-title: Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function
  publication-title: PLoS Genet.
  contributor:
    fullname: Yoder
– volume: 6
  start-page: 21
  year: 2003
  end-page: 27
  ident: bib30
  article-title: Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo
  publication-title: Nat. Neurosci.
  contributor:
    fullname: Schaffer
– volume: 51
  start-page: 275
  year: 2003
  end-page: 283
  ident: bib38
  article-title: Immunocytochemical detection of phosphatidylinositol 3-kinase activation by insulin and leptin
  publication-title: J. Histochem. Cytochem.
  contributor:
    fullname: Baskin
– volume: 373
  start-page: 711
  year: 1995
  end-page: 715
  ident: bib31
  article-title: Signal transduction by cAMP-dependent protein kinase A in
  publication-title: Nature
  contributor:
    fullname: Parkhurst
– volume: 36
  start-page: 1021
  year: 2002
  end-page: 1034
  ident: bib10
  article-title: EGF converts transit-amplifying neurogenic precursors in the adult brain into multipotent stem cells
  publication-title: Neuron
  contributor:
    fullname: Alvarez-Buylla
– volume: 19
  start-page: R526
  year: 2009
  end-page: R535
  ident: bib2
  article-title: The primary cilium as a complex signaling center
  publication-title: Curr. Biol.
  contributor:
    fullname: Yoder
– volume: 71
  start-page: 250
  year: 2011
  end-page: 262
  ident: bib21
  article-title: Persistent sonic hedgehog signaling in adult brain determines neural stem cell positional identity
  publication-title: Neuron
  contributor:
    fullname: Alvarez-Buylla
– volume: 138
  start-page: 4921
  year: 2011
  end-page: 4930
  ident: bib48
  article-title: Protein kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tube
  publication-title: Development
  contributor:
    fullname: Anderson
– volume: 57
  start-page: 136
  year: 2009
  end-page: 152
  ident: bib8
  article-title: Ultrastructural and antigenic properties of neural stem cells and their progeny in adult rat subventricular zone
  publication-title: Glia
  contributor:
    fullname: Lindvall
– volume: 23
  start-page: 270
  year: 2013
  end-page: 278
  ident: bib26
  article-title: Inositol lipid regulation of lipid transfer in specialized membrane domains
  publication-title: Trends Cell Biol.
  contributor:
    fullname: Balla
– volume: 193
  start-page: 435
  year: 2011
  end-page: 444
  ident: bib27
  article-title: Regulating the transition from centriole to basal body
  publication-title: J. Cell Biol.
  contributor:
    fullname: Dynlacht
– volume: 43
  start-page: 776
  year: 2011
  end-page: 784
  ident: bib13
  article-title: A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition
  publication-title: Nat. Genet.
  contributor:
    fullname: Josifova
– volume: 14
  start-page: 950
  year: 2012
  end-page: 957
  ident: bib52
  article-title: The BBSome controls IFT assembly and turnaround in cilia
  publication-title: Nat. Cell Biol.
  contributor:
    fullname: Hu
– volume: 437
  start-page: 1018
  year: 2005
  end-page: 1021
  ident: bib6
  article-title: Vertebrate Smoothened functions at the primary cilium
  publication-title: Nature
  contributor:
    fullname: Reiter
– volume: 106
  start-page: 21666
  year: 2009
  end-page: 21671
  ident: bib25
  article-title: Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus
  publication-title: Proc. Natl. Acad. Sci. USA
  contributor:
    fullname: Beachy
– volume: 5
  start-page: 1
  year: 2010
  ident: bib45
  article-title: AMPK exerts dual regulatory effects on the PI3K pathway
  publication-title: J. Mol. Signal.
  contributor:
    fullname: Luo
– volume: 11
  start-page: 277
  year: 2008
  end-page: 284
  ident: bib18
  article-title: Hedgehog signaling and primary cilia are required for the formation of adult neural stem cells
  publication-title: Nat. Neurosci.
