Curcumae Ameliorates Diethylnitrosamine-Induced Hepatocellular Carcinoma via Alteration of Oxidative Stress, Inflammation and Gut Microbiota

• Published in: Journal of inflammation research Vol. 14; pp. 5551 - 5566
• Main Authors: Zhang, Yunyan, Li, Xuelian, Li, Xinghua
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2021; Taylor & Francis Ltd; Dove; Dove Medical Press
• Subjects: Animal experimentation; antioxidant; Antioxidants; Bioengineering; Carcinogens; Chemotherapy; curcumae; Cyclooxygenase-2; Cytochrome; Cytokines; Diethylnitrosamine; Disease; Enzymes; Fatty liver; gut microbiota; hepatic cellular carcinoma; Hepatocellular carcinoma; Hepatoma; High fat diet; IL-1β; Inflammation; Interleukin 10; Interleukin 2; Interleukin 6; Interleukin 7; Interleukins; Intestinal microflora; Liver cancer; Liver cirrhosis; Liver diseases; Manufacturers; Medical prognosis; Microbiota; Microbiota (Symbiotic organisms); Mortality; NF-κB protein; Original Research; Oxidative stress; Phosphatase; Prostaglandin E2; Prostaglandins E; Risk factors; Tumor necrosis factor-α; Variance analysis; China; St Louis Missouri; United States > US; curcumae; antioxidant; inflammation; gut microbiota; hepatic cellular carcinoma

Nonalcoholic fatty liver disease (NAFLD) increased the risk factor of hepatocellular carcinoma (HCC). NAFLD induces the hepatic-related cancer deaths mostly in middle-aged men. NAFLD enhanced the inflammatory reaction and oxidative stress in the hepatic tissue. Curcumae exhibited the anti-inflammato...