Soluble HLA-associated peptide from PSF1 has a cancer vaccine potency

• Published in: Scientific reports Vol. 7; no. 1; pp. 11137 - 10
• Main Authors: Yoshida, Mari, Ishioka, Yukichi, Ozawa, Takamasa, Okuyama, Hirohisa, Iguchi, Motofumi, Ota, Takeshi, Ito, Takaomi, Nagira, Morio, Morita, Atsushi, Tanaka, Hidekazu, Naito, Hisamichi, Kidoya, Hiroyasu, Takakura, Nobuyuki
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 11.09.2017; Nature Publishing Group
• Subjects: 13; 13/109; 631/67/580/1884/2323; 631/67/71; 82; 82/58; Cancer; Cancer vaccines; Cytotoxicity; Deoxyribonucleic acid; DNA; DNA biosynthesis; Epitopes; Evolutionary conservation; Histocompatibility antigen HLA; Humanities and Social Sciences; Immunogenicity; Immunotherapy; Interferon; Lymphocytes; Lymphocytes T; Mass spectrometry; Mass spectroscopy; multidisciplinary; Peptides; Progenitor cells; Replication; Science; Science (multidisciplinary); Stem cells; Tumors; Vaccination; Vaccines

Partner of sld five 1 (PSF1) is an evolutionary conserved DNA replication factor involved in DNA replication in lower species, which is strongly expressed in normal stem cell populations and progenitor cell populations. Recently, we have investigated PSF1 functions in cancer cells and found that PSF...