  contributor:
    fullname: Alvarez-Buylla
– volume: 337
  start-page: 727
  year: 2012
  end-page: 730
  ident: bib17
  article-title: PI4P and PI(4,5)P2 are essential but independent lipid determinants of membrane identity
  publication-title: Science
  contributor:
    fullname: Irvine
– volume: 105
  start-page: 13127
  year: 2008
  end-page: 13132
  ident: bib4
  article-title: Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signaling
  publication-title: Proc. Natl. Acad. Sci. USA
  contributor:
    fullname: Town
– volume: 41
  start-page: 1032
  year: 2009
  end-page: 1036
  ident: bib3
  article-title: Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies
  publication-title: Nat. Genet.
  contributor:
    fullname: Rosti
– volume: 22
  start-page: 837
  year: 2012
  end-page: 848
  ident: bib33
  article-title: GLI3 constrains digit number by controlling both progenitor proliferation and BMP-dependent exit to chondrogenesis
  publication-title: Dev. Cell
  contributor:
    fullname: Zeller
– volume: 191
  start-page: 415
  year: 2010
  end-page: 428
  ident: bib47
  article-title: A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes
  publication-title: J. Cell Biol.
  contributor:
    fullname: Salic
– volume: 22
  start-page: 201
  year: 2012
  end-page: 210
  ident: bib7
  article-title: The ciliary transition zone: from morphology and molecules to medicine
  publication-title: Trends Cell Biol.
  contributor:
    fullname: Shah
– volume: 24
  start-page: 2180
  year: 2010
  end-page: 2193
  ident: bib35
  article-title: TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia
  publication-title: Genes Dev.
  contributor:
    fullname: Jackson
– volume: 12
  start-page: 225
  year: 2011
  ident: bib34
  article-title: The tubby family proteins
  publication-title: Genome Biol.
  contributor:
    fullname: Jackson
– volume: 18
  start-page: 1740
  year: 2009
  end-page: 1754
  ident: bib39
  article-title: Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling
  publication-title: Hum. Mol. Genet.
  contributor:
    fullname: Eggenschwiler
– volume: 317
  start-page: 372
  year: 2007
  end-page: 376
  ident: bib42
  article-title: Patched1 regulates hedgehog signaling at the primary cilium
  publication-title: Science
  contributor:
    fullname: Scott
– volume: 13
  start-page: 608
  year: 2012
  end-page: 618
  ident: bib40
  article-title: The base of the cilium: roles for transition fibres and the transition zone in ciliary formation, maintenance and compartmentalization
  publication-title: EMBO Rep.
  contributor:
    fullname: Leroux
– volume: 21
  start-page: 7153
  year: 2001
  end-page: 7160
  ident: bib44
  article-title: Astrocytes give rise to new neurons in the adult mammalian hippocampus
  publication-title: J. Neurosci.
  contributor:
    fullname: Alvarez-Buylla
– volume: 127
  start-page: 319
  year: 2004
  end-page: 332
  ident: bib46
  article-title: Neurogenesis in the striatum of the quinolinic acid lesion model of Huntington’s disease
  publication-title: Neuroscience
  contributor:
    fullname: Connor
– volume: 93
  start-page: 1019
  year: 2013
  end-page: 1137
  ident: bib1
  article-title: Phosphoinositides: tiny lipids with giant impact on cell regulation
  publication-title: Physiol. Rev.
  contributor:
    fullname: Balla
– volume: 292
  start-page: 2041
  year: 2001
  end-page: 2050
  ident: bib43
  article-title: G-protein signaling through tubby proteins
  publication-title: Science
  contributor:
    fullname: Shapiro
– volume: 16
  start-page: 1000
  year: 2013
  end-page: 1007
  ident: bib20
  article-title: Arl13b-regulated cilia activities are essential for polarized radial glial scaffold formation
  publication-title: Nat. Neurosci.
