KDM1A Identified as a Potential Oncogenic Driver and Prognostic Biomarker via Multi-Omics Analysis

• Published in: The Canadian journal of infectious diseases & medical microbiology Vol. 2021; pp. 1 - 18
• Main Authors: Li, Lingyue, Wang, Yiyu, Mou, Yuan, Wu, Hao, Qin, Ye
• Format: Journal Article
• Language: English
• Published: Egypt Hindawi 09.12.2021; John Wiley & Sons, Inc; Wiley
• Subjects: Biomarkers; Cancer; Carcinogenesis; Carcinogens; Cell cycle; Correlation analysis; Demethylation; Development and progression; DNA methylation; Epigenetics; Fibroblasts; Gene expression; Genetic analysis; Genetic diversity; Genomes; Genotypes; Health aspects; Helper cells; Histones; Identification and classification; Immune system; Immunogenicity; Infectious diseases; Infiltration; Leukemia; Lymphocytes T; Lysine; Medical prognosis; Metastases; Mutation; Oncogenes; Pathogenesis; Phosphorylation; Physiological aspects; Prognosis; Proteins; Proteomics; Risk factors; RNA transport; Software; Suppressor cells; Survival analysis; Tumors; China

Background. Lysine-specific demethylase 1A (KDM1A) is a histone demethylation enzyme and a crucial epigenetic factor for multiple pathological pathways that mediate carcinogenesis and immunogenicity. Although increasing evidence supposes the association between KDM1A and cancers, no systematic multi...