Persistent changes in neuronal structure and synaptic plasticity caused by proton irradiation

• Published in: Brain Structure and Function Vol. 220; no. 2; pp. 1161 - 1171
• Main Authors: Parihar, Vipan K., Pasha, Junaid, Tran, Katherine K., Craver, Brianna M., Acharya, Munjal M., Limoli, Charles L.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.03.2015; Springer Nature B.V
• Subjects: Animals; Biomarkers - metabolism; Biomedical and Life Sciences; Biomedicine; Brain research; Cell Biology; Cognition & reasoning; Dendrites - pathology; Dendrites - radiation effects; Disks Large Homolog 4 Protein; Dose-Response Relationship, Radiation; Guanylate Kinases - metabolism; Hippocampus - metabolism; Hippocampus - pathology; Hippocampus - physiopathology; Hippocampus - radiation effects; Male; Membrane Proteins - metabolism; Mice, Transgenic; Neurology; Neuronal Plasticity - radiation effects; Neurons - metabolism; Neurons - pathology; Neurons - radiation effects; Neurosciences; Original Article; Protons; Radiation therapy; Synapses - metabolism; Synapses - pathology; Synapses - radiation effects; Synaptophysin - metabolism; Time Factors; Dendritic spines; Synaptophysin; Radiation-induced cognitive dysfunction; PSD-95; Dendritic complexity

Cranial radiotherapy is used routinely to control the growth of primary and secondary brain tumors, but often results in serious and debilitating cognitive dysfunction. In part due to the beneficial dose depth distributions that may spare normal tissue damage, the use of protons to treat CNS and oth...