  contributor:
    fullname: Anton
– volume: 363
  start-page: 657
  year: 2002
  end-page: 666
  ident: bib50
  article-title: Subcellular localization of phosphatidylinositol 4,5-bisphosphate using the pleckstrin homology domain of phospholipase C delta1
  publication-title: Biochem. J.
  contributor:
    fullname: Lucocq
– volume: 26
  start-page: 6065
  year: 2006
  end-page: 6081
  ident: bib28
  article-title: Phosphatidylinositol 3-phosphate [PtdIns3P] is generated at the plasma membrane by an inositol polyphosphate 5-phosphatase: endogenous PtdIns3P can promote GLUT4 translocation to the plasma membrane
  publication-title: Mol. Cell. Biol.
  contributor:
    fullname: Mitchell
– volume: 197
  start-page: 789
  year: 2012
  end-page: 800
  ident: bib32
  article-title: The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking
  publication-title: J. Cell Biol.
  contributor:
    fullname: Anderson
– volume: 28
  start-page: 647
  year: 2014
  end-page: 658
  ident: bib12
  article-title: PI3K class II α controls spatially restricted endosomal PtdIns3P and Rab11 activation to promote primary cilium function
  publication-title: Dev. Cell
  contributor:
    fullname: Germena
– volume: 88
  start-page: 633
  year: 2010
  end-page: 652
  ident: bib37
  article-title: The relationship between sonic Hedgehog signaling, cilia, and neural tube defects
  publication-title: Birth Defects Res. A Clin. Mol. Teratol.
  contributor:
    fullname: Copp
– volume: 152
  start-page: 210
  year: 2013
  end-page: 223
  ident: bib36
  article-title: The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling
  publication-title: Cell
  contributor:
    fullname: Jackson
– volume: 292
  start-page: 2041
  year: 2001
  ident: 10.1016/j.devcel.2015.06.016_bib43
  article-title: G-protein signaling through tubby proteins
  publication-title: Science
  doi: 10.1126/science.1061233
  contributor:
    fullname: Santagata
– volume: 41
  start-page: 1032
  year: 2009
  ident: 10.1016/j.devcel.2015.06.016_bib3
  article-title: Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies
  publication-title: Nat. Genet.
  doi: 10.1038/ng.423
  contributor:
    fullname: Bielas
– volume: 119
  start-page: 2084
  year: 2006
  ident: 10.1016/j.devcel.2015.06.016_bib15
  article-title: Elimination of plasma membrane phosphatidylinositol (4,5)-bisphosphate is required for exocytosis from mast cells
  publication-title: J. Cell Sci.
  doi: 10.1242/jcs.02912
  contributor:
    fullname: Hammond
– volume: 1
  start-page: e53
  year: 2005
  ident: 10.1016/j.devcel.2015.06.016_bib19
  article-title: Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.0010053
  contributor:
    fullname: Haycraft
– volume: 23
  start-page: 270
  year: 2013
  ident: 10.1016/j.devcel.2015.06.016_bib26
  article-title: Inositol lipid regulation of lipid transfer in specialized membrane domains
  publication-title: Trends Cell Biol.
  doi: 10.1016/j.tcb.2013.01.009
  contributor:
    fullname: Kim
– volume: 21
  start-page: 7153
  year: 2001
  ident: 10.1016/j.devcel.2015.06.016_bib44
  article-title: Astrocytes give rise to new neurons in the adult mammalian hippocampus
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.21-18-07153.2001
  contributor:
    fullname: Seri
– volume: 58
  start-page: 215
  year: 2012
  ident: 10.1016/j.devcel.2015.06.016_bib11
  article-title: Phosphoinositide phosphatases: just as important as the kinases
  publication-title: Subcell. Biochem.
  doi: 10.1007/978-94-007-3012-0_7
  contributor:
    fullname: Dyson
– volume: 24
  start-page: 2180
  year: 2010
  ident: 10.1016/j.devcel.2015.06.016_bib35
  article-title: TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia
  publication-title: Genes Dev.
