Cell Cycle Control by a Minimal Cdk Network

• Published in: PLoS computational biology Vol. 11; no. 2; p. e1004056
• Main Authors: Gérard, Claude, Tyson, John J., Coudreuse, Damien, Novák, Béla
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.02.2015; PLOS; Public Library of Science (PLoS)
• Subjects: Cell cycle; Cell Cycle Checkpoints - physiology; Computational Biology; Cyclin-dependent kinases; Cyclin-Dependent Kinases - metabolism; Cyclin-Dependent Kinases - physiology; DNA sequencing; Identification and classification; Kinases; Life Sciences; Methods; Models, Biological; Phosphorylation - physiology; Physiological aspects; Protein kinases; Schizosaccharomyces - metabolism; Schizosaccharomyces - physiology; Yeast

In present-day eukaryotes, the cell division cycle is controlled by a complex network of interacting proteins, including members of the cyclin and cyclin-dependent protein kinase (Cdk) families, and the Anaphase Promoting Complex (APC). Successful progression through the cell cycle depends on precis...