SARS-CoV-2 nucleocapsid protein inhibits the PKR-mediated integrated stress response through RNA-binding domain N2b

• Published in: PLoS pathogens Vol. 19; no. 8; p. e1011582
• Main Authors: Aloise, Chiara, Schipper, Jelle G., van Vliet, Arno, Oymans, Judith, Donselaar, Tim, Hurdiss, Daniel L., de Groot, Raoul J., van Kuppeveld, Frank J. M.
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 22.08.2023; Public Library of Science (PLoS)
• Subjects: Analysis; Antiviral drugs; Binding; Biological response modifiers; Biology and life sciences; Coronaviruses; COVID-19; Double-stranded RNA; Genomes; Innate immunity; Interferon; Kinases; Medicine and health sciences; Microscopy; Middle East respiratory syndrome; Mode of action; N protein; Nucleocapsids; Packaging; Plasmids; Post-translation; Proteins; Research and Analysis Methods; Respiratory diseases; Sensors; Sequestering; Severe acute respiratory syndrome coronavirus 2; Stress response; Viral diseases; Viral infections; Viruses; β-Interferon; Netherlands

The nucleocapsid protein N of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enwraps and condenses the viral genome for packaging but is also an antagonist of the innate antiviral defense. It suppresses the integrated stress response (ISR), purportedly by interacting with stress granul...