  doi: 10.1101/gad.1966210
  contributor:
    fullname: Mukhopadhyay
– volume: 30
  start-page: 1910
  year: 2010
  ident: 10.1016/j.devcel.2015.06.016_bib53
  article-title: Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.01089-09
  contributor:
    fullname: Wen
– volume: 138
  start-page: 4921
  year: 2011
  ident: 10.1016/j.devcel.2015.06.016_bib48
  article-title: Protein kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tube
  publication-title: Development
  doi: 10.1242/dev.070805
  contributor:
    fullname: Tuson
– volume: 18
  start-page: 1740
  year: 2009
  ident: 10.1016/j.devcel.2015.06.016_bib39
  article-title: Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/ddp113
  contributor:
    fullname: Norman
– volume: 43
  start-page: 776
  year: 2011
  ident: 10.1016/j.devcel.2015.06.016_bib13
  article-title: A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition
  publication-title: Nat. Genet.
  doi: 10.1038/ng.891
  contributor:
    fullname: Garcia-Gonzalo
– volume: 34
  start-page: 153
  year: 2006
  ident: 10.1016/j.devcel.2015.06.016_bib24
  article-title: Strengths and limitations of the neurosphere culture system
  publication-title: Mol. Neurobiol.
  doi: 10.1385/MN:34:3:153
  contributor:
    fullname: Jensen
– volume: 71
  start-page: 250
  year: 2011
  ident: 10.1016/j.devcel.2015.06.016_bib21
  article-title: Persistent sonic hedgehog signaling in adult brain determines neural stem cell positional identity
  publication-title: Neuron
  doi: 10.1016/j.neuron.2011.05.018
  contributor:
    fullname: Ihrie
– volume: 36
  start-page: 1021
  year: 2002
  ident: 10.1016/j.devcel.2015.06.016_bib10
  article-title: EGF converts transit-amplifying neurogenic precursors in the adult brain into multipotent stem cells
  publication-title: Neuron
  doi: 10.1016/S0896-6273(02)01133-9
  contributor:
    fullname: Doetsch
– volume: 193
  start-page: 435
  year: 2011
  ident: 10.1016/j.devcel.2015.06.016_bib27
  article-title: Regulating the transition from centriole to basal body
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.201101005
  contributor:
    fullname: Kobayashi
– volume: 22
  start-page: 414
  year: 2012
  ident: 10.1016/j.devcel.2015.06.016_bib22
  article-title: Proteomic analysis of mammalian primary cilia
  publication-title: Curr. Biol.
  doi: 10.1016/j.cub.2012.01.031
  contributor:
    fullname: Ishikawa
– volume: 16
  start-page: 1000
  year: 2013
  ident: 10.1016/j.devcel.2015.06.016_bib20
  article-title: Arl13b-regulated cilia activities are essential for polarized radial glial scaffold formation
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.3451
  contributor:
    fullname: Higginbotham
– volume: 41
  start-page: 1027
  year: 2009
  ident: 10.1016/j.devcel.2015.06.016_bib23
  article-title: INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse
  publication-title: Nat. Genet.
  doi: 10.1038/ng.427
  contributor:
    fullname: Jacoby
– volume: 10
  start-page: 1
  year: 1979
  ident: 10.1016/j.devcel.2015.06.016_bib5
  article-title: Radioimmunoassay of cyclic AMP and cyclic GMP
  publication-title: Adv. Cyclic Nucleotide Res.
