COMPASS identifies T-cell subsets correlated with clinical outcomes

• Published in: Nature biotechnology Vol. 33; no. 6; pp. 610 - 616
• Main Authors: Lin, Lin, Finak, Greg, Ushey, Kevin, Seshadri, Chetan, Hawn, Thomas R, Frahm, Nicole, Scriba, Thomas J, Mahomed, Hassan, Hanekom, Willem, Bart, Pierre-Alexandre, Pantaleo, Giuseppe, Tomaras, Georgia D, Rerks-Ngarm, Supachai, Kaewkungwal, Jaranit, Nitayaphan, Sorachai, Pitisuttithum, Punnee, Michael, Nelson L, Kim, Jerome H, Robb, Merlin L, O'Connell, Robert J, Karasavvas, Nicos, Gilbert, Peter, C De Rosa, Stephen, McElrath, M Juliana, Gottardo, Raphael
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.06.2015; Nature Publishing Group
• Subjects: 13/21; 631/114/2415; 631/250; 82/80; Agriculture; AIDS Vaccines - administration & dosage; AIDS Vaccines - immunology; analysis; Bioinformatics; Biomedical Engineering/Biotechnology; Biomedicine; Biotechnology; Case-Control Studies; Clinical outcomes; Cytokines - biosynthesis; Cytokines - blood; Cytokines - immunology; Female; Flow Cytometry; Gene Products, env - immunology; Gene Products, env - therapeutic use; Health aspects; Healthy Volunteers; Heterogeneity; HIV; HIV Infections - blood; HIV Infections - drug therapy; HIV Infections - immunology; HIV Infections - virology; HIV-1 - immunology; HIV-1 - pathogenicity; Human immunodeficiency virus; Humans; Immunity, Cellular; Immunoglobulin A - blood; Life Sciences; Male; Methods; Single-Cell Analysis; T cells; T-Lymphocyte Subsets - immunology; Treatment Outcome; Vaccines

Computational analysis of antigen-specific T cell subsets highlights individual-level variation in immune response quality. Advances in flow cytometry and other single-cell technologies have enabled high-dimensional, high-throughput measurements of individual cells as well as the interrogation of ce...