Molecular phenotyping of a UK population: defining the human serum metabolome

• Published in: Metabolomics Vol. 11; no. 1; pp. 9 - 26
• Main Authors: Dunn, Warwick B., Lin, Wanchang, Broadhurst, David, Begley, Paul, Brown, Marie, Zelena, Eva, Vaughan, Andrew A., Halsall, Antony, Harding, Nadine, Knowles, Joshua D., Francis-McIntyre, Sue, Tseng, Andy, Ellis, David I., O’Hagan, Steve, Aarons, Gill, Benjamin, Boben, Chew-Graham, Stephen, Moseley, Carly, Potter, Paula, Winder, Catherine L., Potts, Catherine, Thornton, Paula, McWhirter, Catriona, Zubair, Mohammed, Pan, Martin, Burns, Alistair, Cruickshank, J. Kennedy, Jayson, Gordon C., Purandare, Nitin, Wu, Frederick C. W., Finn, Joe D., Haselden, John N., Nicholls, Andrew W., Wilson, Ian D., Goodacre, Royston, Kell, Douglas B.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.02.2015; Springer Nature B.V
• Subjects: Biochemistry; Biomedical and Life Sciences; Biomedicine; Cell Biology; Developmental Biology; Life Sciences; Molecular Medicine; Original; Original Article; Human serum; UK population; Metabolic phenotyping; Clinical biochemistry; Mass spectrometry

Phenotyping of 1,200 ‘healthy’ adults from the UK has been performed through the investigation of diverse classes of hydrophilic and lipophilic metabolites present in serum by applying a series of chromatography–mass spectrometry platforms. These data were made robust to instrumental drift by numeri...