  contributor:
    fullname: Brooker
– volume: 337
  start-page: 727
  year: 2012
  ident: 10.1016/j.devcel.2015.06.016_bib17
  article-title: PI4P and PI(4,5)P2 are essential but independent lipid determinants of membrane identity
  publication-title: Science
  doi: 10.1126/science.1222483
  contributor:
    fullname: Hammond
– volume: 317
  start-page: 372
  year: 2007
  ident: 10.1016/j.devcel.2015.06.016_bib42
  article-title: Patched1 regulates hedgehog signaling at the primary cilium
  publication-title: Science
  doi: 10.1126/science.1139740
  contributor:
    fullname: Rohatgi
– volume: 97
  start-page: 703
  year: 1999
  ident: 10.1016/j.devcel.2015.06.016_bib9
  article-title: Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)80783-7
  contributor:
    fullname: Doetsch
– volume: 422
  start-page: 23
  year: 2009
  ident: 10.1016/j.devcel.2015.06.016_bib16
  article-title: Immunocytochemical techniques reveal multiple, distinct cellular pools of PtdIns4P and PtdIns(4,5)P(2)
  publication-title: Biochem. J.
  doi: 10.1042/BJ20090428
  contributor:
    fullname: Hammond
– volume: 127
  start-page: 319
  year: 2004
  ident: 10.1016/j.devcel.2015.06.016_bib46
  article-title: Neurogenesis in the striatum of the quinolinic acid lesion model of Huntington’s disease
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2004.04.061
  contributor:
    fullname: Tattersfield
– volume: 363
  start-page: 657
  year: 2002
  ident: 10.1016/j.devcel.2015.06.016_bib50
  article-title: Subcellular localization of phosphatidylinositol 4,5-bisphosphate using the pleckstrin homology domain of phospholipase C delta1
  publication-title: Biochem. J.
  doi: 10.1042/bj3630657
  contributor:
    fullname: Watt
– volume: 6
  start-page: 21
  year: 2003
  ident: 10.1016/j.devcel.2015.06.016_bib30
  article-title: Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn983
  contributor:
    fullname: Lai
– volume: 13
  start-page: 608
  year: 2012
  ident: 10.1016/j.devcel.2015.06.016_bib40
  article-title: The base of the cilium: roles for transition fibres and the transition zone in ciliary formation, maintenance and compartmentalization
  publication-title: EMBO Rep.
  doi: 10.1038/embor.2012.73
  contributor:
    fullname: Reiter
– volume: 5
  start-page: 1
  year: 2010
  ident: 10.1016/j.devcel.2015.06.016_bib45
  article-title: AMPK exerts dual regulatory effects on the PI3K pathway
  publication-title: J. Mol. Signal.
  doi: 10.1186/1750-2187-5-1
  contributor:
    fullname: Tao
– volume: 57
  start-page: 136
  year: 2009
  ident: 10.1016/j.devcel.2015.06.016_bib8
  article-title: Ultrastructural and antigenic properties of neural stem cells and their progeny in adult rat subventricular zone
  publication-title: Glia
  doi: 10.1002/glia.20741
  contributor:
    fullname: Danilov
– volume: 373
  start-page: 711
  year: 1995
  ident: 10.1016/j.devcel.2015.06.016_bib31
  article-title: Signal transduction by cAMP-dependent protein kinase A in Drosophila limb patterning
  publication-title: Nature
  doi: 10.1038/373711a0
  contributor:
    fullname: Lepage
– volume: 191
  start-page: 415
  year: 2010
  ident: 10.1016/j.devcel.2015.06.016_bib47
  article-title: A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.201004108
  contributor:
    fullname: Tukachinsky
– volume: 14
  start-page: 950
  year: 2012
  ident: 10.1016/j.devcel.2015.06.016_bib52
  article-title: The BBSome controls IFT assembly and turnaround in cilia
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb2560
  contributor:
    fullname: Wei
– volume: 59
  start-page: 177
  year: 2012
  ident: 10.1016/j.devcel.2015.06.016_bib54
  article-title: Phosphatidylinositol 4, 5 bisphosphate and the actin cytoskeleton
  publication-title: Subcell. Biochem.
  doi: 10.1007/978-94-007-3015-1_6
  contributor:
    fullname: Zhang
– volume: 26
  start-page: 6065
  year: 2006
  ident: 10.1016/j.devcel.2015.06.016_bib28
  article-title: Phosphatidylinositol 3-phosphate [PtdIns3P] is generated at the plasma membrane by an inositol polyphosphate 5-phosphatase: endogenous PtdIns3P can promote GLUT4 translocation to the plasma membrane
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.00203-06
  contributor:
    fullname: Kong
– volume: 51
  start-page: 275
  year: 2003
  ident: 10.1016/j.devcel.2015.06.016_bib38
  article-title: Immunocytochemical detection of phosphatidylinositol 3-kinase activation by insulin and leptin
  publication-title: J. Histochem. Cytochem.
  doi: 10.1177/002215540305100302
  contributor:
    fullname: Niswender
– volume: 105
  start-page: 13127
  year: 2008
  ident: 10.1016/j.devcel.2015.06.016_bib4
  article-title: Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signaling
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0804558105
  contributor:
    fullname: Breunig
– volume: 88
  start-page: 633
  year: 2010
  ident: 10.1016/j.devcel.2015.06.016_bib37
  article-title: The relationship between sonic Hedgehog signaling, cilia, and neural tube defects
  publication-title: Birth Defects Res. A Clin. Mol. Teratol.
  doi: 10.1002/bdra.20686
  contributor:
    fullname: Murdoch
– volume: 437
  start-page: 1018
  year: 2005
  ident: 10.1016/j.devcel.2015.06.016_bib6
  article-title: Vertebrate Smoothened functions at the primary cilium
  publication-title: Nature
  doi: 10.1038/nature04117
  contributor:
    fullname: Corbit
– volume: 22
  start-page: 201
  year: 2012
  ident: 10.1016/j.devcel.2015.06.016_bib7
  article-title: The ciliary transition zone: from morphology and molecules to medicine
  publication-title: Trends Cell Biol.
  doi: 10.1016/j.tcb.2012.02.001
  contributor:
    fullname: Czarnecki
– volume: 93
  start-page: 1019
  year: 2013
  ident: 10.1016/j.devcel.2015.06.016_bib1
  article-title: Phosphoinositides: tiny lipids with giant impact on cell regulation
  publication-title: Physiol. Rev.
  doi: 10.1152/physrev.00028.2012
  contributor:
    fullname: Balla
– volume: 11
  start-page: 277
  year: 2008
  ident: 10.1016/j.devcel.2015.06.016_bib18
  article-title: Hedgehog signaling and primary cilia are required for the formation of adult neural stem cells
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn2059
  contributor:
    fullname: Han
– volume: 419
  start-page: 3
  year: 2006
  ident: 10.1016/j.devcel.2015.06.016_bib41
  article-title: Neural stem cell isolation and characterization
  publication-title: Methods Enzymol.
  doi: 10.1016/S0076-6879(06)19001-1
  contributor:
    fullname: Rietze
– volume: 19
  start-page: R526
  year: 2009
  ident: 10.1016/j.devcel.2015.06.016_bib2
  article-title: The primary cilium as a complex signaling center
  publication-title: Curr. Biol.
  doi: 10.1016/j.cub.2009.05.025
  contributor:
    fullname: Berbari
– volume: 10
  start-page: 647
  year: 1996
  ident: 10.1016/j.devcel.2015.06.016_bib14
  article-title: Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo
  publication-title: Genes Dev.
  doi: 10.1101/gad.10.6.647
  contributor:
    fullname: Hammerschmidt
– volume: 106
  start-page: 21666
  year: 2009
  ident: 10.1016/j.devcel.2015.06.016_bib25
  article-title: Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0912180106
  contributor:
    fullname: Kim
– volume: 28
  start-page: 647
  year: 2014
  ident: 10.1016/j.devcel.2015.06.016_bib12
  article-title: PI3K class II α controls spatially restricted endosomal PtdIns3P and Rab11 activation to promote primary cilium function
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2014.01.022
  contributor:
    fullname: Franco
– volume: 43
  start-page: 127
  year: 2010
  ident: 10.1016/j.devcel.2015.06.016_bib29
  article-title: PI(3,4,5)P3 regulates the interaction between Akt and B23 in the nucleus
  publication-title: BMB Rep
  doi: 10.5483/BMBRep.2010.43.2.127
  contributor:
    fullname: Kwon
– volume: 152
  start-page: 210
  year: 2013
  ident: 10.1016/j.devcel.2015.06.016_bib36
  article-title: The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling
  publication-title: Cell
  doi: 10.1016/j.cell.2012.12.026
  contributor:
    fullname: Mukhopadhyay
– volume: 197
  start-page: 789
  year: 2012
  ident: 10.1016/j.devcel.2015.06.016_bib32
  article-title: The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.201110049
  contributor:
    fullname: Liem
– volume: 22
  start-page: 837
  year: 2012
  ident: 10.1016/j.devcel.2015.06.016_bib33
  article-title: GLI3 constrains digit number by controlling both progenitor proliferation and BMP-dependent exit to chondrogenesis
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2012.01.006
  contributor:
    fullname: Lopez-Rios
– volume: 103
  start-page: 18556
  year: 2006
  ident: 10.1016/j.devcel.2015.06.016_bib49
  article-title: FAPP2, cilium formation, and compartmentalization of the apical membrane in polarized Madin-Darby canine kidney (MDCK) cells
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0608291103
  contributor:
    fullname: Vieira
– volume: 121
  start-page: 1076
  year: 2008
  ident: 10.1016/j.devcel.2015.06.016_bib51
  article-title: Depletion of plasma membrane PtdIns(4,5)P2 reveals essential roles for phosphoinositides in flagellar biogenesis
  publication-title: J. Cell Sci.
  doi: 10.1242/jcs.024927
  contributor:
    fullname: Wei
– volume: 12
  start-page: 225
  year: 2011
  ident: 10.1016/j.devcel.2015.06.016_bib34
  article-title: The tubby family proteins
  publication-title: Genome Biol.
  doi: 10.1186/gb-2011-12-6-225
  contributor:
    fullname: Mukhopadhyay
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Snippet Ciliary transport is required for ciliogenesis, signal transduction, and trafficking of receptors to the primary cilium. Mutations in inositol polyphosphate...
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SubjectTerms Abnormalities, Multiple - genetics
Animals
Biochemistry, biophysics & molecular biology
Biochimie, biophysique & biologie moléculaire
Cell Movement - genetics
Cells, Cultured
Cerebellar Diseases - genetics
Cerebellum - abnormalities
Cilia - metabolism
Cyclic AMP - biosynthesis
Embryo, Mammalian - metabolism
Eye Abnormalities - genetics
Eye Diseases - genetics
Hedgehog Proteins - metabolism
Hippocampus - embryology
Intellectual Disability - genetics
Kidney Diseases, Cystic - genetics
Kruppel-Like Transcription Factors - biosynthesis
Kruppel-Like Transcription Factors - genetics
Life sciences
Mice
Mice, Inbred C57BL
Mice, Transgenic
Neural Stem Cells - metabolism
Obesity - genetics
Penile Diseases - genetics
phosphatase
Phosphatidylinositol 4,5-Diphosphate - metabolism
Phosphatidylinositol Phosphates - metabolism
phosphoinositide
Phosphoric Monoester Hydrolases - genetics
primary cilium
Protein Transport - genetics
Proteins - metabolism
Receptors, G-Protein-Coupled - metabolism
Retina - abnormalities
Sciences du vivant
Signal Transduction
Zinc Finger Protein GLI1
Title Modulation of Ciliary Phosphoinositide Content Regulates Trafficking and Sonic Hedgehog Signaling Output
URI https://dx.doi.org/10.1016/j.devcel.2015.06.016
https://www.ncbi.nlm.nih.gov/pubmed/26190144
https://search.proquest.com/docview/1704353237
http://orbi.ulg.ac.be/handle/2268/184375
Volume 34
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